Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Andrew M. Schumacher"'
Autor:
Adam C. Searleman, Yajun Ma, Srihari Sampath, Srinath Sampath, Robert Bussell, Eric Y. Chang, Lisa Deaton, Andrew M. Schumacher, Jiang Du
Publikováno v:
Frontiers in Neuroimaging, Vol 3 (2024)
PurposeTo test the ability of inversion-recovery ultrashort echo time (IR-UTE) MRI to directly detect demyelination in mice using a standard cuprizone mouse model.MethodsNon-aqueous myelin protons have ultrashort T2s and are “invisible” with conv
Externí odkaz:
https://doaj.org/article/5da48a42c4554b90af5f0047da063e4a
Autor:
Hank Cheng, Lisa M. Deaton, Minhua Qiu, Sukwon Ha, Reynand Pacoma, Jianmin Lao, Valerie Tolley, Rita Moran, Amber Keeton, John R. Lamb, John Fathman, John R. Walker, Andrew M. Schumacher
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Repeated mild traumatic brain injury (rmTBI) can lead to development of chronic traumatic encephalopathy (CTE), which is characterized by progressive neurodegeneration with presence of white matter damage, gliosis and hyper-phosphorylated tau. While
Externí odkaz:
https://doaj.org/article/277b405ca92b44e9acbaa740b085ee82
Autor:
Tingting Mo, Yefen Zou, Weijun Shen, Zhihong Huang, Xiaoyue Zhang, Qihui Jin, Jing Li, Shifeng Pan, Michael Di Donato, Loren Jon, Andrew M. Schumacher, George Harb, Shanshan Yan, Anwesh Kamireddy, You-Qing Zhang, Tom Y.-H. Wu, Yong Jia, Xueshi Hao, Yahu A. Liu, Richard Glynne, Bryan Laffitte, Brandon Taylor, Peter McNamara, Qiang Ding, Wenqi Gao, Valentina Molteni, Badry Bursalaya, Lisa Deaton, Chun Li
Publikováno v:
ChemMedChem. 15:1562-1570
Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches intended to increase β-cell
Autor:
Bo Liu, Sukwon Ha, H. Michael Petrassi, Kate Jacobsen, George Harb, W. Perry Gordon, Bryan Laffitte, Thanh Lam, Qihui Jin, Yong Jia, Janine E. Baaten, Minhua Qiu, Robert Hill, Shelly Meeusen, Shanshan Yan, Badry Bursulaya, Valentina Molteni, Anwesh Kamireddy, Lisa Deaton, Jianfeng Pan, You-Qing Zhang, Loren Jon, Michael DiDonato, Yahu A. Liu, Shifeng Pan, Andrew M. Schumacher, Tingting Mo, Yefen Zou, Xiaoyue Zhang, Weijun Shen, Karyn Colman, Richard Glynne, Xueshi Hao, Peter McNamara, Vân Nguyen-Tran, Zhicheng Wang, Sheryll Espinola, Bao Nguyen, Tom Y.-H. Wu, Jing Li, Qiang Ding
Publikováno v:
Journal of Medicinal Chemistry. 63:2958-2973
Autoimmune deficiency and destruction in either β-cell mass or function can cause insufficient insulin levels and, as a result, hyperglycemia and diabetes. Thus, promoting β-cell proliferation could be one approach toward diabetes intervention. In
Autor:
Ruhma Syeda, Jie Xu, Adrienne E Dubin, Bertrand Coste, Jayanti Mathur, Truc Huynh, Jason Matzen, Jianmin Lao, David C Tully, Ingo H Engels, H Michael Petrassi, Andrew M Schumacher, Mauricio Montal, Michael Bandell, Ardem Patapoutian
Publikováno v:
eLife, Vol 4 (2015)
Piezo ion channels are activated by various types of mechanical stimuli and function as biological pressure sensors in both vertebrates and invertebrates. To date, mechanical stimuli are the only means to activate Piezo ion channels and whether other
Externí odkaz:
https://doaj.org/article/20a3d73548454cefb9bd2e849079a1d3
Autor:
Cheryl Carson, Pichai Raman, Jennifer Tullai, Lei Xu, Martin Henault, Emily Thomas, Sarita Yeola, Jianmin Lao, Mark McPate, J Martin Verkuyl, George Marsh, Jason Sarber, Adam Amaral, Scott Bailey, Danuta Lubicka, Helen Pham, Nicolette Miranda, Jian Ding, Hai-Ming Tang, Haisong Ju, Pamela Tranter, Nan Ji, Philipp Krastel, Rishi K Jain, Andrew M Schumacher, Joseph J Loureiro, Elizabeth George, Giuliano Berellini, Nathan T Ross, Simon M Bushell, Gül Erdemli, Jonathan M Solomon
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127498 (2015)
Englerin A is a structurally unique natural product reported to selectively inhibit growth of renal cell carcinoma cell lines. A large scale phenotypic cell profiling experiment (CLiP) of englerin A on ¬over 500 well characterized cancer cell lines
Externí odkaz:
https://doaj.org/article/3ef63ce23a0f45a2b040999806a93624
Autor:
Lisa M. Deaton, Minhua Qiu, Sukwon Ha, Hank Cheng, Rita Moran, John Lamb, Reynand Pacoma, Valerie Tolley, John Fathman, Amber Keeton, John R. Walker, Jianmin Lao, Andrew M. Schumacher
Publikováno v:
Neurobiology of Disease, Vol 134, Iss, Pp-(2020)
Repeated mild traumatic brain injury (rmTBI) can lead to development of chronic traumatic encephalopathy (CTE), which is characterized by progressive neurodegeneration with presence of white matter damage, gliosis and hyper-phosphorylated tau. While
Autor:
Reynand Pacoma, Andrew M. Schumacher, Sheldon T. Cheung, Linda C. Hsieh-Wilson, Jason Roland, Jian Liu, Michelle S. Miller
Glycosaminoglycans (GAGs) play critical roles in diverse processes ranging from viral infection to neuroregeneration. Their regiospecific sulfation patterns, which are generated by sulfotransferase enzymes, are key structural determinants that underl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dee315665d78e376e1dd926d946a69a
https://europepmc.org/articles/PMC5896753/
https://europepmc.org/articles/PMC5896753/
Autor:
Weijia Ou, Hugo D. Urbina, Reynand Pacoma, Jennifer L. Harris, Alana Althage, Daniel E. Mason, Andrew M. Schumacher, Juliano Alves, Gus Welzel, Tove Tuntland, Eric C. Peters, James Watson, Laura H. Jacobson, Bo Liu, John R. Walker
Publikováno v:
The Journal of Neuroscience. 33:2457-2464
Accumulation of β-amyloid (Aβ) in the brain is believed to contribute to the pathology of Alzheimer's Disease (AD). Aβ levels are controlled by the production of Aβ from amyloid precursor protein, degradation by proteases, and peripheral clearanc
Autor:
Lynette M. Kilpatrick, Deyi Qiu, Andrew M. Schumacher, Jun Li, Kate A. Owen, Jennifer L. Harris, Juliano Alves, Vincent Ellis
Publikováno v:
Biochemical Journal. 426:219-228
HGF (hepatocyte growth factor) is a pleiotropic cytokine homologous to the serine protease zymogen plasminogen that requires canonical proteolytic cleavage to gain functional activity. The activating proteases are key components of its regulation, bu