Zobrazeno 1 - 10
of 248
pro vyhledávání: '"Andrew M Fry"'
Publikováno v:
Cells, Vol 13, Iss 23, p 1954 (2024)
The EML4–ALK oncogene drives tumour progression in approximately 5% of cases of non-small-cell lung cancers. At least 15 EML4–ALK variants have been identified, which elicit differential responses to conventional ALK inhibitors. Unfortunately, mo
Externí odkaz:
https://doaj.org/article/d692f3eb5ada4108bcb59f1356a8c204
Autor:
Robert E. Turnbull, Louise Fairall, Almutasem Saleh, Emma Kelsall, Kyle L. Morris, T. J. Ragan, Christos G. Savva, Aditya Chandru, Christopher J. Millard, Olga V. Makarova, Corinne J. Smith, Alan M. Roseman, Andrew M. Fry, Shaun M. Cowley, John W. R. Schwabe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The MiDAC complex recruits class I histone deacetylases to chromatin but little is known about its precise structure and function. Here, the authors explore the role of MiDAC in the cell cycle and during mouse embryogenesis, and present cryoEM struct
Externí odkaz:
https://doaj.org/article/6a71d260306a424c936ce21edc133482
Autor:
Naushin L. Hindul, Amarjot Jhita, Daiana G. Oprea, Tasnim Alamgir Hussain, Oksana Gonchar, Miguel Angel Muro Campillo, Laura O'Regan, Masato T. Kanemaki, Andrew M. Fry, Kouji Hirota, Kayoko Tanaka
Publikováno v:
Biology Open, Vol 11, Iss 2 (2022)
The human retinal pigment epithelial RPE-1 cell line immortalized with hTERT retains a stable karyotype with a modal chromosome number of 46 and has been widely used to study physiological events in human cell culture systems. To facilitate inducible
Externí odkaz:
https://doaj.org/article/50b84e4115784de1b13ec0fe54f7eb8a
Autor:
Richard J. Wall, David J. P. Ferguson, Aline Freville, Blandine Franke-Fayard, Declan Brady, Mohammad Zeeshan, Andrew R. Bottrill, Sally Wheatley, Andrew M. Fry, Chris J. Janse, Hiroyuki Yamano, Anthony A. Holder, David S. Guttery, Rita Tewari
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract The anaphase promoting complex/cyclosome (APC/C) is a highly conserved multi-subunit E3 ubiquitin ligase that controls mitotic division in eukaryotic cells by tagging cell cycle regulators for proteolysis. APC3 is a key component that contri
Externí odkaz:
https://doaj.org/article/c4146aca53b342b192bb9f54c10c319c
Autor:
Kellie Lucken, Laura O'Regan, Jene Choi, Josephina Sampson, Sarah L. Pashley, Richard Bayliss, Sam Khan, Andrew M. Fry
Publikováno v:
Mol Cancer Res
EML4-ALK is an oncogenic fusion protein present in approximately 5% of non–small cell lung cancers (NSCLC). Alternative breakpoints in the gene encoding EML4 result in distinct variants that are linked to markedly different patient outcomes. Patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd948a3ba18c5b65023fae35a332fb3
https://doi.org/10.1158/1541-7786.mcr-21-1010
https://doi.org/10.1158/1541-7786.mcr-21-1010
Autor:
Andrew M. Fry, Sam Khan, Richard Bayliss, Sarah L. Pashley, Josephina Sampson, Jene Choi, Laura O'Regan, Kellie Lucken
Supplementary Figure from EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bcd3bad71aec51f613a94963a943449
https://doi.org/10.1158/1541-7786.22527450.v1
https://doi.org/10.1158/1541-7786.22527450.v1
Autor:
Dean A. Fennell, Andrew M. Fry, Paul Baas, Sam M. Janes, Aaron S. Mansfield, Michael Sheaff, Apostolos Nakas, Naomi Guppy, Laurel M. Schunselaar, Neelam Kumar, Aimee Parsons, Joanna Dzialo, Alan G. Dawson, Annabel J. Sharkey, Anita Singh, Laura O'Regan, Sara Busacca
Western blots quantification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d6be537882550eb523bf94f524030e
https://doi.org/10.1158/1535-7163.22521774.v1
https://doi.org/10.1158/1535-7163.22521774.v1
Autor:
Dean A. Fennell, Andrew M. Fry, Paul Baas, Sam M. Janes, Aaron S. Mansfield, Michael Sheaff, Apostolos Nakas, Naomi Guppy, Laurel M. Schunselaar, Neelam Kumar, Aimee Parsons, Joanna Dzialo, Alan G. Dawson, Annabel J. Sharkey, Anita Singh, Laura O'Regan, Sara Busacca
Prognostic effect of MAD2L1 in second line cohort. Kaplan Meier curve for overall survival (OS) in patients treated with vinorelbine second line (n=3) stratified according to MAD2L1 expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312bc1eec825c4153b74e0be8390484d
https://doi.org/10.1158/1535-7163.22521783.v1
https://doi.org/10.1158/1535-7163.22521783.v1
Figure S2 shows Hsp70 inhibition does not block clustering of acentrosomal spindle poles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a586ed4fe86a7695f12417adaa7a9cc8
https://doi.org/10.1158/0008-5472.22416138
https://doi.org/10.1158/0008-5472.22416138
Supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5a1c340f10475e65071d1611a85880
https://doi.org/10.1158/0008-5472.22416132
https://doi.org/10.1158/0008-5472.22416132