Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Andrew M. Hogan"'
Autor:
Dustin T. Maydaniuk, Brielle Martens, Sarah Iqbal, Andrew M. Hogan, Neil Lorente Cobo, Anna Motnenko, Dang Truong, Sajani H. Liyanage, Mingdi Yan, Gerd Prehna, Silvia T. Cardona
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 2 (2024)
ABSTRACTDrug repurposing efforts led to the discovery of bactericidal activity in auranofin, a gold-containing drug used to treat rheumatoid arthritis. Auranofin kills Gram-positive bacteria by inhibiting thioredoxin reductase, an enzyme that scaveng
Externí odkaz:
https://doaj.org/article/1a6ae9ac46584d42a3eb3d1a16ac8dea
Autor:
Andrew M. Hogan, A. S. M. Zisanur Rahman, Anna Motnenko, Aakash Natarajan, Dustin T. Maydaniuk, Beltina León, Zayra Batun, Armando Palacios, Alejandra Bosch, Silvia T. Cardona
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract The cell envelope of Gram-negative bacteria belonging to the Burkholderia cepacia complex (Bcc) presents unique restrictions to antibiotic penetration. As a consequence, Bcc species are notorious for causing recalcitrant multidrug-resistant
Externí odkaz:
https://doaj.org/article/e75ea8b5840542578185833f4513f01c
Autor:
Chengyou Liu, Andrew M. Hogan, Hunter Sturm, Mohd Wasif Khan, Md. Mohaiminul Islam, A. S. M. Zisanur Rahman, Rebecca Davis, Silvia T. Cardona, Pingzhao Hu
Publikováno v:
Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-17 (2022)
Abstract Motivation Chemical–genetic interaction profiling is a genetic approach that quantifies the susceptibility of a set of mutants depleted in specific gene product(s) to a set of chemical compounds. With the recent advances in artificial inte
Externí odkaz:
https://doaj.org/article/5631e85a7daa4295b43b4e0a14be011b
Autor:
Dustin Maydaniuk, Bin Wu, Dang Truong, Sajani H. Liyanage, Andrew M. Hogan, Zhong Ling Yap, Mingdi Yan, Silvia T. Cardona
Publikováno v:
Antibiotics, Vol 10, Iss 12, p 1443 (2021)
Bacteria of the genus Burkholderia include pathogenic Burkholderia mallei, Burkholderia pseudomallei and the Burkholderia cepacia complex (Bcc). These Gram-negative pathogens have intrinsic drug resistance, which makes treatment of infections difficu
Externí odkaz:
https://doaj.org/article/0f95b848f6b74c7083c4a433dfc31cfb
Autor:
D. Craig Ayre, Ian C. Chute, Andrew P. Joy, David A. Barnett, Andrew M. Hogan, Marc P. Grüll, Lourdes Peña-Castillo, Andrew S. Lang, Stephen M. Lewis, Sherri L. Christian
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract The CD24 cell surface receptor promotes apoptosis in developing B cells, and we recently found that it induces B cells to release plasma membrane-derived, CD24-bearing microvesicles (MVs). Here we have performed a systematic characterization
Externí odkaz:
https://doaj.org/article/5fdc4db9bd1d46f7b03db8910ae362c7
Autor:
Jaroslav Nunvar, Andrew M. Hogan, Silvia Buroni, Svetlana Savina, Vadim Makarov, Silvia T. Cardona, Pavel Drevinek
Publikováno v:
Antibiotics, Vol 8, Iss 4, p 159 (2019)
Bacteria of the Burkholderia cepacia complex (Bcc) are associated with significant decline of lung functions in cystic fibrosis patients. Bcc infections are virtually impossible to eradicate due to their irresponsiveness to antibiotics. The 2-thiocya
Externí odkaz:
https://doaj.org/article/6052ffe320b6418ca17e1a26f7476200
Autor:
A. S. M. Zisanur Rahman, Chengyou Liu, Hunter Sturm, Andrew M. Hogan, Rebecca Davis, Pingzhao Hu, Silvia T. Cardona
Publikováno v:
PLoS computational biology. 18(10)
Screening for novel antibacterial compounds in small molecule libraries has a low success rate. We applied machine learning (ML)-based virtual screening for antibacterial activity and evaluated its predictive power by experimental validation. We firs
Autor:
Chengyou Liu, Andrew M. Hogan, Hunter Sturm, Mohd Wasif Khan, Md. Mohaiminul Islam, A. S. M. Zisanur Rahman, Rebecca Davis, Silvia T. Cardona, Pingzhao Hu
Publikováno v:
Journal of cheminformatics. 14(1)
Motivation Chemical–genetic interaction profiling is a genetic approach that quantifies the susceptibility of a set of mutants depleted in specific gene product(s) to a set of chemical compounds. With the recent advances in artificial intelligence,
Publikováno v:
Appl Environ Microbiol
A diverse genetic toolkit is critical for understanding bacterial physiology and genotype-phenotype relationships. Inducible promoter systems are an integral part of this toolkit. In Burkholderia and related species, the l-rhamnose-inducible promoter
Publikováno v:
ACS Synthetic Biology. 8:2372-2384
Genetic tools are critical to dissecting the mechanisms governing cellular processes, from fundamental physiology to pathogenesis. Members of the genus Burkholderia have potential for biotechnological applications but can also cause disease in humans