TORPEdO: A phase III trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer

Autor: David J. Thomson, Clare Cruickshank, Helen Baines, Russell Banner, Matthew Beasley, Guy Betts, Helen Bulbeck, Frances Charlwood, Judith Christian, Matthew Clarke, Olly Donnelly, Bernadette Foran, Callum Gillies, Clare Griffin, Jarrod J. Homer, Johannes A. Langendijk, Lip Wai Lee, James Lester, Matthew Lowe, Andrew McPartlin, Elizabeth Miles, Christopher Nutting, Nachi Palaniappan, Robin Prestwich, James M. Price, Clare Roberts, Justin Roe, Ramkumar Shanmugasundaram, Rita Simões, Anna Thompson, Catharine West, Lorna Wilson, Jane Wolstenholme, Emma Hall

Publikováno v: Clinical and Translational Radiation Oncology, Vol 38, Iss , Pp 147-154 (2023)

Externí odkaz: https://doaj.org/article/efbbc2d562cf40079af68d82a83fc6b6

Changes in prostate apparent diffusion coefficient values during radiotherapy after neoadjuvant hormones

Autor: Andrew McPartlin, Lucy Kershaw, Alan McWilliam, Marcus Ben Taylor, Clare Hodgson, Marcel van Herk, Ananya Choudhury

Publikováno v: Therapeutic Advances in Urology, Vol 10 (2018)

Background: Changes in prostate cancer apparent diffusion coefficient (ADC) derived from diffusion-weighted magnetic resonance imaging (MRI) provide a noninvasive method for assessing radiotherapy response. This may be attenuated by neoadjuvant hormo

Externí odkaz: https://doaj.org/article/9e2834b970fa4f09a1bf5881e2fa9c0b

Pretreatment Lymphocyte Count Predicts Benefit From Concurrent Chemotherapy With Radiotherapy in Oropharyngeal Cancer

Autor: James M. Price, Hitesh B. Mistry, Guy Betts, Eleanor J. Cheadle, Lynne Dixon, Kate Garcez, Tim Illidge, Zsuzsanna Iyizoba-Ebozue, Lip Wai Lee, Andrew McPartlin, Robin J.D. Prestwich, Savvas Papageorgiou, Dylan J. Pritchard, Andrew Sykes, Catharine M. West, David J. Thomson

Publikováno v: Journal of Clinical Oncology. 40:2203-2212

PURPOSE There is a need to refine the selection of patients with oropharyngeal squamous cell carcinoma (OPSCC) for treatment de-escalation. We investigated whether pretreatment absolute lymphocyte count (ALC) predicted overall survival (OS) benefit f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1fcf6507099dccee6ad30bab1390c42
https://doi.org/10.1200/jco.21.01991

First-in-Human Technique Translation of Oxygen-Enhanced MRI to an MR Linac System in Patients with Head and Neck Cancer

Autor: Michael J. Dubec, David L. Buckley, Michael Berks, Abigael Clough, John Gaffney, Anubhav Datta, Damien J. McHugh, Nuria Porta, Ross A. Little, Susan Cheung, Christina Hague, Cynthia L. Eccles, Peter J. Hoskin, Robert G. Bristow, Julian C. Matthews, Marcel van Herk, Ananya Choudhury, Geoff J.M. Parker, Andrew McPartlin, James P.B. O'Connor

Publikováno v: Dubec, M J, Buckley, D L, Berks, M, Clough, A, Gaffney, J, Datta, A, McHugh, D J, Porta, N, Little, R A, Cheung, S, Hague, C, Eccles, C L, Hoskin, P J, Bristow, R G, Matthews, J C, van Herk, M, Choudhury, A, Jm Parker, G, McPartlin, A & Pb O'Connor, J 2023, ' First-in-Human Technique Translation of Oxygen-Enhanced MRI to an MR Linac System in Patients with Head and Neck Cancer ', Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, pp. 109592 . https://doi.org/10.1016/j.radonc.2023.109592

BACKGROUND AND PURPOSE: Tumour hypoxia is prognostic in head and neck cancer (HNC), associated with poor loco-regional control, poor survival and treatment resistance. The advent of hybrid MRI - radiotherapy linear accelerator or 'MR Linac' systems -

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7f73650388cb6569ade3129cfeac51
https://research.manchester.ac.uk/en/publications/606087a1-bf9b-443f-bff3-2fb57b30dd65

Open-source distributed learning validation for a larynx cancer survival model following radiotherapy

Autor: Christian Rønn Hansen, Gareth Price, Matthew Field, Nis Sarup, Ruta Zukauskaite, Jørgen Johansen, Jesper Grau Eriksen, Farhannah Aly, Andrew McPartlin, Lois Holloway, David Thwaites, Carsten Brink

Publikováno v: Hansen, C R, Price, G, Field, M, Sarup, N, Zukauskaite, R, Johansen, J, Eriksen, J G, Aly, F, McPartlin, A, Holloway, L, Thwaites, D & Brink, C 2022, ' Open-source distributed learning validation for a larynx cancer survival model following radiotherapy ', Radiotherapy and Oncology, vol. 173, pp. 319-326 . https://doi.org/10.1016/j.radonc.2022.06.009

Prediction models are useful to design personalised treatment. However, safe and effective implementation relies on external validation. Retrospective data are available in many institutions, but sharing between institutions can be challenging due to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ec606cc3cb90879394253a4214837f
https://pure.au.dk/portal/da/publications/opensource-distributed-learning-validation-for-a-larynx-cancer-survival-model-following-radiotherapy(f9e33204-4a47-43a7-b002-29cfbacdf733).html