Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Andrew N, Billin"'
Autor:
Islam R. Younis, Brian J. Kirby, Andrew N. Billin, Deqing Xiao, Qinghua Song, Timothy R. Watkins, Ahmed A. Othman
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 3, Pp 536-547 (2023)
Abstract Cilofexor is a nonsteroidal farnesoid X receptor (FXR) agonist being evaluated for treatment of nonalcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC). This work characterized the pharmacokinetics, pharmacodynamic, safe
Externí odkaz:
https://doaj.org/article/69d9d611a3b5404a88365bc742848b86
Autor:
Mohamad Dandan, Julia Han, Sabrina Mann, Rachael Kim, Kelvin Li, Hussein Mohammed, Jen-Chieh Chuang, Kaiyi Zhu, Andrew N. Billin, Ryan S. Huss, Chuhan Chung, Robert P. Myers, Marc Hellerstein
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 3, Pp 100339- (2023)
Treatment with acetyl-CoA carboxylase inhibitors (ACCi) in nonalcoholic steatohepatitis (NASH) may increase plasma triglycerides (TGs), with variable changes in apoB concentrations. ACC is rate limiting in de novo lipogenesis and regulates fatty acid
Externí odkaz:
https://doaj.org/article/1b47be019904410e833c7ff617ad7ca5
HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury
Autor:
Andrew N. Billin, Samuel E. Honeycutt, Alan V. McDougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S. Geske, Frank Fang, Bert Yao, Richard V. Clark, John Lepore, Alex Cobitz, Ram Miller, Kazunori Nosaka, Aaron C. Hinken, Alan J. Russell
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Background In muscular dystrophy and old age, skeletal muscle repair is compromised leading to fibrosis and fatty tissue accumulation. Therefore, therapies that protect skeletal muscle or enhance repair would be valuable medical treatments.
Externí odkaz:
https://doaj.org/article/e1f73e6f4eda4a62a3d79d3777de791e
Autor:
James P. White, Andrew N. Billin, Milton E. Campbell, Alan J. Russell, Kim M. Huffman, William E. Kraus
Publikováno v:
Stem Cell Reports, Vol 11, Iss 2, Pp 425-439 (2018)
Summary: Skeletal muscle stem cell (MuSC) function declines with age and contributes to impaired muscle regeneration in older individuals. Acting through AMPK/p27Kip1, we have identified a pathway regulating the balance between autophagy, apoptosis,
Externí odkaz:
https://doaj.org/article/9a322b4fb19d44bcb38502899b70e176
Autor:
Islam R. Younis, Chia‐Hsiang Hsueh, Cara Nelson, Andrew N. Billin, Mun Sang Yue, Deqing Xiao, Timothy R. Watkins, Ahmed A. Othman
Publikováno v:
The Journal of Clinical Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00dae8388bf225684316d45854d4615a
https://doi.org/10.1002/jcph.2260
https://doi.org/10.1002/jcph.2260
Autor:
Janani S. Iyer, Harsha Pokkalla, Charles Biddle-Snead, Oscar Carrasco-Zevallos, Mary Lin, Zahil Shanis, Quang Le, Dinkar Juyal, Maryam Pouryahya, Aryan Pedawi, Sara Hoffman, Hunter Elliott, Kenneth Leidal, Robert P. Myers, Chuhan Chung, Andrew N. Billin, Timothy R. Watkins, Murray Resnick, Katy Wack, Jon Glickman, Alastair D. Burt, Rohit Loomba, Arun J. Sanyal, Michael C. Montalto, Andrew H. Beck, Amaro Taylor-Weiner, Ilan Wapinski
Clinical trials in nonalcoholic steatohepatitis (NASH) require histologic scoring for assessment of inclusion criteria and endpoints. However, guidelines for scoring key features have led to variability in interpretation, impacting clinical trial out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf4e90e1edfaeb039c78c57d3af13b08
https://doi.org/10.1101/2023.04.20.23288534
https://doi.org/10.1101/2023.04.20.23288534
Autor:
Ekaterina, Smirnova, Mark D, Muthiah, Nicole, Narayan, Mohamad S, Siddiqui, Puneet, Puri, Velimir A, Luketic, Melissa J, Contos, Michael, Idowu, Jen-Chieh, Chuang, Andrew N, Billin, Ryan S, Huss, Robert P, Myers, Sherry, Boyett, Mulugeta, Seneshaw, Hae-Ki, Min, Faridodin, Mirshahi, Arun J, Sanyal
Publikováno v:
Hepatology. 76:1811-1824
Bile acids are hepatic metabolites and have many properties considered to be relevant to the pathophysiology of NAFLD. Circulating levels of the intestinal microbiome-modified bile acid deoxycholate are increased in cirrhosis.To further elucidate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e9c204e496a981fe3b9eb32acb3053
https://doi.org/10.1002/hep.32568
https://doi.org/10.1002/hep.32568
Autor:
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin
Publikováno v:
Hepatology (Baltimore, Md.), vol 77, iss 1
Background and aimsPruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood. Our aim was to evaluate serum IL-31 as a putative biomarker of pruritus in clinical trials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c7bfcc32e9d5782b1422ce63d86e65
https://escholarship.org/uc/item/038337xt
https://escholarship.org/uc/item/038337xt
Autor:
Eric Lawitz, G. Mani Subramanian, Zeid Kayali, Edward Gane, Mazen Noureddin, Vincent Wai-Sun Wong, Jun Xu, Stephen A. Harrison, Sergio Rojter, Eliza Harting, Mary E. Rinella, Robert Herring, C. Stephen Djedjos, Robert P. Myers, James F. Trotter, Saumya Jayakumar, Chuhan Chung, Magdy Elkhashab, Keyur Patel, Susan Greenbloom, Andrew N. Billin, Mitchell L. Shiffman, Michael S. Middleton, Bradley Freilich
Publikováno v:
Hepatology. 72:58-71
Background and aims We evaluated the safety and efficacy of cilofexor (formerly GS-9674), a small-molecule nonsteroidal agonist of farnesoid X receptor, in patients with nonalcoholic steatohepatitis (NASH). Approach and results In this double-blind,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eff69ada0d0a838eb0aba7c234c31da
https://doi.org/10.1002/hep.31205
https://doi.org/10.1002/hep.31205
Autor:
Andrew N. Billin, Samuel E. Honeycutt, Alan V. McDougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S. Geske, Frank Fang, Bert Yao, Richard V. Clark, John Lepore, Alex Cobitz, Ram Miller, Kazunori Nosaka, Aaron C. Hinken, Alan J. Russell
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-1 (2018)
Following publication of the original article [1], the authors flagged that there is a discrepancy with the Availability of data and materials statement on page 12 of the article.
Externí odkaz:
https://doaj.org/article/d03026fdb79744668aebcc8fa062fee1