Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Andrew M. Lipchik"'
Autor:
Kevin Van Bortle, David P. Marciano, Qing Liu, Tristan Chou, Andrew M. Lipchik, Sanjay Gollapudi, Benjamin S. Geller, Emma Monte, Rohinton T. Kamakaka, Michael P. Snyder
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
RNA polymerase III changes its subunit composition during mammalian development. Here the authors report that loss of subunit POLR3G, which re-emerges in cancer, promotes expression of small NF90-associated RNA (snaR-A), a noncoding RNA implicated in
Externí odkaz:
https://doaj.org/article/d5d5e04e9f0d4ba195049ff05b893451
Autor:
Joshua J. Gruber, Justin Chen, Benjamin Geller, Natalie Jäger, Andrew M. Lipchik, Guangwen Wang, Allison W. Kurian, James M. Ford, Michael P. Snyder
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 2182-2193.e6 (2019)
Summary: Individuals with a single functional copy of the BRCA2 tumor suppressor have elevated risks for breast, ovarian, and other solid tumor malignancies. The exact mechanisms of carcinogenesis due to BRCA2 haploinsufficiency remain unclear, but o
Externí odkaz:
https://doaj.org/article/7dc03d967b894aa89947d5be4b54068b
Autor:
Jitender D. Gaddameedi, Tristan Chou, Benjamin S. Geller, Amithvikram Rangarajan, Tarun A. Swaminathan, Danielle Dixon, Katherine Long, Caiden J. Golder, Van A. Vuong, Selene Banuelos, Robert Greenhouse, Michael P. Snyder, Andrew M. Lipchik, Joshua J. Gruber
Publikováno v:
Journal of Medicinal Chemistry. 66:5774-5801
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9e3f4382327fd01bd7c4a377634370c
https://doi.org/10.1021/acs.jmedchem.3c00039
https://doi.org/10.1021/acs.jmedchem.3c00039
Autor:
W. Todd Miller, Heng Wu, Robert A. Burton, Carol Beth Post, Andrew M. Lipchik, Huaping Mo, Mehul Joshi, Barbara P. Craddock, Laurie L. Parker
Publikováno v:
Protein Sci
Most signal transduction pathways in humans are regulated by protein kinases through phosphorylation of their protein substrates. Typical eukaryotic protein kinases are of two major types: those that phosphorylate-specific sequences containing tyrosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a77115ca18de6f8b0e5b8a98c50bb71f
https://doi.org/10.1002/pro.3777
https://doi.org/10.1002/pro.3777
Autor:
Monte E, Andrew M. Lipchik, Snyder M, Van Bortle K, Benjamin Geller, David Marciano, Rohinton T. Kamakaka, Qing Liu, Gollapudi S
Dysregulation of the RNA polymerase III (Pol III) transcription program, which synthesizes tRNA and other classes of small noncoding RNA critical for cell growth and proliferation, is associated with cancer and human disease. Previous studies have id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a23ee9dcacea2ebd9692aa4c308d7a7
https://doi.org/10.1101/2021.04.21.440535
https://doi.org/10.1101/2021.04.21.440535
Autor:
Wing Hung Wong, Hongchao Guo, Chenchen Zhu, Ming-Shian Tsai, Takaaki Furihata, Nathaniel Watson, Chao Jiang, Lei Tian, Andrew M. Lipchik, Joshua J. Gruber, Michael Snyder, Kevin Van Bortle, Haodi Wu, David Marciano, Yingxin Li, Eric X Wei, Joseph C. Wu, Zhana Duren, Qing-Jun Luo, Brittany Lee-McMullen, Mark A. Kay, Bingqing Zhao, Lars M. Steinmetz, Ming-Tao Zhao, Anil Narasimha, Jun Liu, Qing Liu
SUMMARYMaternal drug exposure during pregnancy increases the risks of developmental cardiotoxicity, leading to congenital heart defects (CHDs). In this study, we used human stem cells as anin-vitrosystem to interrogate the mechanisms underlying drug-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8fa29c03d850439b80ce5ab0d56df6
Publikováno v:
Cancer Research. 79:P3-05
This abstract was not presented at the conference. Citation Format: Gruber JJ, Chen J, Geller B, Jager N, Lipchik AM, Snyder MP. Not presented [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0cfee2cab27974ee7f666ae83514713
https://doi.org/10.1158/1538-7445.sabcs18-p3-05-02
https://doi.org/10.1158/1538-7445.sabcs18-p3-05-02
Autor:
James M. Ford, Joshua J. Gruber, Ashwin N. Ram, Michael Snyder, Ameen A. Salahudeen, Andrew M. Lipchik, Benjamin Geller, Justin Chen, Calvin J. Kuo
SummaryThe energetic costs of duplicating chromatin along with DNA replication are large and therefore likely depend on nutrient sensing checkpoints and metabolic inputs. By studying chromatin modifiers regulated by epithelial growth factor, we ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5080188e6c0559adfc9936d7c9eae26c
Publikováno v:
Journal of the Endocrine Society
Chronic low-grade inflammation and mitochondrial dysfunction are hallmarks of insulin resistance. However, the mechanisms by which the immune system can propagate systemic insulin resistance remains poorly understood. IgG antibodies are a critical co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc346968fc4a441f19ecdd28ba53c51
https://doi.org/10.1210/jendso/bvab048.905
https://doi.org/10.1210/jendso/bvab048.905
Publikováno v:
Analytical Chemistry. 87:7555-7558
Kinase signaling is a major mechanism driving many cancers. While many inhibitors have been developed and are employed in the clinic, resistance due to crosstalk and pathway reprogramming is an emerging problem. High-throughput assays to detect multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47913d428f92e60bc619e4f005c24e70
https://doi.org/10.1021/acs.analchem.5b02233
https://doi.org/10.1021/acs.analchem.5b02233