Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Andrew M. Mason"'
Autor:
Jak Grimes, Sapna Desai, Neil W. Charter, James Lodge, Rita Moita Santos, Albert Isidro‐Llobet, Andrew M. Mason, Zining Wu, Lawrence A. Wolfe III, Lakshmi Anantharaman, Andrew Green, Angela M. Bridges, Deidre A. Dalmas Wilk, Andrew J. Brown
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 6, Pp n/a-n/a (2019)
Abstract Activation of MrgX2, an orphan G protein‐coupled receptor expressed on mast cells, leads to degranulation and histamine release. Human MrgX2 binds promiscuously to structurally diverse peptides and small molecules that tend to have basic p
Externí odkaz:
https://doaj.org/article/d52477c4710a45b380964101c0429cd7
Autor:
Andrew M. Mason
Publikováno v:
Case Reports in Medicine, Vol 2009 (2009)
A case series of five patients is described demonstrating the utility of the intubating laryngeal mask airway in the prehospital setting, both as a primary airway rescue device and as a bridge to tracheal intubation. All patients were hypoxaemic, had
Externí odkaz:
https://doaj.org/article/2e1e6687f1b84b0ca7bb1b75c4e6a461
Autor:
Mark R. Harpel, Ghotas Evindar, Shenaz Bunally, David G. Washburn, Steve Wilson, Joanne Prendergast, Scott G. Summerfield, Katrina Rivera, Chun-wa Chung, Julien C. Vantourout, Steven R. Skinner, Neil Young, Xiaopeng Bai, Christopher C. Arico-Muendel, Albert Isidro-Llobet, Rakesh Lad, William Traylen, Graham L. Simpson, Josephine Yuen, Letian Kuai, Paul Scott-Stevens, Kim Lambert, Sandeep Pal, Saul Needle, Andrew M. Mason, Michael J Hobbs, Emma V. Edgar, Richard Snell, Lara S. Kallander, Eric X Shi, Lisa M. Shewchuk, Dennis A. Holt, Allan J. B. Watson
Publikováno v:
Bioconjugate Chemistry. 32:279-289
Reducing the required frequence of drug dosing can improve the adherence of patients to chronic treatments. Hence, drugs with longer in vivo half-lives are highly desirable. One of the most promising approaches to extend the in vivo half-life of drug
Autor:
Joseph Redshaw, Adam Taylor, Alex Brown, Andrew M. Mason, Magnus W. D. Hanson-Heine, Jonathan D. Hirst, Alexe L. Haywood, Thomas Gärtner
The use of machine learning methods for the prediction of reaction yield is an emerging area. We demonstrate the applicability of support vector regression (SVR) for predicting reaction yields, using combinatorial data. Molecular descriptors used in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac173a81b9e660e2005850791e9a090
https://doi.org/10.26434/chemrxiv.14346920
https://doi.org/10.26434/chemrxiv.14346920
© 2020 The Authors. Peptide Science published by Wiley Periodicals, Inc. Stabilised peptides are now established as potential drug candidates to probe previously intractable molecular targets, such as protein-protein interactions. Herein, we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a138d555d54ade64b1c7e25da537aa
https://strathprints.strath.ac.uk/71917/1/Watson_etal_PS_2020_Design_synthesis_and_evaluation_of_E2_25K_derived_stapled_peptides.pdf
https://strathprints.strath.ac.uk/71917/1/Watson_etal_PS_2020_Design_synthesis_and_evaluation_of_E2_25K_derived_stapled_peptides.pdf
Autor:
Joseph Redshaw, Andrew M. Mason, Alexe L. Haywood, Adam Taylor, Thomas Gaertner, Jonathan D. Hirst
The synthesis of new molecules is essential for progress in various sectors within the chemical industry and academia. Medicinal and materials chemistry are two examples. Searching through vast regions of chemical space for routes to new molecules is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3585558677b9fd7c4774d83e36cc9d17
https://doi.org/10.1039/9781839160233-00169
https://doi.org/10.1039/9781839160233-00169
Autor:
Naomi R. Prentice, Jeffrey A. Messer, Thomas O’Keeffe, Zhengrong Zhu, LaShadric C. Grady, Sandeep Pal, Praew Thansandote, Andrew M. Mason, Alex Shaginian, Xiangguo E. Shi, Ghotas Evindar, Robert N. Bream, Graham L. Simpson, Christopher P. Davie
Publikováno v:
ACS Chemical Biology. 13:53-59
A DNA-encoded macrocyclic peptide library was designed and synthesized with 2.4 × 1012 members composed of 4–20 natural and non-natural amino acids. Affinity-based selection was performed against two therapeutic targets, VHL and RSV N protein. On
Autor:
Zining Wu, Lawrence Wolfe, Andrew R. Green, Deidre Dalmas Wilk, Neil Charter, Jak Grimes, Rita Moita Santos, Albert Isidro Llobet, Andrew M. Mason, Sapna Desai, Andrew J. Brown
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 99:106595
Publikováno v:
Tetrahedron Letters. 52:2258-2261
Thermolysis of 6,6′-(2-oxopropane-1,3-diyl)bis(2,2-dimethyl-4H-1,3-dioxin-4-one) in the presence of methanol gave a triketo-ester which subsequently aromatized to provide a synthetically useful homophthalate ester. Enolate C-acylation in the presen
Autor:
Alan D. Borthwick, Marie Charbaut, Robert J. Young, Máire A. Convery, Ivan Leo Pinto, Andrew M. Mason, Weston Helen Elisabeth, Matthew Campbell, David W. Brown, Anthony J. Pateman, Henry Anderson Kelly, Derek Pollard, Shah Gita Punjabhai, John R. Toomey, N. Paul King, Stefan Senger, Eric Hortense, Ping Zhou, Hawa Diallo, Nigel S. Watson, Wendy R. Irving, Angela Patikis, Cynthia L. Burns-Kurtis, Savvas Kleanthous, Chuen Chan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:28-33
Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating basic biaryl P4 groups, producing highly potent inhibitors with significant anticoagulant activitie