Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Andrew M Fry"'
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140975 (2015)
The Nek11 kinase is a potential mediator of the DNA damage response whose expression is upregulated in early stage colorectal cancers (CRCs). Here, using RNAi-mediated depletion, we examined the role of Nek11 in HCT116 WT and p53-null CRC cells expos
Externí odkaz:
https://doaj.org/article/3e53e015bcbe44df8ea10a2252752fe0
Autor:
Stephanie Jerman, Heather H Ward, Rebecca Lee, Carla A M Lopes, Andrew M Fry, Mary MacDougall, Angela Wandinger-Ness
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106330 (2014)
Mutation of the X-linked oral-facial-digital syndrome type 1 (OFD1) gene is embryonic lethal in males and results in craniofacial malformations and adult onset polycystic kidney disease in females. While the OFD1 protein localizes to centriolar satel
Externí odkaz:
https://doaj.org/article/e4a42c1091fb428a8b45d9812c0852c9
Publikováno v:
Cells, Vol 13, Iss 23, p 1954 (2024)
The EML4–ALK oncogene drives tumour progression in approximately 5% of cases of non-small-cell lung cancers. At least 15 EML4–ALK variants have been identified, which elicit differential responses to conventional ALK inhibitors. Unfortunately, mo
Externí odkaz:
https://doaj.org/article/d692f3eb5ada4108bcb59f1356a8c204
Autor:
Hugh R Woodland, Andrew M Fry
Publikováno v:
PLoS ONE, Vol 3, Iss 11, p e3778 (2008)
We have made a wide phylogenetic survey of Pix proteins, which are constituents of vertebrate centrioles in most eukaryotes. We have also surveyed the presence and structure of flagella or cilia and centrioles in these organisms, as far as is possibl
Externí odkaz:
https://doaj.org/article/c4faabb4618742478223c2e868e478e2
Autor:
Robert E. Turnbull, Louise Fairall, Almutasem Saleh, Emma Kelsall, Kyle L. Morris, T. J. Ragan, Christos G. Savva, Aditya Chandru, Christopher J. Millard, Olga V. Makarova, Corinne J. Smith, Alan M. Roseman, Andrew M. Fry, Shaun M. Cowley, John W. R. Schwabe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The MiDAC complex recruits class I histone deacetylases to chromatin but little is known about its precise structure and function. Here, the authors explore the role of MiDAC in the cell cycle and during mouse embryogenesis, and present cryoEM struct
Externí odkaz:
https://doaj.org/article/6a71d260306a424c936ce21edc133482
Autor:
Naushin L. Hindul, Amarjot Jhita, Daiana G. Oprea, Tasnim Alamgir Hussain, Oksana Gonchar, Miguel Angel Muro Campillo, Laura O'Regan, Masato T. Kanemaki, Andrew M. Fry, Kouji Hirota, Kayoko Tanaka
Publikováno v:
Biology Open, Vol 11, Iss 2 (2022)
The human retinal pigment epithelial RPE-1 cell line immortalized with hTERT retains a stable karyotype with a modal chromosome number of 46 and has been widely used to study physiological events in human cell culture systems. To facilitate inducible
Externí odkaz:
https://doaj.org/article/50b84e4115784de1b13ec0fe54f7eb8a
Autor:
Richard J. Wall, David J. P. Ferguson, Aline Freville, Blandine Franke-Fayard, Declan Brady, Mohammad Zeeshan, Andrew R. Bottrill, Sally Wheatley, Andrew M. Fry, Chris J. Janse, Hiroyuki Yamano, Anthony A. Holder, David S. Guttery, Rita Tewari
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract The anaphase promoting complex/cyclosome (APC/C) is a highly conserved multi-subunit E3 ubiquitin ligase that controls mitotic division in eukaryotic cells by tagging cell cycle regulators for proteolysis. APC3 is a key component that contri
Externí odkaz:
https://doaj.org/article/c4146aca53b342b192bb9f54c10c319c
Autor:
Kellie Lucken, Laura O'Regan, Jene Choi, Josephina Sampson, Sarah L. Pashley, Richard Bayliss, Sam Khan, Andrew M. Fry
Publikováno v:
Mol Cancer Res
EML4-ALK is an oncogenic fusion protein present in approximately 5% of non–small cell lung cancers (NSCLC). Alternative breakpoints in the gene encoding EML4 result in distinct variants that are linked to markedly different patient outcomes. Patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd948a3ba18c5b65023fae35a332fb3
https://doi.org/10.1158/1541-7786.mcr-21-1010
https://doi.org/10.1158/1541-7786.mcr-21-1010
Autor:
Andrew M. Fry, Sam Khan, Richard Bayliss, Sarah L. Pashley, Josephina Sampson, Jene Choi, Laura O'Regan, Kellie Lucken
Supplementary Figure from EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bcd3bad71aec51f613a94963a943449
https://doi.org/10.1158/1541-7786.22527450.v1
https://doi.org/10.1158/1541-7786.22527450.v1
Autor:
Dean A. Fennell, Andrew M. Fry, Paul Baas, Sam M. Janes, Aaron S. Mansfield, Michael Sheaff, Apostolos Nakas, Naomi Guppy, Laurel M. Schunselaar, Neelam Kumar, Aimee Parsons, Joanna Dzialo, Alan G. Dawson, Annabel J. Sharkey, Anita Singh, Laura O'Regan, Sara Busacca
Western blots quantification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d6be537882550eb523bf94f524030e
https://doi.org/10.1158/1535-7163.22521774.v1
https://doi.org/10.1158/1535-7163.22521774.v1