Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Andrew L Kleinhenz"'
Autor:
Robin C Su, Apurva Lad, Joshua D Breidenbach, Thomas M Blomquist, William T Gunning, Prabhatchandra Dube, Andrew L Kleinhenz, Deepak Malhotra, Steven T Haller, David J Kennedy
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0225604 (2019)
Non-alcoholic fatty liver disease (NAFLD) is a growing global health concern. With a propensity to progress towards non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma, NAFLD is an important link amongst a multitude of comor
Externí odkaz:
https://doaj.org/article/2f53741577374690a840c45f2cc3b178
Autor:
Joshua D. Breidenbach, Benjamin W. French, Lauren M. Stanoszek, John-Paul Lavik, Krishna Rao Maddipati, Sanduni H. Premathilaka, David Baliu-Rodriguez, Bivek Timalsina, Vaishnavi Aradhyula, Shivani C. Patel, Apurva Lad, Irum Syed, Andrew L. Kleinhenz, Thomas M. Blomquist, Amira Gohara, Prabhatchandra Dube, Shungang Zhang, Dhilhani Faleel, Fatimah K. Khalaf, Dragan Isailovic, R. Mark Wooten, James C. Willey, Jeffrey R. Hammersley, Nikolai N. Modyanov, Deepak Malhotra, Lance D. Dworkin, David J. Kennedy, Steven T. Haller
Publikováno v:
Toxins, Vol 16, Iss 11, p 470 (2024)
Harmful algal blooms are increasing globally and pose serious health concerns releasing cyanotoxins. Microcystin-LR (MC-LR), one of the most frequently produced cyanotoxins, has recently been detected in aerosols generated by the normal motions of af
Externí odkaz:
https://doaj.org/article/350057d751ae422988e188704ad72c15
Autor:
Apurva Lad, Jonathan Hunyadi, Jacob Connolly, Joshua D. Breidenbach, Fatimah K. Khalaf, Prabhatchandra Dube, Shungang Zhang, Andrew L. Kleinhenz, David Baliu-Rodriguez, Dragan Isailovic, Terry D. Hinds, Cara Gatto-Weis, Lauren M. Stanoszek, Thomas M. Blomquist, Deepak Malhotra, Steven T. Haller, David J. Kennedy
Publikováno v:
Antioxidants, Vol 11, Iss 8, p 1625 (2022)
We have previously shown in a murine model of Non-alcoholic Fatty Liver Disease (NAFLD) that chronic, low-dose exposure to the Harmful Algal Bloom cyanotoxin microcystin-LR (MC-LR), resulted in significant hepatotoxicity including micro-vesicular lip
Externí odkaz:
https://doaj.org/article/86730d6c10e0400c9209b5650c3fb6b5
Autor:
Apurva Lad, Joshua D. Breidenbach, Robin C. Su, Jordan Murray, Rebecca Kuang, Alison Mascarenhas, John Najjar, Shivani Patel, Prajwal Hegde, Mirella Youssef, Jason Breuler, Andrew L. Kleinhenz, Andrew P. Ault, Judy A. Westrick, Nikolai N. Modyanov, David J. Kennedy, Steven T. Haller
Publikováno v:
Life, Vol 12, Iss 3, p 418 (2022)
Freshwater harmful algal blooms (HABs) are increasing in number and severity worldwide. These HABs are chiefly composed of one or more species of cyanobacteria, also known as blue-green algae, such as Microcystis and Anabaena. Numerous HAB cyanobacte
Externí odkaz:
https://doaj.org/article/b4f1e5c70ae541ef850241cf17fbcfe7
Autor:
Kennedy, Prabhatchandra Dube, Vaishnavi Aradhyula, Apurva Lad, Fatimah K. Khalaf, Joshua D. Breidenbach, Eshita Kashaboina, Snigdha Gorthi, Shangari Varatharajan, Travis W. Stevens, Jacob A. Connolly, Sophia M. Soehnlen, Ambika Sood, Amulya Marellapudi, Meghana Ranabothu, Andrew L. Kleinhenz, Oliver Domenig, Lance D. Dworkin, Deepak Malhotra, Steven T. Haller, David J.
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 10062
Diet-induced models of chronic kidney disease (CKD) offer several advantages, including clinical relevance and animal welfare, compared with surgical models. Oxalate is a plant-based, terminal toxic metabolite that is eliminated by the kidneys throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::67562422036ae9cb20fdbb24a8547e24
Autor:
Robin C. Su, Emily A. Warner, Joshua D. Breidenbach, Apurva Lad, Thomas M. Blomquist, Andrew L. Kleinhenz, Nikolai Modyanov, Deepak Malhotra, David J. Kennedy, Steven T. Haller
Publikováno v:
Biomedicines, Vol 8, Iss 6, p 149 (2020)
Inflammatory Bowel Disease (IBD) is one of the most common gastrointestinal (GI) disorders around the world, and includes diagnoses such as Crohn’s disease and ulcerative colitis. The etiology of IBD is influenced by genetic and environmental facto
Externí odkaz:
https://doaj.org/article/a0ff3e4211a04986a3d7b9f54005d729
Autor:
Apurva Lad, Robin C. Su, Joshua D. Breidenbach, Paul M. Stemmer, Nicholas J. Carruthers, Nayeli K. Sanchez, Fatimah K. Khalaf, Shungang Zhang, Andrew L. Kleinhenz, Prabhatchandra Dube, Chrysan J. Mohammed, Judy A. Westrick, Erin L. Crawford, Dilrukshika Palagama, David Baliu-Rodriguez, Dragan Isailovic, Bruce Levison, Nikolai Modyanov, Amira F. Gohara, Deepak Malhotra, Steven T. Haller, David J. Kennedy
Publikováno v:
Toxins, Vol 11, Iss 9, p 486 (2019)
Microcystins are potent hepatotoxins that have become a global health concern in recent years. Their actions in at-risk populations with pre-existing liver disease is unknown. We tested the hypothesis that the No Observed Adverse Effect Level (NOAEL)
Externí odkaz:
https://doaj.org/article/2486fc94b80c4ec5a5d1d9530aca15c5
Autor:
Robin C. Su, Thomas M. Blomquist, Andrew L. Kleinhenz, Fatimah K. Khalaf, Prabhatchandra Dube, Apurva Lad, Joshua D. Breidenbach, Chrysan J. Mohammed, Shungang Zhang, Caitlin E. Baum, Deepak Malhotra, David J. Kennedy, Steven T. Haller
Publikováno v:
Toxins, Vol 11, Iss 6, p 371 (2019)
Inflammatory Bowel Disease (IBD) represents a collection of gastrointestinal disorders resulting from genetic and environmental factors. Microcystin-leucine arginine (MC-LR) is a toxin produced by cyanobacteria during algal blooms and demonstrates bi
Externí odkaz:
https://doaj.org/article/a2d5604988ab4e67a0ba4fd38addc2e7
Autor:
Prabhatchandra Dube, Fatimah K. Khalaf, Armelle DeRiso, Chrysan J. Mohammed, Jacob A. Connolly, Dhanushya Battepati, Apurva Lad, Joshua D. Breidenbach, Andrew L. Kleinhenz, Bella Khatib-Shahidi, Mitra Patel, Iman Tassavvor, Amira F. Gohara, Deepak Malhotra, Eric E. Morgan, Steven T. Haller, David J. Kennedy
Publikováno v:
Biomedicines; Volume 10; Issue 9; Pages: 2301
Paraoxonase-1 (PON-1) is a hydrolytic enzyme associated with HDL, contributing to its anti-inflammatory, antioxidant, and anti-atherogenic properties. Deficiencies in PON-1 activity result in oxidative stress and detrimental clinical outcomes in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea34a11a8bdd54de70366e0f606d8d5
https://pubmed.ncbi.nlm.nih.gov/36140402
https://pubmed.ncbi.nlm.nih.gov/36140402
Autor:
Joshua D. Breidenbach, Benjamin W. French, Tamiya T. Gordon, Andrew L. Kleinhenz, Fatimah K. Khalaf, James C. Willey, Jeffrey R. Hammersley, R. Mark Wooten, Erin L. Crawford, Nikolai N. Modyanov, Deepak Malhotra, Justin G. Teeguarden, Steven T. Haller, David J. Kennedy
Publikováno v:
Environment international. 169
Harmful algal blooms plague bodies of freshwater globally. These blooms are often composed of outgrowths of cyanobacteria capable of producing the heptapeptide Microcystin-LR (MC-LR) which is a well-known hepatotoxin. Recently, MC-LR has been detecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275b398dfd166777dd0de2cbf1696f7c
https://pubmed.ncbi.nlm.nih.gov/36137425
https://pubmed.ncbi.nlm.nih.gov/36137425