Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Andrew M. Lipczynski"'
Autor:
Van D. Reif, Stephen C. Eyley, Andrew M. Lipczynski, Simon Golec, Pat Sandra, Kevin L. Facchine, Edward J. Delaney, David P. Elder, Rolf Schulte Oestrich, Wilfried Hoffmann, Andrew Teasdale, Karine Jacq, Karen Taylor-Worth, Frank David
Publikováno v:
Organic Process Research & Development. 14:999-1007
Sulfonate esters of lower alcohols possess the capacity to react with DNA and cause mutagenic events, which in turn may be cancer inducing. Consequently, the control of residues of such substances in products that may be ingested by man (in food or p
Autor:
Stephen C. Eyley, Rolf Schulte Oestrich, David P. Elder, Andrew Teasdale, Karen Taylor-Worth, Ed Delaney, Andrew M. Lipczynski, Frank David, Kevin L. Facchine, Patrick Sandra, Van D. Reif, Karine Jacq, Simon Golec
Publikováno v:
Organic Process Research & Development. 13:429-433
Sulfonate salts offer useful modification of physicochemical properties of active pharmaceutical ingredients (APIs) containing basic groups, but there are regulatory concerns over the presence of sulfonate esters as potential genotoxic impurities (PG
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 48:497-507
This paper continues the review of the relevant scientific literature associated with the control and analysis of potential genotoxic impurities (PGIs) in active pharmaceutical ingredients (APIs). The initial review [D.P. Elder, A. Teasdale, A.M. Lip
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 46:1-8
This article reviews current regulatory guidelines and relevant scientific literature pertaining to the control and analysis of potential genotoxic impurities (PGIs) in new active pharmaceutical ingredients (APIs) with specific reference to a certain
Autor:
Andrew M. Lipczynski, Roberto Alzaga, Karen Taylor-Worth, Robert W. Ryan, Roman Szucs, Pat Sandra
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 45:472-479
A simple, reliable and fast procedure for the simultaneous determination of residues of some common alkylating agents (AAs), such as mesylates, besylates, tosylates and sulfates, employed in drug synthesis, has been developed by in situ derivatizatio
Autor:
Martin A. Kelly, Roman Szucs, Jon V. Beaman, P.a. Hailey, Steve P. Gee, Paul D. Ferguson, Karen A. Taylor, Andrew M. Lipczynski, Isabelle Caron
Publikováno v:
Journal of Microcolumn Separations. 12:568-576
A generic approach to chiral separations using capillary electrophoresis is outlined. The generic method was developed by investigating the interactions of charged (sulfobutyl ether-β-cyclodextrin, SBE-β-CD) and neutral cyclodextrins (primarily γ-
Publikováno v:
Journal of Chromatography A. 836:53-58
An alternative approach to the separation of hydrophobic compounds by electrokinetic chromatography using a negatively charged cyclodextrin, sulfobutyl ether-β-cyclodextrin (SBE-β-CD), as a pseudostationary phase is described. While the separation
Publikováno v:
Journal of High Resolution Chromatography. 22:59-62
Autor:
Andrew M. Lipczynski, Pat Sandra, Andrew Teasdale, Simon Golec, Kevin L. Facchine, Karine Jacq, Ed Delaney, Karen Taylor-Worth, Steve Eyley, Van D. Reif, Rolf Schulte Oestrich, Frank David, David P. Elder
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 48(5)
An automated sample preparation and analysis procedure was developed to monitor the formation of ethyl methane sulfonate from reaction mixtures containing ethanol and methane sulfonic acid. The system is based on a liquid handling robot combined with
Autor:
Andrew M. Lipczynski
Publikováno v:
The Analyst. 112(4)
The determination of benzylpenicillin and its acid-base degradation products by ion-suppression, ion-pair and buffered reversed-phase HPLC separation modes are compared. The latter technique is the preferred method of determination. The effects on sa