Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Andrew M. Scharenberg"'
Autor:
Moritz J. Schmidt, Ashish Gupta, Christien Bednarski, Stefanie Gehrig-Giannini, Florian Richter, Christian Pitzler, Michael Gamalinda, Christina Galonska, Ryo Takeuchi, Kui Wang, Caroline Reiss, Kerstin Dehne, Michael J. Lukason, Akiko Noma, Cindy Park-Windhol, Mariacarmela Allocca, Albena Kantardzhieva, Shailendra Sane, Karolina Kosakowska, Brian Cafferty, Jan Tebbe, Sarah J. Spencer, Scott Munzer, Christopher J. Cheng, Abraham Scaria, Andrew M. Scharenberg, André Cohnen, Wayne M. Coco
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/ea3084e9d59245a1998e55dd20e1cb3d
Autor:
Moritz J. Schmidt, Ashish Gupta, Christien Bednarski, Stefanie Gehrig-Giannini, Florian Richter, Christian Pitzler, Michael Gamalinda, Christina Galonska, Ryo Takeuchi, Kui Wang, Caroline Reiss, Kerstin Dehne, Michael J. Lukason, Akiko Noma, Cindy Park-Windhol, Mariacarmela Allocca, Albena Kantardzhieva, Shailendra Sane, Karolina Kosakowska, Brian Cafferty, Jan Tebbe, Sarah J. Spencer, Scott Munzer, Christopher J. Cheng, Abraham Scaria, Andrew M. Scharenberg, André Cohnen, Wayne M. Coco
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Abstract Streptococcus pyogenes (Spy) Cas9 has potential as a component of gene therapeutics for incurable diseases. One of its limitations is its large size, which impedes its formulation and delivery in therapeutic applications. Smaller Cas9s are a
Externí odkaz:
https://doaj.org/article/164ce27f7fcc420f8085cc9624163a4b
Autor:
Sowmya Pattabhi, Samantha N. Lotti, Mason P. Berger, Swati Singh, Christopher T. Lux, Kyle Jacoby, Calvin Lee, Olivier Negre, Andrew M. Scharenberg, David J. Rawlings
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 17, Iss , Pp 277-288 (2019)
Gene editing following designer nuclease cleavage in the presence of a DNA donor template can revert mutations in disease-causing genes. For optimal benefit, reversion of the point mutation in HBB leading to sickle cell disease (SCD) would permit pre
Externí odkaz:
https://doaj.org/article/5c5d0cc4529c44adb9273c8f4a9f26d9
Autor:
Olivier Humbert, Frieda Chan, Yogendra S. Rajawat, Troy R. Torgerson, Christopher R. Burtner, Nicholas W. Hubbard, Daniel Humphrys, Zachary K. Norgaard, Patricia O'Donnell, Jennifer E. Adair, Grant D. Trobridge, Andrew M. Scharenberg, Peter J. Felsburg, David J. Rawlings, Hans-Peter Kiem
Publikováno v:
Blood Advances, Vol 2, Iss 9, Pp 987-999 (2018)
Abstract: Hematopoietic stem-cell gene therapy is a promising treatment of X-linked severe combined immunodeficiency disease (SCID-X1), but currently, it requires recipient conditioning, extensive cell manipulation, and sophisticated facilities. With
Externí odkaz:
https://doaj.org/article/3e55cf5967d441c1ad4a379d1df78d1a
Autor:
Malika Hale, Baeckseung Lee, Yuchi Honaker, Wai-Hang Leung, Alexandra E. Grier, Holly M. Jacobs, Karen Sommer, Jaya Sahni, Shaun W. Jackson, Andrew M. Scharenberg, Alexander Astrakhan, David J. Rawlings
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 192-203 (2017)
Gene editing by homology-directed recombination (HDR) can be used to couple delivery of a therapeutic gene cassette with targeted genomic modifications to generate engineered human T cells with clinically useful profiles. Here, we explore the functio
Externí odkaz:
https://doaj.org/article/5c8a965f6c324b0c809e18b4b234bc06
Autor:
Julianne Smith, Andrew M. Scharenberg, Martin Pule, Karl Peggs, Sylvain Arnould, Agnès Gouble, Aymeric Duclert, Gordon Weng-Kit Cheung, Justin Eyquem, Céline Lebuhotel, Roman Galetto, Laetitia Lemaire, Cécile Bas, Pierrick Potrel, Sophie Derniame, Isabelle Chion-Sotinel, Diane Le Clerre, Cécile Schiffer-Mannioui, Brian Philip, Laurent Poirot
Supplementary figure S1 : Gene disruption analysis in HEK293 cells. Supplementary figure S2: Optimization of the generation of double KO cells Supplementary table S1: Deep sequencing analysis of TCR-negative cells Supplementary figure S3: Representat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8a0d2010b9ea79650e3d9bcec08e56
https://doi.org/10.1158/0008-5472.22407593
https://doi.org/10.1158/0008-5472.22407593
Autor:
Julianne Smith, Andrew M. Scharenberg, Martin Pule, Karl Peggs, Sylvain Arnould, Agnès Gouble, Aymeric Duclert, Gordon Weng-Kit Cheung, Justin Eyquem, Céline Lebuhotel, Roman Galetto, Laetitia Lemaire, Cécile Bas, Pierrick Potrel, Sophie Derniame, Isabelle Chion-Sotinel, Diane Le Clerre, Cécile Schiffer-Mannioui, Brian Philip, Laurent Poirot
Adoptive immunotherapy using autologous T cells endowed with chimeric antigen receptors (CAR) has emerged as a powerful means of treating cancer. However, a limitation of this approach is that autologous CAR T cells must be generated on a custom-made
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282e688c4450e87665a4af1443c9b0b0
https://doi.org/10.1158/0008-5472.c.6507341
https://doi.org/10.1158/0008-5472.c.6507341
Autor:
Julianne Smith, Andrew M. Scharenberg, Martin Pule, Karl Peggs, Sylvain Arnould, Agnès Gouble, Aymeric Duclert, Gordon Weng-Kit Cheung, Justin Eyquem, Céline Lebuhotel, Roman Galetto, Laetitia Lemaire, Cécile Bas, Pierrick Potrel, Sophie Derniame, Isabelle Chion-Sotinel, Diane Le Clerre, Cécile Schiffer-Mannioui, Brian Philip, Laurent Poirot
Supplementary Methods from Multiplex Genome-Edited T-cell Manufacturing Platform for “Off-the-Shelf” Adoptive T-cell Immunotherapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272179729b5359c94ee135c663060231
https://doi.org/10.1158/0008-5472.22407590
https://doi.org/10.1158/0008-5472.22407590
Autor:
Bo Huang, Suilan Zheng, Haiyan Chu, Ramesh Mukkamala, Suresh K. Bowroju, Yashapal Singh, Sudarsan R. Kasireddy, Md Sazzadul Bari, Madduri Srinivasarao, Laurie Beitz, Byoung Ryu, Michael Jensen, Andrew M. Scharenberg, Philip S. Low
Publikováno v:
Cancer Research. 83:4099-4099
CAR T cell therapies have demonstrated considerable potency in treating hematologic cancers, but only limited efficacy in eliminating solid tumors. One reason for this discrepancy may derive from the immunologic and physical barriers created by infil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ccbce2727f866bb50598e6d6f9c9ab6
https://doi.org/10.1158/1538-7445.am2023-4099
https://doi.org/10.1158/1538-7445.am2023-4099
Autor:
Kathryn R Michels, Alyssa Sheih, Susana A Hernandez, Alissa H Brandes, Don Parrilla, Blythe Irwin, Anai M Perez, Hung-An Ting, Christopher J Nicolai, Timothy Gervascio, Seungjin Shin, Mark D Pankau, Mason Muhonen, Jessica Freeman, Sarah Gould, Rich Getto, Ryan P Larson, Byoung Y Ryu, Andrew M Scharenberg, Alessandra M Sullivan, Shon Green
Publikováno v:
Journal for ImmunoTherapy of Cancer. 11:e006292
BackgroundChimeric antigen receptor (CAR) T-cell therapies have demonstrated transformational outcomes in the treatment of B-cell malignancies, but their widespread use is hindered by technical and logistical challenges associated with ex vivo cell m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c522fecb39d10b75cb27d68ee4c68604
https://doi.org/10.1136/jitc-2022-006292
https://doi.org/10.1136/jitc-2022-006292