Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Andrew L. Routh"'
Autor:
Jun Cao, Sunil K. Verma, Elizabeth Jaworski, Stephanie Mohan, Chloe K. Nagasawa, Kempaiah Rayavara, Amanda Sooter, Sierra N. Miller, Richard J. Holcomb, Mason J. Powell, Ping Ji, Nathan D. Elrod, Eda Yildirim, Eric J. Wagner, Vsevolod Popov, Nisha J. Garg, Andrew L. Routh, Muge N. Kuyumcu-Martinez
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109910- (2021)
Summary: RBFOX2, which has a well-established role in alternative splicing, is linked to heart diseases. However, it is unclear whether RBFOX2 has other roles in RNA processing that can influence gene expression in muscle cells, contributing to heart
Externí odkaz:
https://doaj.org/article/1c3849ba190a44869afb25b4370a9f1a
Autor:
Antonio Muruato, Michelle N. Vu, Bryan A. Johnson, Meredith E. Davis-Gardner, Abigail Vanderheiden, Kumari Lokugamage, Craig Schindewolf, Patricia A. Crocquet-Valdes, Rose M. Langsjoen, Jessica A. Plante, Kenneth S. Plante, Scott C. Weaver, Kari Debbink, Andrew L. Routh, David Walker, Mehul S. Suthar, Pei-Yong Shi, Xuping Xie, Vineet D. Menachery
Publikováno v:
PLoS Biology, Vol 19, Iss 11 (2021)
The emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a pandemic causing significant damage to public health and the economy. Efforts to understand the mechanisms of Coronavirus Disease 2019 (COVID-19) have bee
Externí odkaz:
https://doaj.org/article/46c6d8bd9d624bacbff3fc599b9a701c
Autor:
Stephanea L. Sotcheff, John Yun-Chung Chen, Nathan Elrod, Jun Cao, Elizabeth Jaworski, Mugé N. Kuyumcu-Martinez, Pei-Yong Shi, Andrew L. Routh
Publikováno v:
Pathogens, Vol 11, Iss 8, p 936 (2022)
Flaviviruses are small RNA viruses that are mainly transmitted via arthropod vectors and are found in tropic and sub-tropical regions. Most infections are asymptomatic (90–95%), but symptoms can be as severe as hemorrhagic fever and encephalitis. O
Externí odkaz:
https://doaj.org/article/7d6a1038bd204cb69ef29048e3090e98
Autor:
Michelle N. Vu, Dorothea R. Morris, R. Elias Alvarado, Kumari G. Lokugamage, Yiyang Zhou, Leah K. Estes, Alyssa M. McLeland, Craig Schindewolf, Jessica A. Plante, Yani P. Ahearn, Angelica L. Morgan, William M. Meyers, Jordan T. Murray, Scott C. Weaver, David H. Walker, William K. Russell, Andrew L. Routh, Kenneth S. Plante, Vineet Menachery
Publikováno v:
bioRxiv
SARS-CoV-2 Omicron variants emerged in 2022 with >30 novel amino acid mutations in the spike protein alone. While most studies focus on the impact of receptor binding domain changes, mutations in the C-terminal of S1 (CTS1), adjacent to the furin cle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf8007697b39d3c4252dfed1a310974
https://doi.org/10.1101/2023.04.17.536926
https://doi.org/10.1101/2023.04.17.536926
Autor:
Craig Schindewolf, Kumari Lokugamage, Michelle N. Vu, Bryan A. Johnson, Dionna Scharton, Jessica A. Plante, Birte Kalveram, Patricia A. Crocquet-Valdes, Stephanea Sotcheff, Elizabeth Jaworski, Rojelio E. Alvarado, Kari Debbink, Matthew D. Daugherty, Scott C. Weaver, Andrew L. Routh, David H. Walker, Kenneth S. Plante, Vineet D. Menachery
Publikováno v:
Journal of virology, vol 97, iss 2
bioRxiv
bioRxiv
Understanding the molecular basis of innate immune evasion by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important consideration for designing the next wave of therapeutics. Here, we investigate the role of the nonstructural p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc3b14dd84ecc851034f4895dcc1263
https://escholarship.org/uc/item/2vh402qq
https://escholarship.org/uc/item/2vh402qq
Autor:
Stephanea Sotcheff, Yiyang Zhou, Jason Yeung, Yan Sun, John E Johnson, Bruce E Torbett, Andrew L Routh
Publikováno v:
GigaScience. 12
Background Genetic recombination is a tremendous source of intrahost diversity in viruses and is critical for their ability to rapidly adapt to new environments or fitness challenges. While viruses are routinely characterized using high-throughput se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6323e62fdd1d6b521fd119acd5846311
https://doi.org/10.1093/gigascience/giad009
https://doi.org/10.1093/gigascience/giad009
Bipartite viral RNA genome heterodimerization influences genome packaging and virion thermostability
Autor:
Yiyang Zhou, Andrew L. Routh
Diverse RNA-RNA interactions occur throughout the lifecycle of RNA viruses, including genome dimerization or multimerization through non-covalent association of two or more genomic segments. Both homo-dimerization of retrovirus genomic RNA and hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83d04112c99ee4e9c72fd91b9c21eb02
https://doi.org/10.1101/2022.07.29.501896
https://doi.org/10.1101/2022.07.29.501896
Autor:
Michelle N. Vu, Kumari G. Lokugamage, Jessica A. Plante, Dionna Scharton, Aaron O. Bailey, Stephanea Sotcheff, Daniele M. Swetnam, Bryan A. Johnson, Craig Schindewolf, R. Elias Alvarado, Patricia A. Crocquet-Valdes, Kari Debbink, Scott C. Weaver, David H. Walker, William K. Russell, Andrew L. Routh, Kenneth S. Plante, Vineet D. Menachery
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The furin cleavage site (FCS), an unusual feature in the SARS-CoV-2 spike protein, has been spotlighted as a factor key to facilitating infection and pathogenesis by increasing spike processing. Similarly, the QTQTN motif directly upstream of the FCS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a99ed449b0f8fc20980923a0adc649
https://doi.org/10.1073/pnas.2205690119
https://doi.org/10.1073/pnas.2205690119
Autor:
Jason Yeung, Andrew L Routh
Motivation Recombination is an essential driver of virus evolution and adaption, giving rise to new chimeric viruses, structural variants, sub-genomic RNAs and defective RNAs. Next-generation sequencing (NGS) of virus samples, either from experimenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c1c9c051388d7339a00ea1f6304530
https://doi.org/10.1101/2022.04.06.487215
https://doi.org/10.1101/2022.04.06.487215
Genetic recombination is a tremendous source of intra-host diversity in viruses and is critical for their ability to rapidly adapt to new environments or fitness challenges. While viruses are routinely characterized using high-throughput sequencing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09997dd036245fcd235325dbf75d28a2
https://doi.org/10.1101/2022.03.12.484090
https://doi.org/10.1101/2022.03.12.484090