Výsledky vyhledávání - "Andrew L, Feldman"

Akademický článek

Multiomic analysis identifies a high-risk signature that predicts early clinical failure in DLBCL

Publikováno v: Blood Cancer Journal, Vol 14, Iss 1, Pp 1-11 (2024)

Abstract Recent genetic and molecular classification of DLBCL has advanced our knowledge of disease biology, yet were not designed to predict early events and guide anticipatory selection of novel therapies. To address this unmet need, we used an int

Externí odkaz: https://doaj.org/article/01ad00fd8b6b4753b3568b00e0172eef

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Akademický článek

Translating prognostic quantification of c-MYC and BCL2 from tissue microarrays to whole slide images in diffuse large B-cell lymphoma using deep learning

Autor: Thomas E. Tavolara, M. Khalid Khan Niazi, Andrew L. Feldman, David L. Jaye, Christopher Flowers, Lee A.D. Cooper, Metin N. Gurcan

Publikováno v: Diagnostic Pathology, Vol 19, Iss 1, Pp 1-13 (2024)

Abstract Background c-MYC and BCL2 positivity are important prognostic factors for diffuse large B-cell lymphoma. However, manual quantification is subject to significant intra- and inter-observer variability. We developed an automated method for qua

Externí odkaz: https://doaj.org/article/7c68eb8f1a58429a94ccbcc88f6fa070

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Akademický článek

Relationship between BCL2 mutations and follicular lymphoma outcome in the chemoimmunotherapy era

Autor: Cristina Correia, Matthew J. Maurer, Samantha J. McDonough, Paula A. Schneider, Paige E. Ross, Anne J. Novak, Andrew L. Feldman, James R. Cerhan, Susan L. Slager, Thomas E. Witzig, Bruce W. Eckloff, Hu Li, Grzegorz S. Nowakowski, Scott H. Kaufmann

Publikováno v: Blood Cancer Journal, Vol 13, Iss 1, Pp 1-9 (2023)

Abstract How to identify follicular lymphoma (FL) patients with low disease burden but high risk for early progression is unclear. Building on a prior study demonstrating the early transformation of FLs with high variant allele frequency (VAF) BCL2 m

Externí odkaz: https://doaj.org/article/2262c5bd3f494450bb8803bb96a17ff2

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Akademický článek

Lack of intrafollicular memory CD4 + T cells is predictive of early clinical failure in newly diagnosed follicular lymphoma

Publikováno v: Blood Cancer Journal, Vol 11, Iss 7, Pp 1-11 (2021)

Abstract Despite a characteristic indolent course, a substantial subset of follicular lymphoma (FL) patients has an early relapse with a poor outcome. Cells in the microenvironment may be a key contributor to treatment failure. We used a discovery an

Externí odkaz: https://doaj.org/article/0b1f331407cc43f2b978d504ee1e2e66

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Akademický článek

MAPK and JAK-STAT pathways dysregulation in plasmablastic lymphoma

Publikováno v: Haematologica, Vol 106, Iss 10 (2021)

Plasmablastic lymphoma (PBL) is an aggressive B-cell lymphoma with an immunoblastic/large-cell morphology and terminal B-cell differentiation. The differential diagnosis from Burkitt lymphoma, plasma cell myeloma and some variants of diffuse large B-

Externí odkaz: https://doaj.org/article/ad4c0e78008445a184ba4c5d1368f5bd

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Akademický článek

Case Report: Multiple Chromosomal Translocations Including Novel CIITA-CREBBP Fusion and Mutations in a Follicular Lymphoma

Autor: Huan-You Wang, Ethan S. Sokol, Aaron M. Goodman, Andrew L. Feldman, Carolyn M. Mulroney

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

The pathogenesis of follicular lymphoma is a multi-step process, in which chromosomal translocation between immunoglobulin heavy chain (IgH) and anti-apoptotic B-cell lymphoma 2 (BCL2), namely IgH-BCL2, is an earliest step, followed by other genetic/

Externí odkaz: https://doaj.org/article/04874c71b5154931a9da52c9d1ecacca

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Increasing tissue requirements in lymphoma trials may exclude patients with high-risk disease or worse prognosis

Autor: Sanjal H. Desai, Raphael Mwangi, Wern Lynn Ng, Rebecca L. King, Matthew J. Maurer, James R. Cerhan, Andrew L. Feldman, Umar Farooq, Eric Mou, Thomas M. Habermann, Carrie A. Thompson, Yucai Wang, Thomas E. Witzig, Grzegorz S. Nowakowski

Publikováno v: Blood Advances. 6:6180-6186

An enhanced understanding of the molecular heterogeneity of diffuse large B-cell lymphoma (DLBCL) has opened the door to clinical trials evaluating novel agents with subtype-specific activity. It is an emerging question whether core needle biopsies (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd6fd76625c3d2a4420a33f5a63ebad
https://doi.org/10.1182/bloodadvances.2022007569

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Akademický článek

Molecular profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma

Publikováno v: Haematologica, Vol 106, Iss 6 (2020)

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a recently characterized T-cell malignancy that has raised significant patient safety concerns and led to worldwide impact on the implants used and clinical management of patients

Externí odkaz: https://doaj.org/article/b160bd80598140648c1c52e59ac73758

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