Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Andrew M. James"'
Autor:
Cyril Besnard, Ali Marie, Sisini Sasidharan, Hans Deyhle, Andrew M. James, Sharif I. Ahmed, Christina Reinhard, Robert A. Harper, Richard M. Shelton, Gabriel Landini, Alexander M. Korsunsky
Publikováno v:
Chemical & Biomedical Imaging, Vol 2, Iss 3, Pp 222-232 (2024)
Externí odkaz:
https://doaj.org/article/d30f7d4420b44087a43a8dfc9f8cf0c4
Autor:
Jan Lj. Miljkovic, Nils Burger, Justyna M. Gawel, John F. Mulvey, Abigail A.I. Norman, Takanori Nishimura, Yoshiyuki Tsujihata, Angela Logan, Olga Sauchanka, Stuart T. Caldwell, Jordan L. Morris, Tracy A. Prime, Stefan Warrington, Julien Prudent, Georgina R. Bates, Dunja Aksentijević, Hiran A. Prag, Andrew M. James, Thomas Krieg, Richard C. Hartley, Michael P. Murphy
Publikováno v:
Redox Biology, Vol 55, Iss , Pp 102429- (2022)
Mitochondria-targeted H2S donors are thought to protect against acute ischemia-reperfusion (IR) injury by releasing H2S that decreases oxidative damage. However, the rate of H2S release by current donors is too slow to be effective upon administratio
Externí odkaz:
https://doaj.org/article/f01616a12f704ac39a2ca4515711e427
Autor:
Anja V. Gruszczyk, Alva M. Casey, Andrew M. James, Hiran A. Prag, Nils Burger, Georgina R. Bates, Andrew R. Hall, Fay M. Allen, Thomas Krieg, Kourosh Saeb-Parsy, Michael P. Murphy
Publikováno v:
Redox Biology, Vol 54, Iss , Pp 102368- (2022)
Cell models of cardiac ischemia-reperfusion (IR) injury are essential to facilitate understanding, but current monolayer cell models poorly replicate the in vivo IR injury that occurs within a three-dimensional tissue. Here we show that this is for t
Externí odkaz:
https://doaj.org/article/6473c0db19b24a889ec6d16509ca913e
Autor:
Zhan Yin, Nils Burger, Duvaraka Kula-Alwar, Dunja Aksentijević, Hannah R. Bridges, Hiran A. Prag, Daniel N. Grba, Carlo Viscomi, Andrew M. James, Amin Mottahedin, Thomas Krieg, Michael P. Murphy, Judy Hirst
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Reactive oxygen species (ROS) production by reverse electron transfer (RET) through complex I is thought to cause tissue damage from heart attacks. Here, the authors combine in vivo work with biochemical and cryo-EM analyses to characterize the effec
Externí odkaz:
https://doaj.org/article/1317dd8d29fd49259db11814845c32ea
Autor:
Silvia Galván-Peña, Richard G. Carroll, Carla Newman, Elizabeth C. Hinchy, Eva Palsson-McDermott, Elektra K. Robinson, Sergio Covarrubias, Alan Nadin, Andrew M. James, Moritz Haneklaus, Susan Carpenter, Vincent P. Kelly, Michael P. Murphy, Louise K. Modis, Luke A. O’Neill
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Host metabolic reprogramming plays a role in functional responses against pathogens. Here, the authors characterise malonylated proteins in macrophages and show that malonylation of the glycolytic enzyme GAPDH impacts cytokine production by modulatin
Externí odkaz:
https://doaj.org/article/4a15ae022f184e95bae97dad5d2e7a5a
Autor:
Timothy E. Beach, Hiran A. Prag, Laura Pala, Angela Logan, Margaret M. Huang, Anja V. Gruszczyk, Jack L. Martin, Krishnaa Mahbubani, Mazin O. Hamed, Sarah A. Hosgood, Michael L. Nicholson, Andrew M. James, Richard C. Hartley, Michael P. Murphy, Kourosh Saeb-Parsy
Publikováno v:
Redox Biology, Vol 36, Iss , Pp 101640- (2020)
Renal ischemia reperfusion (IR) injury leads to significant patient morbidity and mortality, and its amelioration is an urgent unmet clinical need. Succinate accumulates during ischemia and its oxidation by the mitochondrial enzyme succinate dehydrog
Externí odkaz:
https://doaj.org/article/038ddcdac34144049d5f8e694c7a30c8
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1445-1455 (2018)
Summary: Acetyl-coenzyme A (CoA) is an abundant metabolite that can also alter protein function through non-enzymatic N-acetylation of protein lysines. This N-acetylation is greatly enhanced in vitro if an adjacent cysteine undergoes initial S-acetyl
Externí odkaz:
https://doaj.org/article/2968c8493b4446f0b0d11137e82e113f
Autor:
Andrew M. James, Kurt Hoogewijs, Angela Logan, Andrew R. Hall, Shujing Ding, Ian M. Fearnley, Michael P. Murphy
Publikováno v:
Cell Reports, Vol 18, Iss 9, Pp 2105-2112 (2017)
Summary: Acetyl coenzyme A (AcCoA), a key intermediate in mitochondrial metabolism, N-acetylates lysine residues, disrupting and, in some cases, regulating protein function. The mitochondrial lysine deacetylase Sirtuin 3 (Sirt3) reverses this modific
Externí odkaz:
https://doaj.org/article/fd9888f6e25e4dfb9bb330d5437d5477
Autor:
Katja E. Menger, Andrew M. James, Helena M. Cochemé, Michael E. Harbour, Edward T. Chouchani, Shujing Ding, Ian M. Fearnley, Linda Partridge, Michael P. Murphy
Publikováno v:
Cell Reports, Vol 11, Iss 12, Pp 1856-1865 (2015)
Altering the redox state of cysteine residues on protein surfaces is an important response to environmental challenges. Although aging and fasting alter many redox processes, the role of cysteine residues is uncertain. To address this, we used a redo
Externí odkaz:
https://doaj.org/article/469493a6ca604f91884c912cdf9e4a0b
Autor:
Fay M. Allen, Ana S. H. Costa, Anja V. Gruszczyk, Georgina R. Bates, Hiran A. Prag, Efterpi Nikitopoulou, Carlo Viscomi, Christian Frezza, Andrew M. James, Michael P. Murphy
Publikováno v:
FEBS Letters. 597:246-261
The compartmentation and distribution of metabolites between mitochondria and the rest of the cell is a key parameter of cell signalling and pathology. Here, we have developed a rapid fractionation procedure that enables us to take mouse heart and li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a036ce92dfdabda851ab873f79be1a73
https://doi.org/10.1002/1873-3468.14511
https://doi.org/10.1002/1873-3468.14511