Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Andrew M Shaw"'
Autor:
Atul Kumar, Jevgenia Tamjar, Andrew D Waddell, Helen I Woodroof, Olawale G Raimi, Andrew M Shaw, Mark Peggie, Miratul MK Muqit, Daan MF van Aalten
Publikováno v:
eLife, Vol 6 (2017)
Mutations in the human kinase PINK1 (hPINK1) are associated with autosomal recessive early-onset Parkinson's disease (PD). hPINK1 activates Parkin E3 ligase activity, involving phosphorylation of ubiquitin and the Parkin ubiquitin-like (Ubl) domain v
Externí odkaz:
https://doaj.org/article/20fff1131a3e4ec08eaeefa1982c53ca
Autor:
Andrew D. Waddell, Hina Ojha, Shalini Agarwal, Christopher J. Clarke, Ana Terriente-Felix, Houjiang Zhou, Poonam Kakade, Axel Knebel, Andrew M. Shaw, Robert Gourlay, Joby Varghese, Renata F. Soares, Rachel Toth, Thomas Macartney, Patrick A. Eyers, Nick Morrice, Richard Bayliss, Alexander J. Whitworth, Claire E. Eyers, Miratul M. K. Muqit
Loss-of-function mutations in the human PINK1 kinase (hPINK1) are causative of early-onset Parkinson’s disease (PD). Activation of hPINK1 induces phosphorylated ubiquitin to initiate removal of damaged mitochondria by autophagy. Previously we solve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e00472b151d1285b844ca753507a62
https://doi.org/10.1101/2023.03.31.534916
https://doi.org/10.1101/2023.03.31.534916
Autor:
Zhe Song, Daniel R. Moore, Nathan Hodson, Carl Ward, Jessica R. Dent, Mary F. O’Leary, Andrew M. Shaw, D. Lee Hamilton, Sovan Sarkar, Yann-Gaël Gangloff, Troy A. Hornberger, Lawrence L. Spriet, George J. Heigenhauser, Andrew Philp
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The mechanistic target of rapamycin (mTOR) is a central mediator of protein synthesis in skeletal muscle. We utilized immunofluorescence approaches to study mTOR cellular distribution and protein-protein co-localisation in human skeletal mus
Externí odkaz:
https://doaj.org/article/71453322f31c4042b79fba8f35f34ad7
Autor:
Philip H. James-Pemberton, Shivali Kohli, Aaron C. Westlake, Alex Antill, Jade Hunt, Rouslan V. Olkhov, Andrew M. Shaw
A fully quantitative comparative analysis has been performed on the differential antibody binding to a spectrum of Spike proteins to the SARS-CoV-2 variants Wuhan, Alpha, Beta, Gamma, Delta and Omicron BA.1, BA.1, BA.4, BA.5, BA.2.75 and BA.2.12.1. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9f7ec7007b1f16ac3981c58066a316b
https://doi.org/10.1101/2023.01.11.23284431
https://doi.org/10.1101/2023.01.11.23284431
Autor:
Andrew M. Shaw, Payam A. Gammage
Publikováno v:
Methods in Molecular Biology ISBN: 9781071629215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5c38e9b3c55f4085ac25e4a688d3350
https://doi.org/10.1007/978-1-0716-2922-2_3
https://doi.org/10.1007/978-1-0716-2922-2_3
Autor:
Philip H. James-Pemberton, Shivali Kohli, Aaron C. Westlake, Alex Antill, Rouslan V. Olkhov, Andrew M. Shaw
In summer of 2022, a cohort of 28 staff members were recruited from a UK primary school setting. The prevalent variants at the time were Omicron BA.1.159, BA.4/5 and BA.2: 61% of the cohort reported a lateral flow confirmed positive test for SARS-CoV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8c5b08031de3239fe51e89afd562ef2
https://doi.org/10.1101/2022.12.01.22282932
https://doi.org/10.1101/2022.12.01.22282932
Autor:
Philip H. James-Pemberton, Shivali Kohli, Jordan Twynham, Aaron C. Westlake, Alex Antill, Jade Hunt, Rouslan V. Olkhov, Andrew M. Shaw
A fully quantitative comparative analysis of the differential binding to spike variant proteins to SARS-CoV-2 has been performed for the variants: Wuhan (ancestral strain), Alpha, Beta, Gamma, Delta and Omicron BA.1. Evolution of immunity through fiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff9a50c947aa76f97c39a14d8fe71b54
https://doi.org/10.1101/2022.09.23.22280271
https://doi.org/10.1101/2022.09.23.22280271
Autor:
Philip H. James-Pemberton, Mark W. Helliwell, Rouslan V. Olkhov, Shivali Kohli, Aaron C. Westlake, Benjamin M. Farrar, Ben J. Sutton, Nicholas D. Ager, Andrew M. Shaw
The SARS-CoV-2 Omicron variant (BA.1) has 25 unique mutations to the Spike glycoprotein, suggesting the efficacy of current vaccines against the new variant may be seriously degraded. A fully quantitative antibody binding study was performed for Spik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64f6b154eaac4316ae1f9c64540e36e9
https://doi.org/10.1101/2022.07.12.22277539
https://doi.org/10.1101/2022.07.12.22277539
Autor:
Philip H. James-Pemberton, Mark W. Helliwell, Rouslan V. Olkhov, Shivali Kohli, Aaron C. Westlake, Benjamin M. Farrar, Andrew M. Shaw
Humanised recombinant antibodies specific to the SARS-CoV-2 Spike protein were calibrated against the NISTmAb standard human antibody to produce a fully quantitative antibody assay. The assay allows comparative studies between patient cohorts to be p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f2b95ab935964f2148c621296843e07
https://doi.org/10.1101/2022.07.12.22277533
https://doi.org/10.1101/2022.07.12.22277533
Autor:
Miratul M. K. Muqit, Richard Bayliss, Thomas Macartney, James R. Ault, Ewelina Krysztofinska, Olawale G. Raimi, Poonam S. Kakade, Andrew M. Shaw, Atul Kumar, Kathrin Brockmann, Andrew D. Waddell, Sophie Burel, Mohd Ahanger, Hina Ojha, Julia C. Fitzgerald
Publikováno v:
Open Biology, Vol 12, Iss 1 (2022)
Open biology 12(1), 210264 (2022). doi:10.1098/rsob.210264
Open Biology
Open biology 12(1), 210264 (2022). doi:10.1098/rsob.210264
Open Biology
Human autosomal recessive mutations in the PINK1 gene are causal for Parkinson’s disease (PD). PINK1 encodes a mitochondrial localised protein kinase that is a master-regulator of mitochondrial quality control pathways. Structural studies to date h