The DIAD Approach to Correlative Synchrotron X‑ray Imaging and Diffraction Analysis of Human Enamel

Autor: Cyril Besnard, Ali Marie, Sisini Sasidharan, Hans Deyhle, Andrew M. James, Sharif I. Ahmed, Christina Reinhard, Robert A. Harper, Richard M. Shelton, Gabriel Landini, Alexander M. Korsunsky

Publikováno v: Chemical & Biomedical Imaging, Vol 2, Iss 3, Pp 222-232 (2024)

Externí odkaz: https://doaj.org/article/d30f7d4420b44087a43a8dfc9f8cf0c4

Mitochondrial metabolism and bioenergetic function in an anoxic isolated adult mouse cardiomyocyte model of in vivo cardiac ischemia-reperfusion injury

Autor: Anja V. Gruszczyk, Alva M. Casey, Andrew M. James, Hiran A. Prag, Nils Burger, Georgina R. Bates, Andrew R. Hall, Fay M. Allen, Thomas Krieg, Kourosh Saeb-Parsy, Michael P. Murphy

Publikováno v: Redox Biology, Vol 54, Iss , Pp 102368- (2022)

Cell models of cardiac ischemia-reperfusion (IR) injury are essential to facilitate understanding, but current monolayer cell models poorly replicate the in vivo IR injury that occurs within a three-dimensional tissue. Here we show that this is for t

Externí odkaz: https://doaj.org/article/6473c0db19b24a889ec6d16509ca913e

Malonylation of GAPDH is an inflammatory signal in macrophages

Autor: Silvia Galván-Peña, Richard G. Carroll, Carla Newman, Elizabeth C. Hinchy, Eva Palsson-McDermott, Elektra K. Robinson, Sergio Covarrubias, Alan Nadin, Andrew M. James, Moritz Haneklaus, Susan Carpenter, Vincent P. Kelly, Michael P. Murphy, Louise K. Modis, Luke A. O’Neill

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Host metabolic reprogramming plays a role in functional responses against pathogens. Here, the authors characterise malonylated proteins in macrophages and show that malonylation of the glycolytic enzyme GAPDH impacts cytokine production by modulatin

Externí odkaz: https://doaj.org/article/4a15ae022f184e95bae97dad5d2e7a5a

Proximal Cysteines that Enhance Lysine N-Acetylation of Cytosolic Proteins in Mice Are Less Conserved in Longer-Living Species

Autor: Andrew M. James, Anthony C. Smith, Cassandra L. Smith, Alan J. Robinson, Michael P. Murphy

Publikováno v: Cell Reports, Vol 24, Iss 6, Pp 1445-1455 (2018)

Summary: Acetyl-coenzyme A (CoA) is an abundant metabolite that can also alter protein function through non-enzymatic N-acetylation of protein lysines. This N-acetylation is greatly enhanced in vitro if an adjacent cysteine undergoes initial S-acetyl

Externí odkaz: https://doaj.org/article/2968c8493b4446f0b0d11137e82e113f

Low production of mitochondrial reactive oxygen species after anoxia and reoxygenation in turtle hearts

Autor: Amanda Bundgaard, Anja V. Gruszczyk, Hiran A. Prag, Catherine Williams, Angela McIntyre, Ilan M. Ruhr, Andrew M. James, Gina L. J. Galli, Michael P. Murphy, Angela Fago

Publikováno v: Bundgaard, A, Gruszczyk, A V, Prag, H A, Williams, C, McIntyre, A, Ruhr, I M, James, A M, Galli, G L J, Murphy, M P & Fago, A 2023, ' Low production of mitochondrial reactive oxygen species after anoxia and reoxygenation in turtle hearts ', The Journal of Experimental Biology, vol. 226, no. 9 . https://doi.org/10.1242/jeb.245516
Bundgaard, A, Gruszczyk, A V, Prag, H A, Williams, C, Mcintyre, A, Ruhr, I M, James, A M, Galli, G L J, Murphy, M P & Fago, A 2023, ' Low production of mitochondrial reactive oxygen species after anoxia and reoxygenation in turtle hearts ', Journal of Experimental Biology . https://doi.org/10.1242/jeb.245516

Extremely anoxia-tolerant animals, such as freshwater turtles, survive anoxia and reoxygenation without sustaining tissue damage to their hearts. In contrast, for mammals, the ischemia–reperfusion (IR) injury that leads to tissue damage during a he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c0edc677451afec622f62c3bad67c6
https://pure.au.dk/portal/da/publications/low-production-of-mitochondrial-reactive-oxygen-species-after-anoxia-and-reoxygenation-in-turtle-hearts(217cb115-7d77-48fe-b655-49415632821a).html