Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Andrew M. Donson"'
Autor:
Vladimir Amani, Kent A. Riemondy, Rui Fu, Andrea M. Griesinger, Enrique Grimaldo, Graziella Ribeiro De Sousa, Ahmed Gilani, Molly Hemenway, Nicholas K. Foreman, Andrew M. Donson, Nicholas Willard
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-15 (2023)
Abstract Plexiform neurofibroma (PN) is a leading cause of morbidity in children with the genetic condition Neurofibromatosis Type 1 (NF1), often disfiguring or threatening vital structures. During formation of PN, a complex tumor microenvironment (T
Externí odkaz:
https://doaj.org/article/fc4960bbcb234d0f88ab1397fa08f1c5
Autor:
Philipp Sievers, Martin Sill, Daniel Schrimpf, Zied Abdullaev, Andrew M. Donson, Jessica A. Lake, Dennis Friedel, David Scheie, Olli Tynninen, Tuomas Rauramaa, Kaisa L. Vepsäläinen, David Samuel, Rebecca Chapman, Richard G. Grundy, Kristian W. Pajtler, Arnault Tauziède-Espariat, Alice Métais, Pascale Varlet, Matija Snuderl, Thomas S. Jacques, Kenneth Aldape, David E. Reuss, Andrey Korshunov, Wolfgang Wick, Stefan M. Pfister, Andreas von Deimling, Felix Sahm, David T. W. Jones
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-8 (2023)
Abstract Pediatric neoplasms in the central nervous system (CNS) show extensive clinical and molecular heterogeneity and are fundamentally different from those occurring in adults. Molecular genetic testing contributes to accurate diagnosis and enabl
Externí odkaz:
https://doaj.org/article/9f54e4ebe7994704862580e7e4db4d5b
Autor:
Andrea M. Griesinger, Kent Riemondy, Nithyashri Eswaran, Andrew M. Donson, Nicholas Willard, Eric W. Prince, Simon M.L. Paine, Georgia Bowes, John Rheaume, Rebecca J. Chapman, Judith Ramage, Andrew Jackson, Richard G. Grundy, Nicholas K. Foreman, Timothy A. Ritzmann
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107585- (2023)
Summary: Ependymoma (EPN) is a devastating childhood brain tumor. Single-cell analyses have illustrated the cellular heterogeneity of EPN tumors, identifying multiple neoplastic cell states including a mesenchymal-differentiated subpopulation which c
Externí odkaz:
https://doaj.org/article/c21cc25b1c034ef5b5f324e282f7169c
Autor:
Maximilian Y. Deng, Dominik Sturm, Elke Pfaff, Martin Sill, Damian Stichel, Gnana Prakash Balasubramanian, Stephan Tippelt, Christof Kramm, Andrew M. Donson, Adam L. Green, Chris Jones, Jens Schittenhelm, Martin Ebinger, Martin U. Schuhmann, Barbara C. Jones, Cornelis M. van Tilburg, Andrea Wittmann, Andrey Golanov, Marina Ryzhova, Jonas Ecker, Till Milde, Olaf Witt, Felix Sahm, David Reuss, David Sumerauer, Josef Zamecnik, Andrey Korshunov, Andreas von Deimling, Stefan M. Pfister, David T. W. Jones
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies but their origin are still unclear. Here, the authors define the genomic, epigenetic and transcriptional landsca
Externí odkaz:
https://doaj.org/article/d294b00cf8014bf897f67d7d3d39f257
Autor:
Sarah A. Milgrom, MD, Jane Koo, MD, Nicholas Foreman, MD, Arthur K. Liu, MD PhD, Kristen Campbell, MS, Kathleen Dorris, MD, Adam L. Green, MD, Nathan Dahl, MD, Andrew M. Donson, BS, Rajeev Vibhakar, MD PhD, Jean M. Mulcahy Levy, MD
Publikováno v:
Advances in Radiation Oncology, Vol 7, Iss 4, Pp 100945- (2022)
Purpose: : The role of peri-transplant radiation therapy (RT) in children with primary brain tumors is unclear. We characterized our institutional practice patterns and patient outcomes. Methods and Materials: The cohort included all patients treated
Externí odkaz:
https://doaj.org/article/2d17f7f6783d4aba84ef951f5b4754a6
Autor:
Daniel Shiloh Malawsky, Seth J. Weir, Jennifer Karin Ocasio, Benjamin Babcock, Taylor Dismuke, Abigail H. Cleveland, Andrew M. Donson, Rajeev Vibhakar, Kirk Wilhelmsen, Timothy R. Gershon
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Malawsky, Weir et al. compare medulloblastomas that form in mice engineered to express SmoM2, a constitutively active component of the Sonic hedgehog signaling pathway, starting in either neural progenitor or stem cells. Medulloblastomas in the two m
Externí odkaz:
https://doaj.org/article/605864249f4542d69b3f957f5ac481cd
Autor:
Eric W. Prince, Ros Whelan, David M. Mirsky, Nicholas Stence, Susan Staulcup, Paul Klimo, Richard C. E. Anderson, Toba N. Niazi, Gerald Grant, Mark Souweidane, James M. Johnston, Eric M. Jackson, David D. Limbrick, Amy Smith, Annie Drapeau, Joshua J. Chern, Lindsay Kilburn, Kevin Ginn, Robert Naftel, Roy Dudley, Elizabeth Tyler-Kabara, George Jallo, Michael H. Handler, Kenneth Jones, Andrew M. Donson, Nicholas K. Foreman, Todd C. Hankinson
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Deep learning (DL) is a widely applied mathematical modeling technique. Classically, DL models utilize large volumes of training data, which are not available in many healthcare contexts. For patients with brain tumors, non-invasive diagnosi
Externí odkaz:
https://doaj.org/article/48a196a679684d488c084efeeb434cda
Autor:
Austin E. Gillen, Kent A. Riemondy, Vladimir Amani, Andrea M. Griesinger, Ahmed Gilani, Sujatha Venkataraman, Krishna Madhavan, Eric Prince, Bridget Sanford, Todd C. Hankinson, Michael H. Handler, Rajeev Vibhakar, Ken L. Jones, Siddhartha Mitra, Jay R. Hesselberth, Nicholas K. Foreman, Andrew M. Donson
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 108023- (2020)
Summary: Ependymoma (EPN) is a brain tumor commonly presenting in childhood that remains fatal in most children. Intra-tumoral cellular heterogeneity in bulk-tumor samples significantly confounds our understanding of EPN biology, impeding development
Externí odkaz:
https://doaj.org/article/86aaa43b961a406abbb08113d63ce8d6
Autor:
Sydney Grob, David M. Mirsky, Andrew M. Donson, Nathan Dahl, Nicholas K. Foreman, Lindsey M. Hoffman, Todd C. Hankinson, Jean M. Mulcahy Levy
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Adamantinomatous craniopharyngioma (ACP) makes up between 6 and 8% of pediatric brain tumors and is the most common pediatric tumor arising in the sellar/suprasellar region of the brain. The 10-year survival for patients diagnosed with craniopharyngi
Externí odkaz:
https://doaj.org/article/86d1b3e873da43a9b5d7d931891eae4b
Autor:
Andrew M Donson, Kelsey C Bertrand, Kent A Riemondy, Dexiang Gao, Yonghua Zhuang, Bridget Sanford, Gregory A Norris, Rebecca J Chapman, Rui Fu, Nicholas Willard, Andrea M Griesinger, Graziella Ribeiro de Sousa, Vladimir Amani, Enrique Grimaldo, Todd C Hankinson, Ffyona Booker, Martin Sill, Richard G Grundy, Kristian W Pajtler, David W Ellison, Nicholas K Foreman, Timothy A Ritzmann
Publikováno v:
Neuro-Oncology.
Background Ependymoma (EPN) posterior fossa group A (PFA) has the highest rate of recurrence and the worst prognosis of all EPN molecular groups. At relapse, it is typically incurable even with re-resection and re-irradiation. The biology of recurren