Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Andrew M. Yuan"'
Publikováno v:
ICETC
The Mixed-Reality Integrated Learning Environment (MILE) developed at Florida State University is a virtual reality based, inclusive and immersive e-learning environment that promotes engaging and effective learning interactions for a diversified lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f7d59bdb45a34ac6577644173958bcb
https://doi.org/10.1145/3290511.3290554
https://doi.org/10.1145/3290511.3290554
Publikováno v:
Journal of Medicinal Chemistry. 40:506-514
The design, synthesis, and biochemical profile of meta-substituted benzofused macrocyclic lactams are described. The meta-substituted benzofused macrocyclic lactams were designed to have a degree of flexibility allowing the amide bond to occupy two c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4339b17da958f01ffe4dcdf67e23012
https://doi.org/10.1021/jm960583g
https://doi.org/10.1021/jm960583g
Autor:
L. El‐Chehabi, Mark D. Erion, Andrew M. Yuan, Gary Michael Ksander, Clive Gideon Diefenbacher, D. Cote, N. Levens
Publikováno v:
ChemInform. 25
A variety of compounds were prepared to determine whether dual angiotensin converting enzyme (ACE)/thromboxane synthase (TxS) inhibition could be obtained in the same molecule. These compounds would be used to explore the concept that a dual inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1f0a5e439ba673f6853f8db0c204e60
https://doi.org/10.1002/chin.199444174
https://doi.org/10.1002/chin.199444174
Autor:
David Louis Feldman, Randy L. Webb, Warren Lee, Ashok Hospattankar, Michael Jeune, Alan D. Neubert, Natalie A. Bilci, Natalya Alexander, Andrew M. Yuan, Therese C Mogelesky, Aida E. Navarrete, Gary Michael Ksander, Joyce C. Gibson, Eric Carlson, Haamid M. Sharif, Eli M. Wallace, Jong Wasvery, Reynalda Dejesus, Paivi Jaana Kukkola, Edna Cahill, Michael A. Moskal, Cynthia A. Fink, Steele Ronald Edward, Zouhair F. Stephan, Kevin Poirier
Publikováno v:
Journal of medicinal chemistry. 44(26)
The synthesis and biological activities of biarylamide-substituted diaminoindanes as microsomal triglyceride transfer protein (MTP) inhibitors are described. One of the more potent compounds, 8aR, inhibited both the secretion of apoB from Hep G2 cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0586d5545b1198cefd0a15bfddbac44
https://pubmed.ncbi.nlm.nih.gov/11741485
https://pubmed.ncbi.nlm.nih.gov/11741485
Autor:
Carol Berry, Yumi Sakane, Angelo J. Trapani, Clive G. Diefenbacher, Andrew M. Yuan, Gary Michael Ksander, Raj D. Ghai, Reynalda deJesus
Publikováno v:
Journal of medicinal chemistry. 38(10)
The synthesis of three series of dicarboxylic acid dipeptide neutral endopeptidase 24.11 (NEP) inhibitors is described. In particular, the amino butyramide 21a exhibited potent NEP inhibitory activity (IC50 = 5.0 nM) in vitro and in vivo. Blood level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfde49b64635626fda420705aa8ab574
https://pubmed.ncbi.nlm.nih.gov/7752193
https://pubmed.ncbi.nlm.nih.gov/7752193
Autor:
D. Cote, Mark D. Erion, Gary Michael Ksander, L. El‐Chehabi, N. Levens, Clive Gideon Diefenbacher, Andrew M. Yuan
Publikováno v:
Journal of medicinal chemistry. 37(12)
A variety of compounds were prepared to determine whether dual angiotensin converting enzyme (ACE)/thromboxane synthase (TxS) inhibition could be obtained in the same molecule. These compounds would be used to explore the concept that a dual inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e556e1dde44617ceb671b867de3ac010
https://pubmed.ncbi.nlm.nih.gov/8021921
https://pubmed.ncbi.nlm.nih.gov/8021921
Autor:
Andrew M. Yuan, Clive G. Diefenbacher, Gary Michael Ksander, Yumi Sakane, R. D. Ghai, F. Clark
Publikováno v:
Journal of Medicinal Chemistry. 32:2519-2526
The synthesis of two new series of dicarboxylic acid dipeptides and two sulfhydryl-containing inhibitors are described. The in vitro enkephalinase inhibition data and some in vivo analgesic data are presented for these compounds. For the dibenzylglut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1036e9758c8c753d781d995d5d85e309
https://doi.org/10.1021/jm00132a005
https://doi.org/10.1021/jm00132a005
Publikováno v:
Journal of Medicinal Chemistry. 28:1606-1611
The preparation of two series of N-carbobenzoxy-gamma-D-glutamyl secondary 2S amino acids and (N-substituted gamma-D-glutamyl)indoline-2(S)-carboxylic acid dipeptides is described. In vitro inhibition of angiotensin converting enzyme (ACE) is reporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b1aaf969bfa7f1485f60f51e72fc16
https://doi.org/10.1021/jm00149a011
https://doi.org/10.1021/jm00149a011
Autor:
Frank H. Ebetino, Norbert Gruenfeld, Leslie J. Browne, Candido Gude, Charles F. Huebner, Andrew M. Yuan, James L. Stanton
Publikováno v:
Journal of Medicinal Chemistry. 26:1277-1282
The preparation of a series of 1-glutarylindoline-2(S)-carboxylic acid derivatives, 6a-v and 21a-c, is described. The above compounds were tested for inhibition of angiotensin converting enzyme. The structure-activity relationship of the series is al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788692a8fd5f69e3666a227eb18c787e
https://doi.org/10.1021/jm00363a012
https://doi.org/10.1021/jm00363a012
Autor:
William Macchia, Robert C. Friedmann, Norbert Gruenfeld, Michael H. Ackerman, Joseph E. Babiarz, Andrew M. Yuan, James L. Stanton
Publikováno v:
Chemischer Informationsdienst. 15
The synthesis of N-(3-mercaptopropionyl)-N-arylglycines (14a-x),- N-arylalanines (15a,b),-N-cycloalkylglycines (16a-k), and -1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids (17a-d), -1,2,3,4-tetrahydroquinoline-2-carboxylic acids (18a-f), and -indo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dd79ce76b95842594628bd26a9e671f
https://doi.org/10.1002/chin.198406172
https://doi.org/10.1002/chin.198406172