Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Andrew N, Holding"'
Autor:
Dominik Beck, Honghui Cao, Feng Tian, Yizhou Huang, Miao Jiang, Han Zhao, Xiaolu Tai, Wenqian Xu, Hansen J. Kosasih, David J. Kealy, Weiye Zhao, Samuel J. Taylor, Timothy A. Couttas, Gaoxian Song, Diego Chacon-Fajardo, Yashna Walia, Meng Wang, Adam A. Dowle, Andrew N. Holding, Katherine S. Bridge, Chao Zhang, Jin Wang, Jian-Qing Mi, Richard B. Lock, Charles E. de Bock, Duohui Jing
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The epigenetic landscape plays a critical role in cancer progression, yet its therapeutic potential remains underexplored. Glucocorticoids are essential components of treatments for lymphoid cancers, but resistance, driven in part by epigene
Externí odkaz:
https://doaj.org/article/5435731f29bf4866b65f5821ed78136d
Autor:
Alina L. Capatina, Jodie R. Malcolm, Jack Stenning, Rachael L. Moore, Katherine S. Bridge, William J. Brackenbury, Andrew N. Holding
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The events that control breast cancer progression and metastasis are complex and intertwined. Hypoxia plays a key role both in oncogenic transformation and in fueling the metastatic potential of breast cancer cells. Here we review the impact of hypox
Externí odkaz:
https://doaj.org/article/f6a8d132a2184bfd98fff60b790f10b2
Autor:
Ronja S. Adam, Sanne M. van Neerven, Cayetano Pleguezuelos-Manzano, Salvatore Simmini, Nicolas Léveillé, Nina E. de Groot, Andrew N. Holding, Florian Markowetz, Louis Vermeulen
Publikováno v:
Cancer Cell International, Vol 20, Iss 1, Pp 1-15 (2020)
Abstract Background Cancer results from the accumulation of mutations leading to the acquisition of cancer promoting characteristics such as increased proliferation and resistance to cell death. In colorectal cancer, an early mutation leading to such
Externí odkaz:
https://doaj.org/article/eadd93dc5c0b4df5ab1fbd8979ed785d
Autor:
Andrew N. Holding, Federico M. Giorgi, Amanda Donnelly, Amy E. Cullen, Sankari Nagarajan, Luke A. Selth, Florian Markowetz
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-16 (2019)
Abstract Background VirtUaL ChIP-seq Analysis through Networks (VULCAN) infers regulatory interactions of transcription factors by overlaying networks generated from publicly available tumor expression data onto ChIP-seq data. We apply our method to
Externí odkaz:
https://doaj.org/article/92648a09a5424a499bfc1263eb9e7330
Autor:
Evangelia K. Papachristou, Kamal Kishore, Andrew N. Holding, Kate Harvey, Theodoros I. Roumeliotis, Chandra Sekhar Reddy Chilamakuri, Soleilmane Omarjee, Kee Ming Chia, Alex Swarbrick, Elgene Lim, Florian Markowetz, Matthew Eldridge, Rasmus Siersbaek, Clive S. D’Santos, Jason S. Carroll
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Chromatin-associated protein complexes play a critical role in the regulation of gene expression in health and disease. Here, the authors describe a sensitive mass spectrometry-based method to monitor the dynamic interactions of endogenous chromatin-
Externí odkaz:
https://doaj.org/article/6d77c38577f14fe9922378d351669816
Publikováno v:
The FEBS Journal. 290:2022-2028
Metrics play a vital part in the valuation and funding of research for scientists worldwide. We review the challenges that metrics pose in providing a fair and equitable system for research funding. We highlight the attempts with declarations, includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da58386e87ea2e1a18c6fd2c4ffbcc5
https://doi.org/10.1111/febs.16674
https://doi.org/10.1111/febs.16674
Publikováno v:
eLife, Vol 7 (2018)
Estrogen Receptor-alpha (ER) drives 75% of breast cancers. Stimulation of the ER by estra-2-diol forms a transcriptionally-active chromatin-bound complex. Previous studies reported that ER binding follows a cyclical pattern. However, most studies hav
Externí odkaz:
https://doaj.org/article/6d5804efb9b147b88335309e8710833c
Autor:
Andrew N. Holding, Federico M. Giorgi, Amanda Donnelly, Amy E. Cullen, Sankari Nagarajan, Luke A. Selth, Florian Markowetz
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-2 (2019)
Following publication of the original article [1], the authors reported that Figs. 4 and 5 had mistakenly been transposed. Please find the correct Figs. 4 and 5 below. The original article [1] has been corrected.
Externí odkaz:
https://doaj.org/article/5e3c41b12a864729b8883fc2a502ceb2
Publikováno v:
Bioscience Reports
Background: Cell-surface proteins have been widely used as diagnostic and prognostic markers in cancer research and as targets for the development of anticancer agents. So far, very few attempts have been made to characterize the surfaceome of patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36ae80f3f16c4bcddcf7ae9c9ad0456
https://doi.org/10.1042/bsr20212218
https://doi.org/10.1042/bsr20212218
Autor:
Andrew N Holding
Publikováno v:
The FEBS Journal. 286:3975-3979
The pressures of a scientific career can end up incentivising an all-or-nothing approach to cross the finish line first. While competition can be healthy and drives innovation, the current system fails to encourage scientists to work reproducibility.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a624fa2a745073f671b32a93b74b1e2
https://doi.org/10.1111/febs.14965
https://doi.org/10.1111/febs.14965