Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Andrew M, Sharkey"'
Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development
Autor:
Natalie Samper, Lilja Hardardottir, Delphine M. Depierreux, Soomin C. Song, Ayano Nakazawa, Ivan Gando, Tomoe Y. Nakamura, Andrew M. Sharkey, Carla R. Nowosad, Stefan Feske, Francesco Colucci, William A. Coetzee
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionInvolved in immunity and reproduction, natural killer (NK) cells offer opportunities to develop new immunotherapies to treat infections and cancer or to alleviate pregnancy complications. Most current strategies use cytokines or antibodie
Externí odkaz:
https://doaj.org/article/6c6109b7f67d40d592753d77bafa8ce3
Autor:
Oisín Huhn, Martin A. Ivarsson, Lucy Gardner, Mike Hollinshead, Jane C Stinchcombe, Puran Chen, Norman Shreeve, Olympe Chazara, Lydia E. Farrell, Jakob Theorell, Hormas Ghadially, Peter Parham, Gillian Griffiths, Amir Horowitz, Ashley Moffett, Andrew M. Sharkey, Francesco Colucci
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
As an interface between maternal and fetal tissues, decidua hosts immune cells specialized in fostering a successful pregnancy. Here the authors carry out high-dimensional characterization of function, morphology and surface markers of human decidual
Externí odkaz:
https://doaj.org/article/686fd2691411467caa9337f1f7add0f8
Autor:
Oisín Huhn, Xiaohui Zhao, Laura Esposito, Ashley Moffett, Francesco Colucci, Andrew M. Sharkey
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Innate lymphoid cells (ILCs) are the most abundant immune cells in the uterine mucosa both before and during pregnancy. Circumstantial evidence suggests they play important roles in regulating placental development but exactly how they contribute to
Externí odkaz:
https://doaj.org/article/5c5e926f0d8e4436a74bcd638f9cebd6
Autor:
Malwina Prater, Russell S. Hamilton, Hong Wa Yung, Andrew M. Sharkey, Paul Robson, N. Erlyani Abd Hamid, Eric Jauniaux, D. Stephen Charnock-Jones, Graham J. Burton, Tereza Cindrova-Davies
Publikováno v:
Biology Open, Vol 10, Iss 6 (2021)
The human placenta is exposed to major environmental changes towards the end of the first trimester associated with full onset of the maternal arterial placental circulation. Changes include a switch from histotrophic to hemotrophic nutrition, and a
Externí odkaz:
https://doaj.org/article/c0000155cc50416ebee1a032f109d811
Autor:
Iva Filipovic, Laura Chiossone, Paola Vacca, Russell S. Hamilton, Tiziano Ingegnere, Jean-Marc Doisne, Delia A. Hawkes, Maria Cristina Mingari, Andrew M. Sharkey, Lorenzo Moretta, Francesco Colucci
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Studying the uterine lymphocyte pool is difficult due to its dynamic nature induced by various pregnancy-related factors. Here the authors provide, using transcriptome data from sorted mouse group 1 innate lymphoid cells (ILC), a molecular atlas of t
Externí odkaz:
https://doaj.org/article/94147fd056164a368caaea3b7a7234be
Autor:
Tereza Cindrova-Davies, D. Stephen Charnock-Jones, Hong Wa Yung, N. Erlyani Abd Hamid, Malwina Prater, Eric Jauniaux, Paul Robson, Graham J. Burton, Andrew M. Sharkey, Russell S. Hamilton
Publikováno v:
Biology Open
article-version (VoR) Version of Record
Biology Open, Vol 10, Iss 6 (2021)
article-version (VoR) Version of Record
Biology Open, Vol 10, Iss 6 (2021)
The human placenta is exposed to major environmental changes towards the end of the first trimester associated with full onset of the maternal arterial placental circulation. Changes include a switch from histotrophic to hemotrophic nutrition, and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176bb86ad01095e76735f233d01d82a2
http://europepmc.org/articles/PMC8214423
http://europepmc.org/articles/PMC8214423
Autor:
Norman Shreeve, Mike Hollinshead, Hormas Ghadially, Lydia Farrell, Gillian M. Griffiths, Peter Parham, Francesco Colucci, Amir Horowitz, Olympe Chazara, Oisin Huhn, Martin A. Ivarsson, Andrew M. Sharkey, Jakob Theorell, Puran Chen, Ashley Moffett, Lucy Gardner, Jane C. Stinchcombe
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
During early pregnancy, decidual innate lymphoid cells (dILCs) interact with surrounding maternal cells and invading fetal extravillous trophoblasts (EVT). Here, using mass cytometry, we characterise five main dILC subsets: decidual NK cells (dNK)1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b72ad428b60b188fcd862e92e2cc98
Autor:
Colin Lee, Russell S. Hamilton, Bing Liu, Praveena Naidu, Christopher H. T. Lee, Anna Appios, Florent Ginhoux, Joana Cerveira, Graham J. Burton, Maria Donde, Andrew M. Sharkey, Ashley Moffett, Xiaohui Zhao, Roksana Dutkiewicz, Naomi McGovern, Jake R. Thomas
Publikováno v:
Journal of Experimental Medicine. 218
Hofbauer cells (HBCs) are a population of macrophages found in high abundance within the stroma of the first-trimester human placenta. HBCs are the only fetal immune cell population within the stroma of healthy placenta. However, the functional prope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b27ecd5e787081ca31db40fca13ade67
https://doi.org/10.1084/jem.20200891
https://doi.org/10.1084/jem.20200891
Autor:
Bing Liu, Anna Appios, Ashley Moffett, Jake R. Thomas, Florent Ginhoux, Russell S. Hamilton, Roksana Dutkiewicz, Graham J. Burton, Joana Cerveira, Praveena Naidu, Andrew M. Sharkey, Naomi McGovern, Christopher H. T. Lee, Colin Lee, Xiaohui Zhao, Maria Donde
Hofbauer cells (HBC) are a population of macrophages found in high abundance within the stroma of the first trimester human placenta. HBC are the only fetal immune cell population within the stroma of healthy placenta. However, the functional propert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff282df86f482a28bcbbea63c9cb318c
https://doi.org/10.1101/2020.09.03.279919
https://doi.org/10.1101/2020.09.03.279919
Autor:
Ulla Sovio, Andrew M. Sharkey, Christian Delles, Julian Parkhill, Susanne Lager, Sharon J. Peacock, D. Stephen Charnock-Jones, Justyna Dopierala, Marcus C. de Goffau, Francesca Gaccioli, Gordon C. S. Smith, Sungsam Gong, Judith Breuer, Cristina Venturini, Ashley Moffett, Emma Cook, Wai K. Lee
Publikováno v:
Nature microbiology, 5(7), 901-908. Nature Publishing Group
Pre-eclampsia (typically characterized by new-onset hypertension and proteinuria in the second half of pregnancy) represents a major determinant of the global burden of disease1,2. Its pathophysiology involves placental dysfunction, but the mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b7a54f6c3c092529a6fcd92540d52d
https://www.repository.cam.ac.uk/handle/1810/303646
https://www.repository.cam.ac.uk/handle/1810/303646