Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Andrew L. Schilb"'
Autor:
Da Sun, Wenyu Sun, Song-Qi Gao, Jonathan Lehrer, Amirreza Naderi, Cheng Wei, Sangjoon Lee, Andrew L. Schilb, Josef Scheidt, Ryan C. Hall, Elias I. Traboulsi, Krzysztof Palczewski, Zheng-Rong Lu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 823-835 (2022)
Stargardt disease (STGD) is the most common form of inherited retinal genetic disorders and is often caused by mutations in ABCA4. Gene therapy has the promise to effectively treat monogenic retinal disorders. However, clinically approved adeno-assoc
Externí odkaz:
https://doaj.org/article/cb04137658994b97a05895718c16a714
Autor:
Andrew L. Schilb, Josef H. Scheidt, Amita M. Vaidya, Zhanhu Sun, Da Sun, Sangjoon Lee, Zheng-Rong Lu
Publikováno v:
Pharmaceuticals, Vol 14, Iss 10, p 1016 (2021)
Nucleic acids are promising for a variety of therapies, such as cancer therapy and the gene therapy of genetic disorders. The therapeutic efficacy of nucleic acids is reliant on the ability of their efficient delivery to the cytosol of the target cel
Externí odkaz:
https://doaj.org/article/05d85eeca6e14b68ab0a1dd323b7a976
Autor:
Amita M. Vaidya, Ryan C. W. Hall, Ramamurthy Gopalakrishnan, Zheng-Rong Lu, Nadia Ayat, Zhanhu Sun, Da Sun, Laura M Hertz, Josef H Scheidt, Andrew L Schilb
Publikováno v:
Pharmaceutical Research. 38:1405-1418
To investigate the effectiveness of targeted ECO/miR-200c in modulating tumor microenvironment and treating triple negative breast cancer (TNBC) using non-invasive magnetic resonance molecular imaging (MRMI) of extradomain B fibronectin (EDB-FN) with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e8cc7449b8f6f92de2e83187100c1af
https://doi.org/10.1007/s11095-021-03083-z
https://doi.org/10.1007/s11095-021-03083-z
Autor:
Andrew L Schilb, Wenyu Sun, Josef H Scheidt, Amirreza Naderi, Songqi Gao, Krzysztof Palczewski, Da Sun, Sang-Joon Lee, Zheng-Rong Lu, Timothy S. Kern, Cheng Wei
Publikováno v:
J Control Release
It is still a challenge to develop gene replacement therapy for retinal disorders caused by mutations in large genes, such as Stargardt disease (STGD). STGD is caused by mutations in ABCA4 gene. Previously, we have developed an effective non-viral ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93110ca5e6d7334e4980df2be2f166ae
https://doi.org/10.1016/j.jconrel.2020.12.010
https://doi.org/10.1016/j.jconrel.2020.12.010
Publikováno v:
Cancer Communications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d145df209f1c1300c893bb84ac1400
https://doi.org/10.1002/cac2.12011
https://doi.org/10.1002/cac2.12011
Autor:
Da Sun, Andrew L Schilb, Ryan C. W. Hall, Michelle Yin, Zheng-Rong Lu, Josef H Scheidt, X. Liu, Nadia Ayat, Zhanhu Sun, Amita M. Vaidya
Publikováno v:
Nucleic Acid Ther
Nanoparticle based siRNA formulations often suffer from aggregation and loss of function during storage. We in this study report a frozen targeted RGD-polyethylene glycol (PEG)-ECO/siβ3 nanoparticle formulation with a prolonged shelf life and preser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab0134b57a72294bfd33eacb2978b416
https://doi.org/10.1089/nat.2019.0784
https://doi.org/10.1089/nat.2019.0784
Autor:
Da Sun, Zheng Han, Rui Xin, Hongfa Jiang, Amirreza Naderi, Zhanhu Sun, Nadia Ayat, Zheng-Rong Lu, Andrew L Schilb, Peter Qiao, Amita M. Vaidya
Publikováno v:
Bioconjugate Chemistry
CRISPR/Cas9 system is a promising approach for gene editing in gene therapy. Effective gene editing requires safe and efficient delivery of CRISPR/Cas9 system in target cells. Several new multifunctional pH-sensitive amino lipids were designed and sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ce8a4457b0382d1d751b3333dc4fbd
http://europepmc.org/articles/PMC6429435
http://europepmc.org/articles/PMC6429435
Autor:
Andrew L, Schilb, Nadia R, Ayat, Amita M, Vaidya, Laura M, Hertz, Ryan C, Hall, Josef H, Scheidt, Da, Sun, Zhanhu, Sun, Ramamurthy, Gopalakrishnan, Zheng-Rong, Lu
Publikováno v:
Pharmaceutical research. 38(8)
To investigate the effectiveness of targeted ECO/miR-200c in modulating tumor microenvironment and treating triple negative breast cancer (TNBC) using non-invasive magnetic resonance molecular imaging (MRMI) of extradomain B fibronectin (EDB-FN) with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa69e5fa1373653c7cf6168c8e8bd6fe
https://pubmed.ncbi.nlm.nih.gov/34389916
https://pubmed.ncbi.nlm.nih.gov/34389916
Autor:
Zhanhu Sun, Zheng-Rong Lu, Amita M. Vaidya, Nadia Ayat, Da Sun, Hannah Gilmore, Xujie Liu, Siyuan He, Victoria Qian, Josef H Scheidt, Hongfa Jiang, Andrew L Schilb, William P. Schiemann
Publikováno v:
Bioconjugate chemistry. 30(3)
Long non-coding RNAs (lncRs), by virtue of their versatility and multilevel gene regulation, have emerged as attractive pharmacological targets for treating heterogenous and complex malignancies like triple-negative breast cancer (TNBC). Despite mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e71bae1c803dc5fc9b4c7f45404ae13f
https://pubmed.ncbi.nlm.nih.gov/30739442
https://pubmed.ncbi.nlm.nih.gov/30739442