Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Andrew M Scharenberg"'
Autor:
Byoung Y Ryu, Kathryn R Michels, Alyssa Sheih, Susana A Hernandez, Alissa H Brandes, Don Parrilla, Blythe Irwin, Anai M Perez, Hung-An Ting, Christopher J Nicolai, Timothy Gervascio, Seungjin Shin, Mark D Pankau, Mason Muhonen, Jessica Freeman, Sarah Gould, Rich Getto, Ryan P Larson, Andrew M Scharenberg, Alessandra M Sullivan, Shon Green
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 3 (2023)
Background Chimeric antigen receptor (CAR) T-cell therapies have demonstrated transformational outcomes in the treatment of B-cell malignancies, but their widespread use is hindered by technical and logistical challenges associated with ex vivo cell
Externí odkaz:
https://doaj.org/article/a89752227f79448587a521f6cc52e072
Publikováno v:
PLoS Biology, Vol 16, Iss 3, p e1002621 (2018)
[This corrects the article DOI: 10.1371/journal.pbio.1000428.].
Externí odkaz:
https://doaj.org/article/13554c63aa6444c59b7aaeb7f0390951
Autor:
Alexandra E Grier, Stephen Burleigh, Jaya Sahni, Courtnee A Clough, Victoire Cardot, Dongwook C Choe, Michelle C Krutein, David J Rawlings, Michael C Jensen, Andrew M Scharenberg, Kyle Jacoby
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Increasing demand for large-scale synthesis of in vitro transcribed (IVT) mRNA is being driven by the increasing use of mRNA for transient gene expression in cell engineering and therapeutic applications. An important determinant of IVT mRNA potency
Externí odkaz:
https://doaj.org/article/0765478c45c24feb9f2d7d51e87d648f
Autor:
Martine Aubert, Nicole M Boyle, Daniel Stone, Laurence Stensland, Meei-Li Huang, Amalia S Magaret, Roman Galetto, David J Rawlings, Andrew M Scharenberg, Keith R Jerome
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)
Following acute infection, herpes simplex virus (HSV) establishes latency in sensory neurons, from which it can reactivate and cause recurrent disease. Available antiviral therapies do not affect latent viral genomes; therefore, they do not prevent r
Externí odkaz:
https://doaj.org/article/75315e5de9ce43a89af760b711a5b7fd
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44452 (2012)
Recent studies have shown that the vertebrate magnesium transporters Solute carrier family 41, members 1 and 2 (SLC41A1, SLC41A2) and Magnesium transporter subtype 1 (MagT1) can endow vertebrate B-cells lacking the ion-channel kinase Transient recept
Externí odkaz:
https://doaj.org/article/9917a2e54d54470a8cd303f222d544f6
Autor:
Martine Aubert, Byoung Y Ryu, Lindsey Banks, David J Rawlings, Andrew M Scharenberg, Keith R Jerome
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16825 (2011)
Current antiviral therapy does not cure HIV-infected individuals because the virus establishes lifelong latent infection within long-lived memory T cells as integrated HIV proviral DNA. Here, we report a new therapeutic approach that aims to cure cel
Externí odkaz:
https://doaj.org/article/d116fef6093248cf93b87e56d25ff3c4
Publikováno v:
PLoS Biology, Vol 8, Iss 7, p e1000428 (2010)
Genetic variation at immunoglobulin (Ig) gene variable regions in B-cells is created through a multi-step process involving deamination of cytosine bases by activation-induced cytidine deaminase (AID) and their subsequent mutagenic repair. To protect
Externí odkaz:
https://doaj.org/article/a2e5aa36441c454582c1ba7d63418a5f
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6339 (2009)
Poly adenosine diphosphate-ribose polymerase-1 (PARP-1) is a multifunctional enzyme that is involved in two major cellular responses to oxidative and nitrosative (O/N) stress: detection and response to DNA damage via formation of protein-bound poly a
Externí odkaz:
https://doaj.org/article/0538f7f3666340658c92f9b335d5230c
Autor:
Ben Buelow, Andrew M Scharenberg
Publikováno v:
PLoS ONE, Vol 3, Iss 9, p e3264 (2008)
Conditional gene targeting using the Cre-loxp system is a well established technique in numerous in vitro and in vivo systems. Ligand regulated forms of Cre have been increasingly used in these applications in order to gain temporal and spatial contr
Externí odkaz:
https://doaj.org/article/aaa5a2e6090e49d988e165e04f050513
Autor:
Olivier Humbert, Frieda Chan, Yogendra S. Rajawat, Troy R. Torgerson, Christopher R. Burtner, Nicholas W. Hubbard, Daniel Humphrys, Zachary K. Norgaard, Patricia O'Donnell, Jennifer E. Adair, Grant D. Trobridge, Andrew M. Scharenberg, Peter J. Felsburg, David J. Rawlings, Hans-Peter Kiem
Publikováno v:
Blood Advances, Vol 2, Iss 9, Pp 987-999 (2018)
Abstract: Hematopoietic stem-cell gene therapy is a promising treatment of X-linked severe combined immunodeficiency disease (SCID-X1), but currently, it requires recipient conditioning, extensive cell manipulation, and sophisticated facilities. With
Externí odkaz:
https://doaj.org/article/3e55cf5967d441c1ad4a379d1df78d1a