Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Andrew Leask"'
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109864- (2024)
Summary: Hippo was first identified in a genetic screen as a protein that suppressed proliferation and cell growth. Subsequently, it was shown that hippo acted in a so-called canonical cascade to suppress Yorkie, the Drosophila equivalent of Yes-acti
Externí odkaz:
https://doaj.org/article/ed87311d106e47aba613071282f03ca0
Autor:
Antonio Tejera-Muñoz, Marcelino Cortés, Alianet Rodriguez-Rodriguez, Lucia Tejedor-Santamaria, Vanessa Marchant, Sandra Rayego-Mateos, Maria José Gimeno-Longas, Andrew Leask, Tri Q. Nguyen, María Martín, Jose Tuñón, Isabel Rodríguez, Marta Ruiz-Ortega, Raul R. Rodrigues-Díez
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9617 (2024)
Cellular Communication Network Factor 2 (CCN2) is a matricellular protein implicated in cell communication and microenvironmental signaling. Overexpression of CCN2 has been documented in various cardiovascular pathologies, wherein it may exert either
Externí odkaz:
https://doaj.org/article/c63d7390702945688665da6d961f7ee4
Autor:
Jeffrey C. Y. Yu, Yixiao Zeng, Kaiqiong Zhao, Tianyuan Lu, Kathleen Oros Klein, Inés Colmegna, Maximilien Lora, Sahir R. Bhatnagar, Andrew Leask, Celia M. T. Greenwood, Marie Hudson
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-13 (2023)
Abstract Background Abnormal DNA methylation is thought to contribute to the onset and progression of systemic sclerosis. Currently, the most comprehensive assay for profiling DNA methylation is whole-genome bisulfite sequencing (WGBS), but its preci
Externí odkaz:
https://doaj.org/article/8a108d0cfda846c09201b863b8138be0
Publikováno v:
JCI Insight, Vol 8, Iss 1 (2023)
Vascular smooth muscle cell (SMC) phenotypic switching is widely recognized as a key mechanism responsible for the pathogenesis of several aortic diseases, such as aortic aneurysm. Cellular communication network factor 2 (CCN2), often upregulated in
Externí odkaz:
https://doaj.org/article/b9ad8eafcba542bb87b6422d15e6e490
Autor:
Asmaa Fadl, Andrew Leask
Publikováno v:
Cells, Vol 12, Iss 16, p 2021 (2023)
Adult human gingival fibroblasts (HGFs), the most abundant cells in the oral cavity, are essential for maintaining oral homeostasis. Compared with other tissues, adult oral mucosal wounds heal regeneratively, without scarring. Relative to fibroblasts
Externí odkaz:
https://doaj.org/article/812ebc61bf264f029329f490d205c4e4
Autor:
Dylan Dieters-Castator, Paola M. Dantonio, Matt Piaseczny, Guihua Zhang, Jiahui Liu, Miljan Kuljanin, Stephen Sherman, Michael Jewer, Katherine Quesnel, Eun Young Kang, Martin Köbel, Gabrielle M. Siegers, Andrew Leask, David Hess, Gilles Lajoie, Lynne-Marie Postovit
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 4, Pp 375-390 (2021)
The tumor microenvironment (TME) is an important mediator of breast cancer progression. Cancer-associated fibroblasts constitute a major component of the TME and may originate from tissue-associated fibroblasts or infiltrating mesenchymal stromal cel
Externí odkaz:
https://doaj.org/article/12aee79287f34bb1b635b9f1f1242d5c
Autor:
Craig M. Keenan, Lorenzo Ramos-Mucci, Ioannis Kanakis, Peter I. Milner, Andrew Leask, David Abraham, George Bou-Gharios, Blandine Poulet
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 7 (2020)
CCN2 is a matricellular protein involved in several crucial biological processes. In particular, CCN2 is involved in cartilage development and in osteoarthritis. Ccn2 null mice exhibit a range of skeletal dysmorphisms, highlighting its importance in
Externí odkaz:
https://doaj.org/article/cf3a3ff5ec074a19ac7c76eb85a76bb0
Autor:
Sohyun Moon, Sangmi Lee, Joy Ann Caesar, Sarah Pruchenko, Andrew Leask, James A. Knowles, Jose Sinon, Brahim Chaqour
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101184- (2020)
Summary: Connective tissue growth factor (CTGF) or cellular communication network 2 (CCN2) is a matricellular protein essential for normal embryonic development and tissue repair. CTGF exhibits cell- and context-dependent activities, but CTGF functio
Externí odkaz:
https://doaj.org/article/0dd03b78704f430a8a85d4861f6ae3ca
Autor:
Katsunari Makino, Tomoko Makino, Lukasz Stawski, Kenneth E. Lipson, Andrew Leask, Maria Trojanowska
Publikováno v:
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-10 (2017)
Abstract Background Systemic sclerosis (SSc) is characterized by fibrosis of the skin and internal organs. Although the involvement of connective tissue growth factor (CTGF/CCN2) has been well-documented in SSc fibrosis, the therapeutic potential of
Externí odkaz:
https://doaj.org/article/86d5419d01c34e3b8a0c7d7152c4e373
Autor:
Nikoleta Tellios, Jillian C. Belrose, Alexander C. Tokarewicz, Cindy Hutnik, Hong Liu, Andrew Leask, Michael Motolko, Miho Iijima, Sunil K. Parapuram
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Fundamental cell signaling mechanisms that regulate dynamic remodeling of the extracellular matrix (ECM) in mechanically loaded tissues are not yet clearly understood. Trabecular meshwork (TM) tissue in the eye is under constant mechanical s
Externí odkaz:
https://doaj.org/article/8bb48815166d45aeb9c93eacf9646328