Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Andrew M Petros"'
Autor:
Joy Loh, Qiulong Huang, Andrew M Petros, David Nettesheim, Linda F van Dyk, Lucia Labrada, Samuel H Speck, Beth Levine, Edward T Olejniczak, Herbert W Virgin
Publikováno v:
PLoS Pathogens, Vol 1, Iss 1, p e10 (2005)
Antiapoptotic Bcl-2 family proteins inhibit apoptosis in cultured cells by binding BH3 domains of proapoptotic Bcl-2 family members via a hydrophobic BH3 binding groove on the protein surface. We investigated the physiological importance of the BH3 b
Externí odkaz:
https://doaj.org/article/ab77daa81cbe4a85ab9e3b2219e4f498
Autor:
Eric R. Goedken, Maria A. Argiriadi, Justin D. Dietrich, Andrew M. Petros, Navasona Krishnan, Sanjay C. Panchal, Wei Qiu, Haihong Wu, Haizhong Zhu, Ashley M. Adams, Pierre M. Bodelle, Lucas Goguen, Paul L. Richardson, Peter F. Slivka, Myron Srikumaran, Anup K. Upadhyay, Bainan Wu, Russell A. Judge, Anil Vasudevan, Sujatha M. Gopalakrishnan, Philip B. Cox, Vincent S. Stoll, Chaohong Sun
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Anti-IL17A therapies have proven effective for numerous inflammatory diseases including psoriasis, axial spondylitis and psoriatic arthritis. Modulating and/or antagonizing protein–protein interactions of IL17A cytokine binding to its cell
Externí odkaz:
https://doaj.org/article/73a129f16e244becaaa09ce714e81a66
Autor:
Kathy Sarris, Philip J. Hajduk, Ihle David C, Diana L. Donnelly-Roberts, Arthur Gomtsyan, Christian Goess, David B. Duignan, Danying Song, Chaohong Sun, Andrea Mcclure, Adrian D. Hobson, Robert H. Stoffel, Anil Vasudevan, John A. Mankovich, Sanjay C. Panchal, A. Chris Krueger, Steven L. Swann, Kenneth M. Comess, Andrew M. Petros, Wilson Noel S, Jill M. Wetter, Paul G. Richardson, Kenton L. Longenecker, Paul M. Jung, Vincent S. Stoll, Amanda W. Dombrowski, Suzanne Mathieu, Justin D. Dietrich, Philip B. Cox
Publikováno v:
Journal of Medicinal Chemistry. 64:417-429
Tumor necrosis factor α (TNFα) is a soluble cytokine that is directly involved in systemic inflammation through the regulation of the intracellular NF-κB and MAPK signaling pathways. The development of biologic drugs that inhibit TNFα has led to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72dbe3ede703ddd1435f27709b6c8281
https://doi.org/10.1021/acs.jmedchem.0c01280
https://doi.org/10.1021/acs.jmedchem.0c01280
Autor:
Anup K. Upadhyay, Andrew M. Petros, Chaohong Sun, Andrew T. Namanja, Steven R. Van Doren, Jia Xu, Qi Sun, Haihong Wu
Publikováno v:
Journal of Biomolecular NMR. 73:675-685
Protein-based NMR spectroscopy has proven to be a very robust method for finding fragment leads to protein targets. However, one limitation of protein-based NMR is that the data acquisition and analysis can be time consuming. In order to streamline t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce3b37c313294ed47064f866eb097f0
https://doi.org/10.1007/s10858-019-00279-9
https://doi.org/10.1007/s10858-019-00279-9
Autor:
Jianwen Xu, Siew Leong Chan, Czeslaw Radziejewski, Chaohong Sun, Andrew Namanja, Peter M. Ihnat, Chelsea Son, Andrew M. Petros
Publikováno v:
Journal of pharmaceutical sciences. 110(12)
The purpose of this investigation was to highlight the utility of nuclear magnetic resonance (NMR) as a multi-attribute method for the characterization of therapeutic antibodies. In this case study, we compared results from isothermal chemical denatu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c98ef5d42cad36b3cd89c8bd43d52b0
https://pubmed.ncbi.nlm.nih.gov/34506864
https://pubmed.ncbi.nlm.nih.gov/34506864
Autor:
Anup K. Upadhyay, Ron Pithawalla, Rodger F. Henry, Russell A. Judge, Chaohong Sun, Justin A. Simanis, Leiming Li, Violeta L. Marin, Andrew M. Petros, Pierre M. Bodelle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1708-1713
The tandem TUDOR domains present in the non-catalytic C-terminal half of the KDM4A, 4B and 4C enzymes play important roles in regulating their chromatin localizations and substrate specificities. They achieve this regulatory role by binding to differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb7dcb63ded0bdffc7ddcc0ad4e291a
https://doi.org/10.1016/j.bmcl.2018.04.050
https://doi.org/10.1016/j.bmcl.2018.04.050
Autor:
Andrew M. Petros, Alla Korepanova, Clarissa G. Jakob, Wei Qiu, Sanjay C. Panchal, Jie Wang, Justin D. Dietrich, Jason T. Brewer, Frauke Pohlki, Andreas Kling, Kyle Wilcox, Viktor Lakics, Lamiaa Bahnassawy, Peter Reinhardt, Sarathy Karunan Partha, Pierre M. Bodelle, Marc Lake, Erik I. Charych, Vincent S. Stoll, Chaohong Sun, Eric G. Mohler
Publikováno v:
Journal of medicinal chemistry. 62(8)
Apolipoprotein E is a 299-residue lipid carrier protein produced in both the liver and the brain. The protein has three major isoforms denoted apoE2, apoE3, and apoE4 which differ at positions 112 and 158 and which occur at different frequencies in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353512c6397009fb6a0711d678d2c1aa
https://pubmed.ncbi.nlm.nih.gov/30933499
https://pubmed.ncbi.nlm.nih.gov/30933499
Autor:
Violeta L. Marin, Wenyu Yu, William N. Pappano, Peter Brown, Fengling Li, Masoud Vedadi, Charles W. Hutchins, Andrew M. Petros, Maricel Torrent, Chaohong Sun, Haizhong Zhu, Anup K. Upadhyay, Pierre M. Bodelle, Russell A. Judge
Publikováno v:
ACS Medicinal Chemistry Letters. 7:1102-1106
SETD8 is a histone H4–K20 methyltransferase that plays an essential role in the maintenance of genomic integrity during mitosis and in DNA damage repair, making it an intriguing target for cancer research. While some small molecule inhibitors for S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768047a77724c668da15da1e2b409585
https://doi.org/10.1021/acsmedchemlett.6b00303
https://doi.org/10.1021/acsmedchemlett.6b00303
Autor:
Marc R. Lake, Alla Korepanova, Andrew M. Petros, Richard F. Clark, Steve D. Pratt, Sanjay C. Panchal, Diana Raich, Sujatha M. Gopalakrishnan, Chaohong Sun, Kenton L. Longenecker
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(3)
NAMPT expression is elevated in many cancers, making this protein a potential target for anticancer therapy. We have carried out both NMR based and TR-FRET based fragment screens against human NAMPT and identified six novel binders with a range of po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384d35532a2c046abcae0037b713c247
https://pubmed.ncbi.nlm.nih.gov/29287958
https://pubmed.ncbi.nlm.nih.gov/29287958
Autor:
Keith F. McDaniel, Carol K. Wada, Terrance J. Magoc, Warren M. Kati, Dachun Liu, Chaohong Sun, Lisa A. Hasvold, Le Wang, Robert A. Mantei, John K. Pratt, Yu Shen, Michael D. Wendt, T. Matthew Hansen, Charles W. Hutchins, Andrew M. Petros, Robin R. Frey, Denise Wilcox, Xiaoyu Lin, Chang H. Park, Rongqi Wang, Xiaoli Huang, Robert D. Hubbard, Peter Kovar, William J. McClellan, James H. Holms, George S. Sheppard, Leiming Li, Ganesh Rajaraman, Daniel H. Albert, Sanjay C. Panchal, Scott E. Warder, Steven D. Fidanze, Todd N. Soltwedel, Steven W. Elmore
Publikováno v:
Journal of medicinal chemistry. 60(9)
Members of the BET family of bromodomain containing proteins have been identified as potential targets for blocking proliferation in a variety of cancer cell lines. A two-dimensional NMR fragment screen for binders to the bromodomains of BRD4 identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e1929bf0879c380bd4f0cda1201778
https://pubmed.ncbi.nlm.nih.gov/28368119
https://pubmed.ncbi.nlm.nih.gov/28368119