Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Andrew M Leifer"'
Publikováno v:
PLoS Biology, Vol 21, Iss 9, p e3002280 (2023)
Animals must integrate sensory cues with their current behavioral context to generate a suitable response. How this integration occurs is poorly understood. Previously, we developed high-throughput methods to probe neural activity in populations of C
Externí odkaz:
https://doaj.org/article/4f3871a5bb454f7db70c2c947706d78f
Publikováno v:
eLife, Vol 12 (2023)
Olfactory navigation is observed across species and plays a crucial role in locating resources for survival. In the laboratory, understanding the behavioral strategies and neural circuits underlying odor-taxis requires a detailed understanding of the
Externí odkaz:
https://doaj.org/article/7543f7c50da24042b482846846f90fc3
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 9, p e1010421 (2022)
Imaging neural activity in a behaving animal presents unique challenges in part because motion from an animal's movement creates artifacts in fluorescence intensity time-series that are difficult to distinguish from neural signals of interest. One ap
Externí odkaz:
https://doaj.org/article/7162956abf504098ac0e9a791642ef55
Publikováno v:
PLoS Biology, Vol 20, Iss 1, p e3001524 (2022)
We present a high-throughput optogenetic illumination system capable of simultaneous closed-loop light delivery to specified targets in populations of moving Caenorhabditis elegans. The instrument addresses three technical challenges: It delivers tar
Externí odkaz:
https://doaj.org/article/b6f43c5d62d74295866a78e9d95cde5d
Autor:
Xinwei Yu, Matthew S Creamer, Francesco Randi, Anuj K Sharma, Scott W Linderman, Andrew M Leifer
Publikováno v:
eLife, Vol 10 (2021)
We present an automated method to track and identify neurons in C. elegans, called ‘fast Deep Neural Correspondence’ or fDNC, based on the transformer network architecture. The model is trained once on empirically derived semi-synthetic data and
Externí odkaz:
https://doaj.org/article/2c551f23d16046408cff743aaf6c5dc6
Autor:
Kelsey M Hallinen, Ross Dempsey, Monika Scholz, Xinwei Yu, Ashley Linder, Francesco Randi, Anuj K Sharma, Joshua W Shaevitz, Andrew M Leifer
Publikováno v:
eLife, Vol 10 (2021)
We investigated the neural representation of locomotion in the nematode C. elegans by recording population calcium activity during movement. We report that population activity more accurately decodes locomotion than any single neuron. Relevant signal
Externí odkaz:
https://doaj.org/article/9542823fa5e241b9afc59aeeca9a932f
Publikováno v:
eLife, Vol 7 (2018)
A quantitative understanding of how sensory signals are transformed into motor outputs places useful constraints on brain function and helps to reveal the brain’s underlying computations. We investigate how the nematode Caenorhabditis elegans respo
Externí odkaz:
https://doaj.org/article/3a146832b61144fbab8c89f134c629bb
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 5, p e1005517 (2017)
Advances in optical neuroimaging techniques now allow neural activity to be recorded with cellular resolution in awake and behaving animals. Brain motion in these recordings pose a unique challenge. The location of individual neurons must be tracked
Externí odkaz:
https://doaj.org/article/4ceec120a7874de4b20cfcdacc4062e5
Autor:
Jamie L Donnelly, Christopher M Clark, Andrew M Leifer, Jennifer K Pirri, Marian Haburcak, Michael M Francis, Aravinthan D T Samuel, Mark J Alkema
Publikováno v:
PLoS Biology, Vol 11, Iss 4, p e1001529 (2013)
Monoamines provide chemical codes of behavioral states. However, the neural mechanisms of monoaminergic orchestration of behavior are poorly understood. Touch elicits an escape response in Caenorhabditis elegans where the animal moves backward and tu
Externí odkaz:
https://doaj.org/article/1aeaced454154094860040de72e3918b
Autor:
Francesco Randi, Andrew M. Leifer
Publikováno v:
Curr Opin Neurobiol
The compact nervous system of the nematode Caenorhabditis elegans makes it a powerful playground to study how neural dynamics constrained by neuroanatomy generate neural function and behavior. The ability to record neural activity from the whole brai