Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Andrew M, Lamade"'
Autor:
Andrew M. Lamade, Limin Wu, Haider H. Dar, Heather L. Mentrup, Indira H. Shrivastava, Michael W. Epperly, Claudette M. St Croix, Yulia Y. Tyurina, Tamil S. Anthonymuthu, Qin Yang, Aleksandr A. Kapralov, Zhentai Huang, Gaowei Mao, Andrew A. Amoscato, Zachary E. Hier, Margarita A. Artyukhova, Galina Shurin, Joel C. Rosenbaum, Peter J. Gough, John Bertin, Andrew P. VanDemark, Simon C. Watkins, Kevin P. Mollen, Ivet Bahar, Joel S. Greenberger, Valerian E. Kagan, Michael J. Whalen, Hülya Bayır
Publikováno v:
Redox Biology, Vol 50, Iss , Pp 102232- (2022)
Ferroptosis and necroptosis are two pro-inflammatory cell death programs contributing to major pathologies and their inhibition has gained attention to treat a wide range of disease states. Necroptosis relies on activation of RIP1 and RIP3 kinases. F
Externí odkaz:
https://doaj.org/article/f183853d46e94325b02ce4c0422c4965
Publikováno v:
Methods in Molecular Biology ISBN: 9781071628904
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24f317c96d559285a24b97d0da244634
https://doi.org/10.1007/978-1-0716-2891-1_2
https://doi.org/10.1007/978-1-0716-2891-1_2
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2609
Poly(ADP-ribose) polymerases (PARP) participate in diverse biological processes contributing to cellular homeostasis or exacerbating injury. PARP catalyzes the addition of ADP-ribose molecules (pADPr) to the target proteins, a process termed poly-ADP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6abe1a3755b1c0b494ec7ee08e1ab006
https://pubmed.ncbi.nlm.nih.gov/36515827
https://pubmed.ncbi.nlm.nih.gov/36515827
Autor:
Andrew M. Lamade, Tamil S. Anthonymuthu, Elizabeth M. Kenny, Hitesh Gidwani, Nicholas M. Krehel, Andrew A. Amoscato, Adam C. Straub, Valerian E. Kagan, Cameron Dezfulian, Hülya Bayır
Publikováno v:
Journal of Clinical and Translational Science, Vol 2, Pp 17-17 (2018)
OBJECTIVES/SPECIFIC AIMS: Neurological injury remains as the main limiting factor for overall recovery after cardiac arrest (CA). Currently available indicators of neurological injury are inadequate for early prognostication after return of spontaneo
Externí odkaz:
https://doaj.org/article/18461b9ed5e34375af3e4a57de3ab794
Lipidomics Detection of Brain Cardiolipins in Plasma Is Associated With Outcome After Cardiac Arrest
Autor:
Andrew A. Amoscato, Xiaotian Gao, Nicholas Krehel, Andrew M. Lamade, Tamil S. Anthonymuthu, Hülya Bayır, Valerian E. Kagan, Hitesh Gidwani, Adam C. Straub, Elizabeth M. Kenny, Amalea Misse, Cameron Dezfulian
Publikováno v:
Critical Care Medicine. 47:e292-e300
Objectives Brain mitochondrial dysfunction limits neurologic recovery after cardiac arrest. Brain polyunsaturated cardiolipins, mitochondria-unique and functionally essential phospholipids, have unprecedented diversification. Since brain cardiolipins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2673e04c10a5629b142301d05ccc33
https://doi.org/10.1097/ccm.0000000000003636
https://doi.org/10.1097/ccm.0000000000003636
Autor:
Elif Soysal, Tamil S. Anthonymuthu, Robert S. B. Clark, Elizabeth M. Kenny, Hülya Bayır, Valerian E. Kagan, Andrew M. Lamade
Publikováno v:
Neuropharmacology. 145:209-219
Mitochondria are a keystone of neuronal function, serving a dual role as sustainer of life and harbinger of death. While mitochondria are indispensable for energy production, a dysregulated mitochondrial network can spell doom for both neurons and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d008283610500f0c69d01969f93357e
https://doi.org/10.1016/j.neuropharm.2018.07.014
https://doi.org/10.1016/j.neuropharm.2018.07.014
Autor:
Georgy K. Vladimirov, Tamil S. Anthonymuthu, Valerian E. Kagan, Yulia Y. Tyurina, Caroline C. Philpott, Hülya Bayır, Qin Yang, Sarju J. Patel, Andrew M. Lamade, Andrew A. Amoscato
Publikováno v:
Cell Chem Biol
Redox balance is essential for normal brain, hence dis-coordinated oxidative reactions leading to neuronal death, including programs of regulated death, are commonly viewed as an inevitable pathogenic penalty for acute neuro-injury and neurodegenerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2b5eb6b71404057a4200049379c751
https://europepmc.org/articles/PMC7218794/
https://europepmc.org/articles/PMC7218794/
Autor:
Hülya Bayır, Andrew M. Lamade, Zachary E. Hier, Valerian E. Kagan, Yuan Gao, Tamil S. Anthonymuthu
Publikováno v:
Exp Neurol
Mitochondria are essential for neuronal function because they serve not only to sustain energy and redox homeostasis but also are harbingers of death. A dysregulated mitochondrial network can cascade until function is irreparably lost, dooming cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0b4520228a82a136227ce747ac6fec
https://doi.org/10.1016/j.expneurol.2020.113307
https://doi.org/10.1016/j.expneurol.2020.113307
Autor:
Lina Du, Robert S. B. Clark, Taber S. Maskrey, Hülya Bayır, Joel S. Greenberger, Peter Wipf, Simon C. Watkins, Tanja Krainz, Michael J. Calderon, Michael W. Epperly, Andrew M. Lamade
Publikováno v:
ACS chemical biology. 13(10)
The poly(ADP-ribose) polymerase (PARP) family of enzymes plays a crucial role in cellular and molecular processes including DNA damage detection and repair, and transcription; indeed, PARP inhibitors are under clinical evaluation as chemotherapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e797176401b8a18a53066d4388b6cea
https://pubmed.ncbi.nlm.nih.gov/30184433
https://pubmed.ncbi.nlm.nih.gov/30184433
Oxidative stress is a major contributor to secondary injury signaling cascades following traumatic brain injury (TBI). The role of lipid peroxidation in the pathophysiology of a traumatic insult to neural tissue is increasingly recognized. As the met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc45ca11a50c0568bd789194757a42a
https://europepmc.org/articles/PMC6098726/
https://europepmc.org/articles/PMC6098726/