Zobrazeno 1 - 10
of 343
pro vyhledávání: '"Andrew M Lew"'
Autor:
Mitra Ashayeripanah, Javier Vega-Ramos, Daniel Fernandez-Ruiz, Shirin Valikhani, Aaron T.L. Lun, Jason T. White, Louise J. Young, Atefeh Yaftiyan, Yifan Zhan, Linda Wakim, Irina Caminschi, Mireille H. Lahoud, Andrew M. Lew, Ken Shortman, Gordon K. Smyth, William R. Heath, Justine D. Mintern, Antoine Roquilly, Jose A. Villadangos
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113754- (2024)
Summary: Blood-borne pathogens can cause systemic inflammatory response syndrome (SIRS) followed by protracted, potentially lethal immunosuppression. The mechanisms responsible for impaired immunity post-SIRS remain unclear. We show that SIRS trigger
Externí odkaz:
https://doaj.org/article/531a91054c1e4bb68aeda10b35050804
Autor:
Timothy Patton, Zhe Zhao, Xin Yi Lim, Eleanor Eddy, Huimeng Wang, Adam G. Nelson, Bronte Ennis, Sidonia B. G. Eckle, Michael N. T. Souter, Troi J. Pediongco, Hui-Fern Koay, Jian-Guo Zhang, Tirta M. Djajawi, Cynthia Louis, Najoua Lalaoui, Nicolas Jacquelot, Andrew M. Lew, Daniel G. Pellicci, James McCluskey, Yifan Zhan, Zhenjun Chen, Kate E. Lawlor, Alexandra J. Corbett
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-11 (2023)
Abstract Cell death mechanisms in T lymphocytes vary according to their developmental stage, cell subset and activation status. The cell death control mechanisms of mucosal-associated invariant T (MAIT) cells, a specialized T cell population, are lar
Externí odkaz:
https://doaj.org/article/32f7d36c0eb7467ba12335d55c4d8b1e
Autor:
Wayne J. Hawthorne, Evelyn J. Salvaris, Yi Vee Chew, Heather Burns, Joanne Hawkes, Helen Barlow, Min Hu, Andrew M. Lew, Mark B. Nottle, Philip J. O’Connell, Peter J. Cowan
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Xenotransplantation using porcine donors is rapidly approaching clinical applicability as an alternative therapy for treatment of many end-stage diseases including type 1 diabetes. Porcine neonatal islet cell clusters (NICC) have normalised blood sug
Externí odkaz:
https://doaj.org/article/8c52f60777f04c9ab509a31950cc5a1a
Autor:
Xiaoyan Liu, Zhe Li, Shuai Liu, Jing Sun, Zhanghua Chen, Min Jiang, Qingling Zhang, Yinghua Wei, Xin Wang, Yi-You Huang, Yinyi Shi, Yanhui Xu, Huifang Xian, Fan Bai, Changxing Ou, Bei Xiong, Andrew M. Lew, Jun Cui, Rongli Fang, Hui Huang, Jincun Zhao, Xuechuan Hong, Yuxia Zhang, Fuling Zhou, Hai-Bin Luo
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 7, Pp 1205-1215 (2020)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause acute respiratory distress syndrome, hypercoagulability, hypertension, and multiorgan dysfunction. Effective antivirals with safe clinical profile are urgently needed to
Externí odkaz:
https://doaj.org/article/961d6c2809cb41e197a7c2eddff405db
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The correlation of infections with vascular autoinflammatory diseases such as vasculitis and atherosclerosis has been long recognized, and progressive inflammation with the formation of tertiary lymphoid organs in arterial adventitia intensively stud
Externí odkaz:
https://doaj.org/article/4ec2f09a97b546e586768eaa33e4149f
Autor:
Shengbo Zhang, Jai Rautela, Naiara G. Bediaga, Tatiana B. Kolesnik, Yue You, Junli Nie, Laura F. Dagley, Justin Bedo, Hanqing Wang, Li Sun, Robyn Sutherland, Elliot Surgenor, Nadia Iannarella, Rhys Allan, Fernando Souza-Fonseca-Guimaraes, Yi Xie, Qike Wang, Yuxia Zhang, Yuekang Xu, Stephen L. Nutt, Andrew M. Lew, Nicholas D. Huntington, Sandra E. Nicholson, Michaël Chopin, Yifan Zhan
Publikováno v:
Cellular & Molecular Immunology. 20:65-79
The cytokine granulocyte-macrophage-colony stimulating factor (GM-CSF) possesses the capacity to differentiate monocytes into macrophages (MØs) with opposing functions, namely, proinflammatory M1-like MØs and immunosuppressive M2-like MØs. Despite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1d200d90c19deb41c9a373bf5075a6
https://doi.org/10.1038/s41423-022-00957-z
https://doi.org/10.1038/s41423-022-00957-z
Autor:
Mark B. Nottle, Evelyn J. Salvaris, Nella Fisicaro, Stephen McIlfatrick, Ivan Vassiliev, Wayne J. Hawthorne, Philip J. O’Connell, Jamie L. Brady, Andrew M. Lew, Peter J. Cowan
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Xenotransplantation from pigs has been advocated as a solution to the perennial shortage of donated human organs and tissues. CRISPR/Cas9 has facilitated the silencing of genes in donor pigs that contribute to xenograft rejection. However, t
Externí odkaz:
https://doaj.org/article/13fe765c6d834f9facf6f7bbc3879a6c
Autor:
Robyn M. Sutherland, Sarah L. Londrigan, Jamie L. Brady, Emma M. Carrington, Julia M. Marchingo, Susanne Heinzel, Philip D. Hodgkin, Kate L. Graham, Thomas W. Kay, Yifan Zhan, Andrew M. Lew
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Professional antigen presenting cells (APC) are the major activator of T cells that then hone to sites of inflammation. Using islet cell grafts, here the authors show that parenchymal cells can present antigen to activate CD8+T cells at inflammatory
Externí odkaz:
https://doaj.org/article/ddf258470896415aaf2e07fd3e6bba40
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is a myelopoietic growth factor that has pleiotropic effects not only in promoting the differentiation of immature precursors into polymorphonuclear neutrophils (PMNs), monocytes/macrophages (
Externí odkaz:
https://doaj.org/article/14ea31cf12ab47d6b2609cff66a36a2a
Autor:
Li Sun, Jai Rautela, Rebecca B. Delconte, Fernando Souza-Fonseca-Guimaraes, Emma M. Carrington, Robyn L. Schenk, Marco J. Herold, Nicholas D. Huntington, Andrew M. Lew, Yuekang Xu, Yifan Zhan
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
GM-CSF promotes myeloid differentiation of cultured bone marrow cells into cells of the granulocytic and monocytic lineage; the latter can further differentiate into monocytes/macrophages and dendritic cells. How GM-CSF selects for these different my
Externí odkaz:
https://doaj.org/article/e3b4072c949d4b46a0ceca89a0b17782