Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Andrew M. Seacat"'
Autor:
James D. Yager, Andrew M. Seacat, Michael A. Trush, Periannan Kuppusamy, Jay L. Zweier, Yunbo Li
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 518:123-133
The biotransformation of butylated hydroxyanisole (BHA), a possible carcinogenic food antioxidant, includes o-demethylation to 2-tert-butyl(1,4)hydroquinone (TBHQ) which can subsequently be oxidized to 2-tert-butyl(1,4)paraquinone (TBQ). In this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32d58f22cf9ed00357b8eb8b70f74f3
https://doi.org/10.1016/s1383-5718(02)00073-6
https://doi.org/10.1016/s1383-5718(02)00073-6
Publikováno v:
Archives of Biochemistry and Biophysics. 347:45-52
Catechol estrogens are genotoxic, indirectly through redox cycling mechanisms leading to oxidative DNA damage and directly by formation of quinone-DNA adducts. Previously, we demonstrated that Cu2+ can oxidize estradiol (E2) catechols, establishing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09c81e081c94230face8e763adc332e
https://doi.org/10.1006/abbi.1997.0323
https://doi.org/10.1006/abbi.1997.0323
Autor:
James D. Yager, Angelika Tritscher, Thomas R. Sutter, Douglas A. Bell, Brian D. Miller, George W. Lucier, Andrew M. Seacat, John D. Groopman
Publikováno v:
Cancer Letters. 98:219-225
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a more potent hepatocarcinogen in female than in male or ovariectomized rats. A possible mechanism for this increased sensitivity is through enhanced metabolic activation of estrogens by TCDD-induced enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ce8ccdc8e3015b54d18b1d03972dc03
https://doi.org/10.1016/s0304-3835(06)80035-2
https://doi.org/10.1016/s0304-3835(06)80035-2
Autor:
Jean M. Burris, Geary W. Olsen, John W. Froehlich, Larry R. Zobel, John L. Butenhoff, Andrew M. Seacat, David J. Ehresman
Publikováno v:
Environmental Health Perspectives
Perfluorooctanesulfonate [PFOS; CF3(CF2)7SO3−] and its acid salts were derived from perfluorooctanesulfonyl fluoride [POSF; CF3(CF2)7SO2F]. Major product applications were developed using POSF through formation of N-alkylsulfonamides that were used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e703eb53dfe006d19f2d518eec65067
https://pubmed.ncbi.nlm.nih.gov/17805419
https://pubmed.ncbi.nlm.nih.gov/17805419
Autor:
John L. Butenhoff, Andrew M. Seacat, M. W. Anders, Thomas R. Tephly, Daria M. Krenitsky, Lin Xu
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 34(8)
N-Alkylperfluorooctanesulfonamides have been used in a range of industrial and commercial applications. Perfluorooctanesulfonamide (FOSA) is a major metabolite of N-alkylperfluorooctanesulfonamides and has a long half-life in animals and in the envir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c987c2cb1bacd9b2a7ce06e49a7d340d
https://pubmed.ncbi.nlm.nih.gov/16720684
https://pubmed.ncbi.nlm.nih.gov/16720684
Autor:
Geary W. Olsen, Gerald L. Kennedy, Andrew M. Seacat, Lisa B. Biegel, John C. O'Connor, John L. Butenhoff, David G. Farrar, Roger Perkins, Sandra R. Murphy
Publikováno v:
Critical reviews in toxicology. 34(4)
PFOA is a peroxisome proliferator (PPAR agonist) and exerts morphological and biochemical effects characteristic of PPAR agonists. These effects include increased beta-oxidation of fatty acids, increases in several cytochrome P-450 (CYP450)-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1e1ad80b818aecdb6f5f86532c3038
https://pubmed.ncbi.nlm.nih.gov/15328768
https://pubmed.ncbi.nlm.nih.gov/15328768
Autor:
Fred L. DeRoos, John L. Butenhoff, Christopher H. Hurst, Sue S. Tanaka, David J. Waxman, Andrew M. Seacat, Jonathan M. Shipley
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 80(1)
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that activate target genes involved in lipid metabolism, energy homeostasis, and cell differentiation in response to diverse compounds, including environme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb75631219e43d530375828eb9d6b8e
https://pubmed.ncbi.nlm.nih.gov/15071170
https://pubmed.ncbi.nlm.nih.gov/15071170
Autor:
John L. Butenhoff, Sandra R Eldridge, Andrew M. Seacat, Lisa A Clemen, Peter J. Thomford, Cliff Elcombe, Kris J Hansen
Publikováno v:
Toxicology. 183(1-3)
Perfluorooctanesulfonate (PFOS) is a widely disseminated persistent compound found at low (part-per-billion) concentrations in serum and liver samples from humans and fish-eating wildlife. This study investigated the hypotheses that early hepatocellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901ca64693b7956d05020b92a2349cd3
https://pubmed.ncbi.nlm.nih.gov/12504346
https://pubmed.ncbi.nlm.nih.gov/12504346
Publikováno v:
Toxicology. 176(3)
Liver-fatty acid binding protein (L-FABP) is an abundant intracellular lipid-carrier protein. The hypothesis that perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and certain related perfluorooctanesulfonamide-based fluorochemicals (PFOSAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b9f139a369d2f5980ad0a6a072ba23
https://pubmed.ncbi.nlm.nih.gov/12093614
https://pubmed.ncbi.nlm.nih.gov/12093614
Autor:
Andrew M. Seacat, Peter J. Thomford, Geary W. Olsen, John L. Butenhoff, Marvin T. Case, Kris J Hansen
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 68(1)
This study was conducted to determine the earliest measurable response of primates to low-level perfluorooctanesulfonate (PFOS) exposure and to provide information to reduce uncertainty in human health risk assessment. Groups of male and female monke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8796bf831f70d7922ede9e470b3cef43
https://pubmed.ncbi.nlm.nih.gov/12075127
https://pubmed.ncbi.nlm.nih.gov/12075127