Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Andrew Mitchelson"'
Autor:
Judy Hayler, Mark Talbot, Xiaoling Cockcroft, Nicholas Wills, Florence Lugrin, Keith Menear, K D Butler, Richard Price, John Ambler, Andrew Mitchelson, Peter D. Kane, Darren Mark Legrand, Karren Dunnet, Mark C. Allen, Morris Tweed
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1567-1570
The further optimisation of the novel lead compound CGH752 (Fig. 1) is described. By introducing various substituents into the 6-position of the 3,3-dimethyltetrahydroquinoline (DMTHQS) ring we have been able to favourably affect the in vitro and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53facba3ef723980cf4b0000c32556a1
https://doi.org/10.1016/s0960-894x(00)00283-3
https://doi.org/10.1016/s0960-894x(00)00283-3
Autor:
Deborah Bayley, John Ambler, Sarah Craig, Brett P. Mania, Paul L. Nicklin, Andrew Mitchelson, Judy A. Phillips
Publikováno v:
Nucleosides and Nucleotides. 16:1145-1153
Backbone, sugar and pendant-group modifications were shown to influence the anticoagulant properties of a 20-mer oligonucleotide in human plasma in vitro. The pharmacokinetics, tissue-distribution and metabolism of a chimeric oligonucleotide (CGP 698
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fb20b3aec51f9f8e5f11d279182d378
https://doi.org/10.1080/07328319708006150
https://doi.org/10.1080/07328319708006150
Publikováno v:
Molecular genetics and genomics : MGG. 267(5)
We present an analysis of a chromosomal walk in the region of the euchromatin-heterochromatin transition at the base of the X chromosome of Drosophila melanogaster. This region is difficult to analyse because of the presence of repeated sequences, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a485de311c29145b8fc389937d2bf673
https://pubmed.ncbi.nlm.nih.gov/12172804
https://pubmed.ncbi.nlm.nih.gov/12172804
Autor:
Peter D. Kane, Andrew Mitchelson, Colin Dell, Lyndon Nigel Brown, Sheila Garman, Morris Tweed, Alex Furzer, Garrick Smith, Mark Talbot, Clive Victor Walker, John Ambler, Diana Janus, Urs Baettig, Derek E. Brundish, Nicholas Wills, Xiaoling Cockcroft
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(14)
A series of monocyclic and bicyclic amino acids have been synthesised and incorporated into thrombin inhibitors based on CGH728, an analogue of the Mitsubishi compound MD805. Benzthiazolylalanine (Bta) was found to be a good non-polar substitute for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08f8ac4df35809e5380a0e81b468a5d
https://pubmed.ncbi.nlm.nih.gov/10915051
https://pubmed.ncbi.nlm.nih.gov/10915051
Publikováno v:
Genetical research. 68(3)
SummaryA 1·5 kilobasepair repeated DNA sequence is duplicated in direct orientation so as to flank thesuppressor of forkedgene in the euchromatin–heterochromatin transition region on the X chromosome ofDrosophila melanogaster. These two copies are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68fc4756621fe36daf9f6f171e4dc981
https://pubmed.ncbi.nlm.nih.gov/9062076
https://pubmed.ncbi.nlm.nih.gov/9062076
Publikováno v:
Genesdevelopment. 7(2)
The suppressor of forked [su(f)] locus of Drosophila melanogaster encodes at least one cell-autonomous vital function. Mutations at su(f) can affect the expression of unlinked genes where retroviral-like transposable elements are inserted. Changes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c68f33c8d47f35ee0bffcdb5650af9
https://pubmed.ncbi.nlm.nih.gov/8436295
https://pubmed.ncbi.nlm.nih.gov/8436295
Publikováno v:
Molecular and General Genetics MGG. 220:49-52
DNA sequences from two spontaneous mutations of Drosophila melanogaster associated with insertion of a Doc transposable element have been cloned. In white-one, the element is inserted in the white locus close to where transcription initiates. In a le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b50a187c08677545ef7405cb69cda4
https://doi.org/10.1007/bf00260854
https://doi.org/10.1007/bf00260854
Autor:
Greg Cooney, Rui Curi, Morag L.F. Simpson, Eric A. Newsholme, Andrew Mitchelson, Philip Newsholme
Publikováno v:
Biochemical and biophysical research communications. 138(2)
In general, the activities of enzymes in brown adipose tissue (BAT) are more similar to those in white adipose tissue than those in liver. Thus the activities of the glycolytic enzymes hexokinase and 6-phosphofructokinase are high but those of glucos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075d0537fbb9aa50135aa2e4645a9efd
https://pubmed.ncbi.nlm.nih.gov/3741427
https://pubmed.ncbi.nlm.nih.gov/3741427