Výsledky vyhledávání - "Andrew L. Olson"

The Solution Structures and Interaction of SinR and SinI: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis

Autor: Morgan E. Milton, Michael T. Santoro, Benjamin G. Bobay, Katherine H. Myers, Daniel B. Kearns, John Cavanagh, Sean D. Stowe, Andrew L. Olson, Richele J. Thompson, Erik A. Feldmann, G. Logan Draughn

Publikováno v: J Mol Biol

Bacteria have developed numerous protection strategies to ensure survival in harsh environments, with perhaps the most robust method being the formation of a protective biofilm. In biofilms, bacterial cells are embedded within a matrix that is compos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32ca89d60e7f6652ade3872b4d4903c
https://doi.org/10.1016/j.jmb.2019.08.019

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The Structure of the Biofilm-controlling Response Regulator BfmR from Acinetobacter baumannii Reveals Details of Its DNA-binding Mechanism

Autor: John Cavanagh, Morgan E. Milton, G. Logan Draughn, Braden M. Roth, Erik A. Feldmann, Luis A. Actis, Andrew L. Olson, Benjamin G. Bobay, Richele J. Thompson, Christopher Davies

Publikováno v: Journal of Molecular Biology. 430:806-821

The rise of drug-resistant bacterial infections coupled with decreasing antibiotic efficacy poses a significant challenge to global health care. Acinetobacter baumannii is an insidious, emerging bacterial pathogen responsible for severe nosocomial in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad360a1a9a1e8aa0d2a967bc91010df2
https://doi.org/10.1016/j.jmb.2018.02.002

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Structure and DNA-Binding Traits of the Transition State Regulator AbrB

Autor: Ashley T. Tucker, Erik J. Soderblom, M. Arthur Moseley, Richele J. Thompson, John Cavanagh, Andrew L. Olson, Benjamin G. Bobay

Publikováno v: Structure. 22(11):1650-1656

SummaryThe AbrB protein from Bacillus subtilis is a DNA-binding global regulator controlling the onset of a vast array of protective functions under stressful conditions. Such functions include biofilm formation, antibiotic production, competence dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66883ae43296e7cb9334e34820653f7e

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Solution structures of Mycobacterium tuberculosis thioredoxin C and models of intact thioredoxin system suggest new approaches to inhibitor and drug design

Autor: Daniel S. Sem, Terrence S. Neumann, Andrew L. Olson, Sheng Cai

Publikováno v: Proteins: Structure, Function, and Bioinformatics. 81:675-689

Here, we report the NMR solution structures of Mycobacterium tuberculosis (M. tuberculosis) thioredoxin C in both oxidized and reduced states, with discussion of structural changes that occur in going between redox states. The NMR solution structure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77ec262d8b85b5e3f05bde300001bbbf
https://doi.org/10.1002/prot.24228

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1H, 13C, and 15N resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis

Autor: John Cavanagh, Andrew L. Olson, Christian Melander, Benjamin G. Bobay

Publikováno v: Biomolecular NMR Assignments. 6:95-98

The AbrB protein is a transcription factor that regulates the expression of numerous essential genes during the cells transition phase state. AbrB from Bacillus anthracis is, nototriously, the principal protein responsible for anthrax toxin gene expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578c115698d7ad560674ea11733220c8
https://doi.org/10.1007/s12104-011-9333-2

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Substrate induced structural and dynamics changes in human phosphomevalonate kinase and implications for mechanism

Autor: Timothy J. Herdendorf, Daniel S. Sem, Patchareenart Saparpakorn, Sheng Cai, Henry M. Miziorko, Huili Yao, Andrew L. Olson, Supa Hannongbua

Publikováno v: Proteins: Structure, Function, and Bioinformatics. 75:127-138

Phosphomevalonate kinase (PMK) catalyzes an essential step in the mevalonate pathway, which is the only pathway for synthesis of isoprenoids and steroids in humans. PMK catalyzes transfer of the gamma-phosphate of ATP to mevalonate 5-phosphate (M5P)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::512abb6a3629be7032e2a361079d5dd5
https://doi.org/10.1002/prot.22228

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Binding Synergy and Cooperativity in Dihydrodipicolinate Reductase: Implications for Mechanism and the Design of Biligand Inhibitors

Autor: Daniel S. Sem, Xia Ge, Andrew L. Olson, Sheng Cai

Publikováno v: Biochemistry. 47:9966-9980

Dihydrodipicolinate reductase (DHPR) is a homotetramer that catalyzes reduction of dihydrodipicolinate (DHP). We recently reported a biligand inhibitor ( K i = 100 nM) of DHPR, comprised of fragments that bind in the NADH (CRAA = catechol rhodanine a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb87939d8e49c082f2573b9b3982b925
https://doi.org/10.1021/bi8007005

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A DNA mimic: the structure and mechanism of action for the anti-repressor protein AbbA

Autor: Andrew L. Olson, Erik J. Soderblom, Allison V. Banse, Benjamin G. Bobay, Kristen M. Varney, Richele J. Thompson, Ashley T. Tucker, M. Arthur Moseley, John Cavanagh, Richard Losick

Publikováno v: Journal of molecular biology. 426(9)

Bacteria respond to adverse environmental conditions by switching on the expression of large numbers of genes that enable them to adapt to unfavorable circumstances. In Bacillus subtilis, many adaptive genes are under the negative control of the glob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea04d1e0e65de634a1615fd3b4796fb
https://pubmed.ncbi.nlm.nih.gov/24534728

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