Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Andrew M, Blagborough"'
Autor:
Holly M. Craven, Guilherme Nettesheim, Pietro Cicuta, Andrew M. Blagborough, Catherine J. Merrick
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 23, Iss , Pp 106-119 (2023)
Plasmodium falciparum is the deadliest causative agent of human malaria. This parasite has historically developed resistance to most drugs, including the current frontline treatments, so new therapeutic targets are needed. Our previous work on guanin
Externí odkaz:
https://doaj.org/article/e9371aa70d4440848aa14e1707bd2b4f
Autor:
Mitsuhiro Iyori, Andrew M. Blagborough, Tetsushi Mizuno, Yu-ichi Abe, Mio Nagaoka, Naoto Hori, Iroha Yamagoshi, Dari F. Da, William F. Gregory, Ammar A. Hasyim, Yutaro Yamamoto, Akihiko Sakamoto, Kunitaka Yoshida, Hiroaki Mizukami, Hisatoshi Shida, Shigeto Yoshida
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The Malaria Vaccine Technology Roadmap 2013 (World Health Organization) aims to develop safe and effective vaccines by 2030 that will offer at least 75% protective efficacy against clinical malaria and reduce parasite transmission. Here, we demonstra
Externí odkaz:
https://doaj.org/article/633da31b4040440cbce04c0fe0254da1
Autor:
Dari F. Da, Ruth McCabe, Bernard M. Somé, Pedro M. Esperança, Katarzyna A. Sala, Josua Blight, Andrew M. Blagborough, Floyd Dowell, Serge R. Yerbanga, Thierry Lefèvre, Karine Mouline, Roch K. Dabiré, Thomas S. Churcher
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract There is an urgent need for high throughput, affordable methods of detecting pathogens inside insect vectors to facilitate surveillance. Near-infrared spectroscopy (NIRS) has shown promise to detect arbovirus and malaria in the laboratory bu
Externí odkaz:
https://doaj.org/article/62f6f2a286bc46f793a6a8c2cea546b1
Autor:
Celia Miguel-Blanco, James M. Murithi, Ernest Diez Benavente, Fiona Angrisano, Katarzyna A. Sala, Donelly A. van Schalkwyk, Manu Vanaerschot, Frank Schwach, Matthew J. Fuchter, Oliver Billker, Colin J. Sutherland, Susana G. Campino, Taane G. Clark, Andrew M. Blagborough, David A. Fidock, Esperanza Herreros, Francisco Javier Gamo, Jake Baum, Michael J. Delves
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract New antimalarial therapeutics are needed to ensure that malaria cases continue to be driven down, as both emerging parasite resistance to frontline chemotherapies and mosquito resistance to current insecticides threaten control programmes. P
Externí odkaz:
https://doaj.org/article/900b4a91fa834a71a9fd17eeaf2b6009
Autor:
Marion Koch, Jaimini Cegla, Ben Jones, Yuning Lu, Ziad Mallat, Andrew M. Blagborough, Fiona Angrisano, Jake Baum
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-16 (2019)
Abstract Background Malaria disease commences when blood-stage parasites, called merozoites, invade human erythrocytes. Whilst the process of invasion is traditionally seen as being entirely merozoite-driven, emerging data suggests erythrocyte biophy
Externí odkaz:
https://doaj.org/article/d2cd4a8ad8ed4c72a248d250ee03ddc9
Autor:
Angela M. Minassian, Yrene Themistocleous, Sarah E. Silk, Jordan R. Barrett, Alison Kemp, Doris Quinkert, Carolyn M. Nielsen, Nick J. Edwards, Thomas A. Rawlinson, Fernando Ramos Lopez, Wanlapa Roobsoong, Katherine J.D. Ellis, Jee-Sun Cho, Eerik Aunin, Thomas D. Otto, Adam J. Reid, Florian A. Bach, Geneviève M.C. Labbé, Ian D. Poulton, Arianna Marini, Marija Zaric, Margaux Mulatier, Raquel Lopez Ramon, Megan Baker, Celia H. Mitton, Jason C. Sousa, Nattawan Rachaphaew, Chalermpon Kumpitak, Nongnuj Maneechai, Chayanut Suansomjit, Tianrat Piteekan, Mimi M. Hou, Baktash Khozoee, Kirsty McHugh, David J. Roberts, Alison M. Lawrie, Andrew M. Blagborough, Fay L. Nugent, Iona J. Taylor, Kimberly J. Johnson, Philip J. Spence, Jetsumon Sattabongkot, Sumi Biswas, Julian C. Rayner, Simon J. Draper
Publikováno v:
JCI Insight, Vol 6, Iss 23 (2021)
Controlled human malaria infection (CHMI) provides a highly informative means to investigate host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of new drugs and vaccines. However, unlike Plasmodium falciparum, well-charac
Externí odkaz:
https://doaj.org/article/8f5efdb3fb3a46f088a6c09f41c0d102
Autor:
Juan Feng, Xianchi Dong, Adam DeCosta, Yang Su, Fiona Angrisano, Katarzyna A Sala, Andrew M Blagborough, Chafen Lu, Timothy A Springer
Publikováno v:
eLife, Vol 10 (2021)
HAP2 is a transmembrane gamete fusogen found in multiple eukaryotic kingdoms and is structurally homologous to viral class II fusogens. Studies in Plasmodium have suggested that HAP2 is an attractive target for vaccines that block transmission of mal
Externí odkaz:
https://doaj.org/article/dd90b1a1d2494b23848064d636afc1d3
Autor:
Michelle K. Muthui, Eizo Takashima, Brian R. Omondi, Christine Kinya, William I. Muasya, Hikaru Nagaoka, Kennedy W. Mwai, Benedict Orindi, Juliana Wambua, Teun Bousema, Chris Drakeley, Andrew M. Blagborough, Kevin Marsh, Philip Bejon, Melissa C. Kapulu
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
IntroductionNaturally acquired immune responses against antigens expressed on the surface of mature gametocytes develop in individuals living in malaria-endemic areas. Evidence suggests that such anti-gametocyte immunity can block the development of
Externí odkaz:
https://doaj.org/article/c65a10b1bdfc4a4abc25bc57b3f0bb60
Autor:
Michelle K. Muthui, Alice Kamau, Teun Bousema, Andrew M. Blagborough, Philip Bejon, Melissa C. Kapulu
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/697ede72ec68499aba91f47ca265de1a
Publikováno v:
Parasites & Vectors, Vol 11, Iss 1, Pp 1-9 (2018)
Abstract Background The proportion of mosquitoes infected with malaria is an important entomological metric used to assess the intensity of transmission and the impact of vector control interventions. Currently, the prevalence of mosquitoes with sali
Externí odkaz:
https://doaj.org/article/25eead0e07c045babdd2295dafc5158b