Výsledky vyhledávání - "Andrew Leger"

Systemic Delivery of a Peptide-Linked Morpholino Oligonucleotide Neutralizes Mutant RNA Toxicity in a Mouse Model of Myotonic Dystrophy

Autor: Seng H. Cheng, Carol A. Nelson, Peter A. Piepenhagen, Errin Roberts, Leocadia M. Mosquea, Nicholas P. Clayton, Andrew Leger, I-Huan Wu, Bruce M. Wentworth, Lucy Phillips, Weeden Timothy E

Publikováno v: Nucleic Acid Therapeutics. 23:109-117

Expansions of CUG trinucleotide sequences in RNA transcripts provide the basis for toxic RNA gain-of-function that leads to detrimental changes in RNA metabolism. A CTG repeat element normally resides in the 3' untranslated region of the dystrophia m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d930ec74bd66f0aa9a93d03fa5b068
https://doi.org/10.1089/nat.2012.0404

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Targeting nuclear RNA for in vivo correction of myotonic dystrophy

Autor: A. Robert MacLeod, Seng H. Cheng, Charles A. Thornton, Andrew Leger, Masayuki Nakamori, C. Frank Bennett, Thurman M. Wheeler, Bruce M. Wentworth, Sanjay K. Pandey

Publikováno v: Nature

Antisense oligonucleotides (ASOs) hold promise for gene-specific knockdown in diseases that involve RNA or protein gain-of-function effects. In the hereditary degenerative disease myotonic dystrophy type 1 (DM1), transcripts from the mutant allele co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad41c6118dd3efb0545c857b06c93e09
https://doi.org/10.1038/nature11362

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Adeno-associated virus-mediated expression of acid sphingomyelinase decreases atherosclerotic lesion formation in apolipoprotein E−/− mice

Autor: Rod Moreland, Seng H. Cheng, Nelson S. Yew, Peter A. Piepenhagen, Canwen Jiang, Lingyun Li, Akihiro Urabe, Robin J. Ziegler, Andrew Leger, Zhengyu Luo, Joshua Pacheco, Wei-Lien Chuang, Leocadia M. Mosquea, Kristin M. Taylor

Publikováno v: The Journal of Gene Medicine. 13:324-332

Background The secretory form of acid sphingomyelinase (ASM) is postulated to play a key role in the retention and aggregation of lipoproteins in the subendothelial space of the arterial wall by converting sphingomyelin in lipoproteins into ceramide.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83908894092f2d94827abbdf30914bd1
https://doi.org/10.1002/jgm.1575

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Pilates-Based Therapeutic Exercise: Effect on Subjects With Nonspecific Chronic Low Back Pain and Functional Disability: A Randomized Controlled Trial

Autor: Rochenda Rydeard, Andrew Leger, Drew Smith

Publikováno v: Journal of Orthopaedic & Sports Physical Therapy. 36:472-484

A randomized controlled trial, prestest-posttest design, with a 3-, 6-, and 12-month follow-up.To investigate the efficacy of a therapeutic exercise approach in a population with chronic low back pain (LBP).Therapeutic approaches developed from the P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1243ff8cd08c87912205e1f942501714
https://doi.org/10.2519/jospt.2006.2144

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Antisense Oligonucleotide-mediated Suppression of Muscle Glycogen Synthase 1 Synthesis as an Approach for Substrate Reduction Therapy of Pompe Disease

Autor: Seng H. Cheng, Rodney J. Moreland, Kristin M. Taylor, Lucy Phillips, Weeden Timothy E, Nicholas P. Clayton, Ronald K. Scheule, Bruce M. Wentworth, Carol A. Nelson, Andrew Leger

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)
Molecular Therapy. Nucleic Acids

Pompe disease is an autosomal recessive disorder caused by a deficiency of acid α -glucosidase (GAA; EC 3.2.1.20) and the resultant progressive lysosomal accumulation of glycogen in skeletal and cardiac muscles. Enzyme replacement therapy using reco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::911c15bddfbdb866d101ff4a32b9cac7
http://www.sciencedirect.com/science/article/pii/S2162253116303432

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Rowing Performance and Selected Descriptive, Field, and Laboratory Variables

Autor: Andrew Leger, John F. Kramer, Donald H. Paterson, Alan Morrow

Publikováno v: Canadian Journal of Applied Physiology. 19:174-184

The purpose of this study was to determine the relationships among measures of rowing performance and selected descriptive, field, and laboratory variables. Rowing performance of 20 intercollegiate oarswomen was assessed using a 2,500-m time test on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ad4003b85e5d727eb61a19ad954100
https://doi.org/10.1139/h94-013

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Inhibition of osteoclastogenesis by prolyl hydroxylase inhibitor dimethyloxallyl glycine

Autor: Leocadia M. Mosquea, Seng H. Cheng, Nelson S. Yew, Antonius Song, Canwen Jiang, Adam J. Belanger, Andrew Leger, Allison Altobelli

Publikováno v: Journal of bone and mineral metabolism. 28(5)

Studies examining the effects of hypoxia upon osteoclast biology have consistently revealed a stimulatory effect; both osteoclast differentiation and resorption activity have been shown to be enhanced in the presence of hypoxia. In the present study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0847334d79c71b28935644fdd0a374
https://pubmed.ncbi.nlm.nih.gov/20300790

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Oarside and Nonoarside Knee Extensor Strength Measures and Their Relationship to Rowing Ergometer Performance

Autor: Alan Morrow, Andrew Leger, John F. Kramer

Publikováno v: Journal of Orthopaedic & Sports Physical Therapy. 14:213-219

Laterality difference in strength characterize some sports and occupations. The purposes of this study were to compare oarside and nonoarside knee extensor strength of intercollegiate rowers and to determine the relationship between joint-specific st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff42114ee66503d74dd868e4b50efe3
https://doi.org/10.2519/jospt.1991.14.5.213

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