Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Andrew Macadam"'
Autor:
Rahnuma Wahid, Laina Mercer, Chris Gast, Tirza De Leon, Xavier Sáez-Llorens, Alan Fix, Andrew Macadam, Laura Stephens, Konstantin Chumakov, Saskia L. Smits, Marta Murreddu, Jennifer L. Konopka-Anstadt, M. Steven Oberste, Cara C. Burns, Raul Andino, Novilia Sjafri Bachtiar, Erman Tritama, Ananda S. Bandyopadhyay, Gabriela Aguirre, Ricardo Rüttimann, John O. Konz
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract Novel oral poliovirus vaccine type 2 (nOPV2) is being developed to reduce the rare occurrence of disease and outbreaks associated with the genetic instability of the Sabin vaccine strains. Children aged 1 to 5 years were enrolled in two rela
Externí odkaz:
https://doaj.org/article/a5bc437be7da4f459a47f98cae18af83
Autor:
Rahnuma Wahid, Laina Mercer, Andrew Macadam, Sarah Carlyle, Laura Stephens, Javier Martin, Konstantin Chumakov, Majid Laassri, Svetlana Petrovskaya, Saskia L. Smits, Koert J. Stittelaar, Chris Gast, William C. Weldon, Jennifer L. Konopka-Anstadt, M. Steven Oberste, Pierre Van Damme, Ilse De Coster, Ricardo Rüttimann, Ananda Bandyopadhyay, John Konz
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract Sabin-strain oral polio vaccines (OPV) can, in rare instances, cause disease in recipients and susceptible contacts or evolve to become circulating vaccine-derived strains with the potential to cause outbreaks. Two novel type 2 OPV (nOPV2) c
Externí odkaz:
https://doaj.org/article/9baa83fb25b24bc98ad916e2a20f707d
Autor:
John O. Konz, Tim Schofield, Sarah Carlyle, Rahnuma Wahid, Azeem Ansari, Jeroen R.P.M. Strating, Ming Te Yeh, Hasmik Manukyan, Saskia L. Smits, Erman Tritama, Latri Rahmah, Dori Ugiyadi, Raul Andino, Majid Laassri, Konstantin Chumakov, Andrew Macadam
Publikováno v:
Vaccine: X, Vol 8, Iss , Pp 100102- (2021)
A novel, genetically-stabilized type 2 oral polio vaccine (nOPV2), developed to assist in the global polio eradication program, was recently the first-ever vaccine granted Emergency Use Listing by the WHO. Lot release tests for this vaccine included
Externí odkaz:
https://doaj.org/article/7805eacc4a144c3289cf7f764ff52931
Autor:
Hasmik Manukyan, Rahnuma Wahid, Azeem Ansari, Erman Tritama, Andrew Macadam, John Konz, Konstantin Chumakov, Majid Laassri
Publikováno v:
Vaccines, Vol 10, Iss 9, p 1394 (2022)
Emergence of mutations is an inherent property of RNA viruses with several implications for their replication, pathogenesis, and evolutionary adaptation. Oral poliovirus vaccine (OPV), developed by Albert Sabin, is composed of live attenuated poliovi
Externí odkaz:
https://doaj.org/article/0012bbec5ca942d0aea2ed8185ef5ee1
Autor:
Rahnuma Wahid, Laina D Mercer, Tirza De Leon, Rodrigo DeAntonio, Xavier Sáez-Llorens, Andrew Macadam, Konstantin Chumakov, Jeroen Strating, Björn Koel, Jennifer L Konopka-Anstadt, M Steven Oberste, Cara C Burns, Raul Andino, Erman Tritama, Ananda S Bandyopadhyay, Gabriela Aguirre, Ricardo Rüttimann, Chris Gast, John O Konz
Publikováno v:
The Lancet Microbe. 3:e912-e921
Sabin strains used in oral poliovirus vaccines (OPV) can revert to virulence and, in rare instances, cause disease or generate vaccine-derived strains leading to outbreaks in areas of low immunisation coverage. A novel OPV2 (nOPV2) was designed to st
Autor:
Javier Martin, Cara C. Burns, Jaume Jorba, Lester M. Shulman, Andrew Macadam, Dimitra Klapsa, Manasi Majumdar, James Bullows, Ann Frolov, Ryan Mate, Erika Bujaki, Christina J. Castro, Kelley Bullard, John Konz, Kaija Hawes, Jillian Gauld, Isobel M. Blake, Laina D. Mercer, Feyrouz Kurji, Arie Voorman, Ousmane M. Diop, M. Steven Oberste, John Modlin, Grace Macklin, Martin Eisenhawer, Ananda S. Bandyopadhyay, Simona Zipursky
Publikováno v:
MMWR. Morbidity and Mortality Weekly Report. 71:786-790
The emergence and international spread of neurovirulent circulating vaccine-derived polioviruses (cVDPVs) across multiple countries in Africa and Asia in recent years pose a major challenge to the goal of eradicating all forms of polioviruses. Approx
Autor:
Raul Andino, Ming Te Yeh, Matthew Smith, Sara Carlyle, Jennifer Konopka-Anstadt, John Konz, Cara Burns, Andrew Macadam
Vaccination with Sabin oral poliovirus vaccine (OPV) results in robust intestinal and humoral immunity and has been key to controlling poliomyelitis. However, as with any RNA virus, OPV can evolve rapidly . During replication, OPV strains can lose th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08dccda508bbcb2c2f165700dd03a6b8
https://doi.org/10.21203/rs.3.rs-2306887/v1
https://doi.org/10.21203/rs.3.rs-2306887/v1
Autor:
Natalie J. Kingston, Mona Shegdar, Joseph S. Snowden, Helen Fox, Elisabetta Groppelli, Andrew Macadam, David J. Rowlands, Nicola J. Stonehouse
Publikováno v:
The Journal of general virology. 103(8)
Enterovirus A71 (EVA71) infection can result in paralysis and may be fatal. In common with other picornaviruses, empty capsids are produced alongside infectious virions during the viral lifecycle. These empty capsids are antigenically indistinguishab
Autor:
Ananda S Bandyopadhyay, William C. Weldon, Ilse De Coster, Laura Stephens, Chris Gast, Javier Martin, Pierre Van Damme, Saskia L. Smits, Koert J. Stittelaar, Majid Laassri, Laina D. Mercer, John Konz, M. Steven Oberste, Andrew Macadam, Sarah Carlyle, Rahnuma Wahid, Ricardo Rüttimann, Jennifer L. Konopka-Anstadt, Konstantin Chumakov, Svetlana Petrovskaya
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
npj Vaccines
NPJ Vaccines
npj Vaccines
NPJ Vaccines
Sabin-strain oral polio vaccines (OPV) can, in rare instances, cause disease in recipients and susceptible contacts or evolve to become circulating vaccine-derived strains with the potential to cause outbreaks. Two novel type 2 OPV (nOPV2) candidates
Autor:
Kirsten Bentley, Helen Fox, David Evans, Andrew Woodman, Jonathan D. Moore, Fadi G. Alnaji, Andrew Macadam, Ashley Pearson
Publikováno v:
Viruses; Volume 14; Issue 5; Pages: 916
Recombination within RNA viruses is an important evolutionary process that can significantly influence virus fitness and has been repeatedly reported to compromise vaccine effectiveness. However, its precise mechanism is poorly understood. Here, we u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae60abcc52ce9fda935ee440f34bb3c6