Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Andrew L Markhard"'
Autor:
Robert S Rogers, Hong Wang, Timothy J Durham, Jonathan A Stefely, Norah A Owiti, Andrew L Markhard, Lev Sandler, Tsz-Leung To, Vamsi K Mootha
Publikováno v:
PLoS Biology, Vol 21, Iss 5, p e3002117 (2023)
There is widespread interest in identifying interventions that extend healthy lifespan. Chronic continuous hypoxia delays the onset of replicative senescence in cultured cells and extends lifespan in yeast, nematodes, and fruit flies. Here, we asked
Externí odkaz:
https://doaj.org/article/56d5adc8ffd44d2ca1e52f0708949c87
Autor:
Tovah E Markowitz, Daniel Suarez, Hannah G Blitzblau, Neem J Patel, Andrew L Markhard, Amy J MacQueen, Andreas Hochwagen
Publikováno v:
PLoS Genetics, Vol 13, Iss 7, p e1006928 (2017)
Meiotic chromosomes assemble characteristic "axial element" structures that are essential for fertility and provide the chromosomal context for meiotic recombination, synapsis and checkpoint signaling. Whether these meiotic processes are equally depe
Externí odkaz:
https://doaj.org/article/1fee624aee554ce98f34df8a55422188
Autor:
Rebecca D. Ganetzky, Andrew L. Markhard, Irene Yee, Sheila Clever, Alan Cahill, Hardik Shah, Zenon Grabarek, Tsz-Leung To, Vamsi K. Mootha
Publikováno v:
New England Journal of Medicine. 387:1395-1403
We describe the case of identical twin boys who presented with low body weight despite excessive caloric intake. An evaluation of their fibroblasts showed elevated oxygen consumption and decreased mitochondrial membrane potential. Exome analysis reve
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Oxygen plays a key role in supporting life on our planet. It is particularly important in higher eukaryotes where it boosts bioenergetics as a thermodynamically favorable terminal electron acceptor and has important roles in cell signaling and develo
Autor:
Owen S. Skinner, Sarah E. Calvo, Tslil Ast, Vamsi K. Mootha, Tsz-Leung To, Andrew L. Markhard, Isha H. Jain
Publikováno v:
Cell
Summary Human cells are able to sense and adapt to variations in oxygen levels. Historically, much research in this field has focused on hypoxia-inducible factor (HIF) signaling and reactive oxygen species (ROS). Here, we perform genome-wide CRISPR g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed7ba8216e693cd0fa7706faefeb23a1
https://europepmc.org/articles/PMC7293541/
https://europepmc.org/articles/PMC7293541/
Autor:
Andrew L. Markhard, Mert Bozbeyoglu, Melissa J.S. MacEwen, Olga Goldberger, Forrest Bradford, Vamsi K. Mootha, Yasemin Sancak
The mitochondrial uniporter is calcium-activated calcium channel complex critical for cellular signaling and bioenergetics. MCU, the pore-forming subunit of the uniporter, contains two transmembrane domains and is found in all major eukaryotic taxa.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bfd0cd13b811278942ba29788bd4ee4
Autor:
Rohit Sharma, Gary Yellen, Russell P. Goodman, Hardik Shah, Clary B. Clish, Andrew L. Markhard, Yu-Han H. Hsu, Anupam Patgiri, Hye Lim Noh, Jason K. Kim, Ricard Masia, Owen S. Skinner, Amy Deik, Olga Goldberger, Sujin Suk, Vamsi K. Mootha, Joel N. Hirschhorn
Publikováno v:
Nature
The cellular NADH/NAD+ ratio is fundamental to biochemistry, but the extent to which it reflects versus drives metabolic physiology in vivo is poorly understood. Here we report the in vivo application of Lactobacillus brevis (Lb)NOX1, a bacterial wat
Autor:
Vamsi K. Mootha, Tanxing Cui, Andrew L. Markhard, Yao Cong, Ying Dong, Bo OuYang, Liangliang Kong, Yasemin Sancak, Kirill Oxenoid, Zhijun Liu, James J. Chou, Chan Cao, Zenon Grabarek
Publikováno v:
Nature
Mitochondria from many eukaryotic clades take up large amounts of calcium (Ca(2+)) via an inner membrane transporter called the uniporter. Transport by the uniporter is membrane potential dependent and sensitive to ruthenium red or its derivative Ru3
Autor:
Vamsi K. Mootha, Andrew L. Markhard, Olga Goldberger, Yasemin Sancak, Melissa J.S. MacEwen, Mert Bozbeyoglu, Forrest Bradford
Publikováno v:
Life Science Alliance
Using clues from evolution, chimeric proteins, and biochemical methods, this work identifies a new domain in mitochondrial calcium uniporter that determines its dependence on its binding partner EMRE.
The mitochondrial calcium uniporter (MCU) is
The mitochondrial calcium uniporter (MCU) is
Autor:
Yasemin Sancak, Namrata D. Udeshi, Sarah E. Calvo, Toshimori Kitami, Andrew L. Markhard, Olga Goldberger, Steven A. Carr, David E. Clapham, Andrew A. Li, Kimberli J. Kamer, Erika Kovács-Bogdán, Dipayan Chaudhuri, Vamsi K. Mootha
Publikováno v:
Science. 342:1379-1382
The mitochondrial uniporter is a highly selective calcium channel in the organelle's inner membrane. Its molecular components include the EF-hand-containing calcium-binding proteins mitochondrial calcium uptake 1 (MICU1) and MICU2 and the pore-formin