Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Andrew M. Swensen"'
Autor:
Yao Liang Wong, Lauren LeBon, Ana M Basso, Kathy L Kohlhaas, Arthur L Nikkel, Holly M Robb, Diana L Donnelly-Roberts, Janani Prakash, Andrew M Swensen, Nimrod D Rubinstein, Swathi Krishnan, Fiona E McAllister, Nicole V Haste, Jonathon J O'Brien, Margaret Roy, Andrea Ireland, Jennifer M Frost, Lei Shi, Stephan Riedmaier, Kathleen Martin, Michael J Dart, Carmela Sidrauski
Publikováno v:
eLife, Vol 8 (2019)
The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2
Externí odkaz:
https://doaj.org/article/7ff3f238f99040afb97c2dc3b9419d6e
Autor:
Maarten Gees, Sara Musch, Steven Van der Plas, Anne-Sophie Wesse, Ann Vandevelde, Katleen Verdonck, Oscar Mammoliti, Tzyh-Chang Hwang, Kathleen Sonck, Pieter Stouten, Andrew M. Swensen, Mia Jans, Jan Van der Schueren, Luc Nelles, Martin Andrews, Katja Conrath
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
There is still a high unmet need for the treatment of most patients with cystic fibrosis (CF). The identification and development of new Cystic Fibrosis Transmembrane conductance Regulator (CFTR) modulators is necessary to achieve higher clinical ben
Externí odkaz:
https://doaj.org/article/99852fe337bc4182a943b73d103f71f5
Autor:
C. Tse, Ying Jia, X. Wang, Liu Bo, Douglas M. Cyr, Torben R. Neelands, Wenqing Gao, Xenia B. Searle, Ashvani K. Singh, Timothy A. Vortherms, Hong Y. Ren, Andrew M. Swensen, Corina Balut, Arlene M. Manelli, Sara Alani, Philip R. Kym, K. Conrath, Tzyh Chang Hwang, Yihong Fan
Publikováno v:
J Pharmacol Exp Ther
Cystic fibrosis (CF) is the most common monogenic autosomal recessive disease in Caucasians caused by pathogenic mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene (CFTR). Significant small molecule therapeutic advances
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a61d3189fed304b0edc5967e5538659
https://doi.org/10.1124/jpet.119.261800
https://doi.org/10.1124/jpet.119.261800
Autor:
Wenqing Gao, Robert J. Altenbach, Gang Zhao, John R. Koenig, Greszler Stephen N, Searle Xenia B, Gregory A. Gfesser, Hong Yong, Corina Balut, Marc J. C. Scanio, Yihong Fan, Michael R. Schrimpf, Philip R. Kym, Timothy A. Vortherms, Andrew M. Swensen, Bo Liu, Arlene M. Manelli, Ying Jia, Xueqing Wang, Chris Tse, Andrew Bogdan, Ashvani K. Singh
Publikováno v:
ACS Med Chem Lett
[Image: see text] Cystic fibrosis (CF) is a genetic disorder that affects multiple tissues and organs. CF is caused by mutations in the CFTR gene, resulting in insufficient or impaired cystic fibrosis transmembrane conductance regulator (CFTR) protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418648a24d9417696c73d206f53310b2
https://doi.org/10.1021/acsmedchemlett.9b00377
https://doi.org/10.1021/acsmedchemlett.9b00377
Autor:
Marc J C, Scanio, Xenia B, Searle, Bo, Liu, John R, Koenig, Robert J, Altenbach, Gregory A, Gfesser, Andrew, Bogdan, Stephen, Greszler, Gang, Zhao, Ashvani, Singh, Yihong, Fan, Andrew M, Swensen, Timothy, Vortherms, Arlene, Manelli, Corina, Balut, Wenqing, Gao, Hong, Yong, Michael, Schrimpf, Chris, Tse, Philip, Kym, Xueqing, Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 72:128843
Cystic fibrosis (CF) is an autosomal recessive disease resulting from mutations on both copies of the CFTR gene. Phenylalanine deletion at position 508 of the CFTR protein (F508del-CFTR) is the most frequent mutation in CF patients. Currently, the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a2a884faa7901f5e486831d30b03cd
https://doi.org/10.1016/j.bmcl.2022.128843
https://doi.org/10.1016/j.bmcl.2022.128843
Autor:
A. M. Manelli, Y. Jia, Philip R. Kym, X. Wang, Timothy A. Vortherms, S. Alani, Wenqing Gao, C. Balut, Ashvani K. Singh, Tzyh Chang Hwang, Douglas M. Cyr, H. Y. Ren, Andrew M. Swensen, Y. Fan, Torben R. Neelands, K. Conrath, C. Tse, Xenia B. Searle, Liu Bo
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 374(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f06a07779c4c9652d155ca898680f4
https://pubmed.ncbi.nlm.nih.gov/31732698
https://pubmed.ncbi.nlm.nih.gov/31732698
Autor:
Searle Xenia B, Wenqing Gao, Andrew M. Swensen, Timothy A. Vortherms, Hong Yong, Clinton Yeung, Corina Balut, Philip R. Kym, Yihong Fan, Ashvani K. Singh, Greszler Stephen N, Kelly E. Desino, Andrew Bogdan, Ying Jia, Chris Tse, Xueqing Wang, Bo Liu
Publikováno v:
Journal of Medicinal Chemistry. 61:1436-1449
Cystic fibrosis (CF) is a multiorgan disease of the lungs, sinuses, pancreas, and gastrointestinal tract that is caused by a dysfunction or deficiency of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, an epithelial anion chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7451d4d615499d205ff8e0f34d896f9a
https://doi.org/10.1021/acs.jmedchem.7b01339
https://doi.org/10.1021/acs.jmedchem.7b01339
Autor:
Nicole V Haste, Diana Donnelly-Roberts, Swathi Krishnan, Lauren LeBon, Jennifer M. Frost, Fiona E. McAllister, Andrea T. Ireland, Yao Liang Wong, Carmela Sidrauski, Stephan Riedmaier, Michael J. Dart, Kathy L. Kohlhaas, Lei Shi, Nimrod D. Rubinstein, Ana M. Basso, Janani Prakash, Kathleen A. Martin, Andrew M. Swensen, Arthur L. Nikkel, Jonathon J. O’Brien, Margaret Ann Roy, Holly M. Robb
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9990114b53b75c88cb58914a496683c
https://doi.org/10.7554/elife.42940
https://doi.org/10.7554/elife.42940
Autor:
Shawn P. Walsh, Lee-Yuh Pai, Yuping Zhu, John P. Felix, Caryn Hampton, Xiaoyan Zhou, Melba Hernandez, Brande Thomas-Fowlkes, Richard M. Brochu, Nardos Teumelsan, Gregory J. Kaczorowski, Emma R. Parmee, Maria L. Garcia, Alexander Pasternak, Jinlong Jiang, Sookhee Ha, Sophie Roy, Kathleen A. Sullivan, Haifeng Tang, Lihu Yang, Karen Owens, Reynalda K. de Jesus, Xin Gu, Birgit T. Priest, Barbara Pio, Fa-Xiang Ding, Andrew M. Swensen, Magdalena Alonso-Galicia, Aurash Shahripour, Juliann Ehrhart, Timothy Bailey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5695-5702
Following the discovery of small molecule acyl piperazine ROMK inhibitors, the acyl octahydropyrazino[2,1-c][1,4]oxazine series was identified. This series displays improved ROMK/hERG selectivity, and as a consequence, the resulting ROMK inhibitors d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5ba115f699ab80f9a1176691245bcc
https://doi.org/10.1016/j.bmcl.2016.10.064
https://doi.org/10.1016/j.bmcl.2016.10.064
Autor:
Michael J. Forrest, John P. Felix, Lee-Yuh Pai, Melba Hernandez, Yuping Zhu, Aaron Corona, Joseph M. Metzger, Gregory J. Kaczorowski, Nardos Teumelsan, Lihu Yang, Karen Owens, Timothy Bailey, Caryn Hampton, Vincent Tong, Alexander Pasternak, Brande Thomas-Fowlkes, Shawn P. Walsh, Emma R. Parmee, Haifeng Tang, Richard M. Brochu, Maria L. Garcia, Xiaoyan Zhou, Magdalena Alonso-Galicia, Sophie Roy, Birgit T. Priest, Andrew M. Swensen, Aurash Shahripour
Publikováno v:
ACS Medicinal Chemistry Letters. 7:697-701
ROMK, the renal outer medullary potassium channel, is involved in potassium recycling at the thick ascending loop of Henle and potassium secretion at the cortical collecting duct in the kidney nephron. Because of this dual site of action, selective i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415e7bac5379921d8eb6098d8804f901
https://doi.org/10.1021/acsmedchemlett.6b00122
https://doi.org/10.1021/acsmedchemlett.6b00122