Výsledky vyhledávání - "Andrew L Markley"

Akademický článek

An organic acid based counter selection system for cyanobacteria.

Autor: Matthew B Begemann, Erin K Zess, Eric M Walters, Emily F Schmitt, Andrew L Markley, Brian F Pfleger

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e76594 (2013)

Cyanobacteria are valuable organisms for studying the physiology of photosynthesis and carbon fixation, as well as metabolic engineering for the production of fuels and chemicals. This work describes a novel counter selection method for the cyanobact

Externí odkaz: https://doaj.org/article/acd17325ef6749d58ac88b8b42584c03

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Genetically Encoded Detection of Biosynthetic Protease Inhibitors

Autor: Levi Kramer, Ankur Sarkar, Tom Foderaro, Andrew L. Markley, Jessica Lee, Hannah Edstrom, Shajesh Sharma, Eden Gill, Matthew J. Traylor, Jerome M. Fox

Publikováno v: ACS Synth Biol

Proteases are an important class of drug targets that continue to drive inhibitor discovery. These enzymes are prone to resistance mutations, yet their promise for treating viral diseases and other disorders continues to grow. This study develops a g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c845f52aee116a522eddfcb066ca552b
https://pubmed.ncbi.nlm.nih.gov/36574400

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Enhancing Photosynthetic Production of Glycogen-Rich Biomass for Use as a Fermentation Feedstock

Autor: Austin D. Comer, Joshua P. Abraham, Alexander J. Steiner, Travis C. Korosh, Andrew L. Markley, Brian F. Pfleger

Publikováno v: Frontiers in Energy Research, Vol 8 (2020)
Front Energy Res

Current sources of fermentation feedstocks, i.e. corn, sugar cane, or plant biomass, fall short of demand for liquid transportation fuels and commodity chemicals in the United States. Aquatic phototrophs including cyanobacteria have the potential to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af54ed26c980b28307b599a10f0ddb26
https://www.frontiersin.org/article/10.3389/fenrg.2020.00093/full

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Engineering photosynthetic production of L-lysine

Autor: Laura L. McGinley, Travis C. Korosh, Katherine D. McMahon, Andrew L. Markley, Brian F. Pfleger, Ryan L. Clark

Publikováno v: Metabolic engineering

L -lysine and other amino acids are commonly produced through fermentation using strains of heterotrophic bacteria such as Corynebacterium glutamicum. Given the large amount of sugar this process consumes, direct photosynthetic production is intrigui

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fadef9c56751e703143506578948edb3
https://doi.org/10.1016/j.ymben.2017.10.010

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A metabolic pathway for catabolizing levulinic acid in bacteria

Autor: Daniel E. Agnew, Kelly M. Wetmore, Tippapha Pisithkul, Ryan L. Clark, Daniel Amador-Noguez, Morgan N. Price, Jacqueline M. Rand, Joshua M. Thiede, Christopher R. Mehrer, Yumi Suh, Andrew L. Markley, Candace E. Campbell, Adam P. Arkin, Brian F. Pfleger, Adam M. Deutschbauer, Jayashree Ray

Publikováno v: Nature microbiology
Rand, JM; Pisithkul, T; Clark, RL; Thiede, JM; Mehrer, CR; Agnew, DE; et al.(2017). A metabolic pathway for catabolizing levulinic acid in bacteria. Nature Microbiology, 2(12), 1624-1634. doi: 10.1038/s41564-017-0028-z. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/7wj2z10w

© 2017 The Author(s). Microorganisms can catabolize a wide range of organic compounds and therefore have the potential to perform many industrially relevant bioconversions. One barrier to realizing the potential of biorefining strategies lies in our

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca4ff3609553c375087abc854e6f6ad
https://doi.org/10.1038/s41564-017-0028-z

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Discovery of a widely distributed toxin biosynthetic gene cluster

Autor: Aaron Wohlrab, Victor Nizet, Douglas A. Mitchell, David Gonzalez, Pieter C. Dorrestein, Jack E. Dixon, Shaun W. Lee, Andrew L. Markley, Mary E. Hensler

Publikováno v: Proceedings of the National Academy of Sciences. 105:5879-5884

Bacteriocins represent a large family of ribosomally produced peptide antibiotics. Here we describe the discovery of a widely conserved biosynthetic gene cluster for the synthesis of thiazole and oxazole heterocycles on ribosomally produced peptides.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b16ca4e179797d86bfaa92cf068e16
https://doi.org/10.1073/pnas.0801338105

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A transcription activator-like effector (TALE) induction system mediated by proteolysis

Autor: Charles B Johnson, Matthew F. Copeland, Brian F. Pfleger, Mark C. Politz, Andrew L. Markley

Publikováno v: Nature chemical biology

Simple and predictable trans-acting regulatory tools are needed in the fields of synthetic biology and metabolic engineering to build complex genetic circuits and optimize the levels of native and heterologous gene products. Transcription activator-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7dead2d16f7d814edd8e1ed9ac8249b
https://pubmed.ncbi.nlm.nih.gov/26854666

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HIV protease inhibitors block streptolysin S production

Autor: Andrew L. Markley, Shaun W. Lee, Tucker Maxson, Caitlin D. Deane, Douglas A. Mitchell, Courtney L. Cox, Evelyn M. Molloy

Publikováno v: ACS chemical biology. 10(5)

Streptolysin S (SLS) is a post-translationally modified peptide cytolysin that is produced by the human pathogen Streptococcus pyogenes. SLS belongs to a large family of azole-containing natural products that are biosynthesized via an evolutionarily

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29bfaa3cd756e052ed754ffd94de0984
https://pubmed.ncbi.nlm.nih.gov/25668590

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