Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Andrew M. Pickering"'
Autor:
Harper S. Kim, Danitra J. Parker, Madison M. Hardiman, Erin Munkácsy, Nisi Jiang, Aric N. Rogers, Yidong Bai, Colin Brent, James A. Mobley, Steven N. Austad, Andrew M. Pickering
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Protein translation (PT) declines with age in invertebrates, rodents, and humans. It has been assumed that elevated PT at young ages is beneficial to health and PT ends up dropping as a passive byproduct of aging. In Drosophila, we show that
Externí odkaz:
https://doaj.org/article/9b7c7453c2704f3090c9123524769e52
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)
TrxR2 overexpression in mice enhances metabolism and prevents high-fat diet induced metabolic deficits in mice through alteration in function of several enzymes in the tricarboxylic acid cycle and complexes of the electron transport chain.
Externí odkaz:
https://doaj.org/article/b14f713e241845ca819bb151140f98b3
Autor:
Kanisa Davidson, Andrew M. Pickering
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
The proteasome is a large multi-subunit protease responsible for the degradation and removal of oxidized, misfolded, and polyubiquitinated proteins. The proteasome plays critical roles in nervous system processes. This includes maintenance of cellula
Externí odkaz:
https://doaj.org/article/996bbe1ea40143898fc66f18e78131ff
Autor:
Harper S. Kim, John Son, Donghwan Lee, Joy Tsai, Danny Wang, E. Sandra Chocron, Seongwoo Jeong, Pamela Kittrell, Charles F. Murchison, Richard E. Kennedy, Alejandro Tobon, Carlayne E. Jackson, Andrew M. Pickering
Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-19 (2022)
Abstract Background Prior studies on the role of gut-microbiome in Amyotrophic Lateral Sclerosis (ALS) pathogenesis have yielded conflicting results. We hypothesized that gut- and oral-microbiome may differentially impact two clinically-distinct ALS
Externí odkaz:
https://doaj.org/article/60dbb1c4887c44839d8512a58bdef49b
Autor:
Harper S. Kim, Andrew M. Pickering
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Protein translation is an essential cellular process playing key roles in growth and development. Protein translation declines over the course of age in multiple animal species, including nematodes, fruit flies, mice, rats, and even humans. In all th
Externí odkaz:
https://doaj.org/article/d44222f78c9040678d6b9e7fe8ae815e
Autor:
Paweł A. Osmulski, Przemysław Karpowicz, Elżbieta Jankowska, Jonathan Bohmann, Andrew M. Pickering, Maria Gaczyńska
Publikováno v:
Molecules, Vol 25, Iss 6, p 1439 (2020)
The proteasome is a pivotal element of controlled proteolysis, responsible for the catabolic arm of proteostasis. By inducing apoptosis, small molecule inhibitors of proteasome peptidolytic activities are successfully utilized in treatment of blood c
Externí odkaz:
https://doaj.org/article/d328f8e0769f499a92cc77f238bfa16b
Autor:
E. Sandra Chocron, Erin Munkácsy, Harper S. Kim, Przemyslaw Karpowicz, Nisi Jiang, Candice E. Van Skike, Nicholas DeRosa, Andy Q. Banh, Juan P. Palavicini, Paweł Wityk, Leszek Kalinowski, Veronica Galvan, Pawel A. Osmulski, Elzbieta Jankowska, Maria Gaczynska, Andrew M. Pickering
Publikováno v:
Science Advances. 8
The proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s diseas
Autor:
Sarah Owen, Janusz Franco-Barraza, Vaibhav Sahai, Theodore S. Lawrence, Sunitha Nagrath, Jiaqi Shi, Edna Cukierman, Anjali Mittal, Mara H. Sherman, Ziwen Zhu, Noah Meurs, Anirban Maitra, Andrew M. Pickering, Olamide Animasahun, Meredith A. Morgan, Abhinav Achreja, Deepak Nagrath, Ting Wen Lo, Valerie Gunchick, Pooja Parikh
Publikováno v:
Nature metabolism
Branched-chain amino acids (BCAAs) supply both carbon and nitrogen in pancreatic cancers, and increased levels of BCAAs have been associated with increased risk of pancreatic ductal adenocarcinomas (PDACs). It remains unclear, however, how stromal ce
Autor:
Andrew M. Pickering, Pawel A. Osmulski, Przemysław Karpowicz, Elżbieta Jankowska, Jonathan Bohmann, Maria Gaczynska
Publikováno v:
Molecules, Vol 25, Iss 6, p 1439 (2020)
Molecules
Volume 25
Issue 6
Molecules
Volume 25
Issue 6
The proteasome is a pivotal element of controlled proteolysis, responsible for the catabolic arm of proteostasis. By inducing apoptosis, small molecule inhibitors of proteasome peptidolytic activities are successfully utilized in treatment of blood c
Publikováno v:
Aging Cell
Summary In a survey of enzymes related to protein oxidation and cellular redox state, we found activity of the redox enzyme thioredoxin reductase (TXNRD) to be elevated in cells from long‐lived species of rodents, primates, and birds. Elevated TXNR