Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Andrew Kotliar"'
Autor:
Gloria C. Koo, Laurie A. Castonguay, Mary Jo Staruch, Randal M. Bugianesi, John P. Felix, George A. Doss, Robert S. Slaughter, Marty S. Springer, Andrew Kotliar, Sookhee Ha, Kathleen M. Rupprecht, William H. Parsons, Gregory J. Kaczorowski, Kashmira Shah, Shouwu Miao, Jianming Bao, Maria L. Garcia, Frank Kayser, Robert K. Baker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:447-451
Kv1.3, the voltage-gated potassium channel in human T cells, represents a new target for treating immunosuppression and autoimmune diseases. Correolide (1), a pentacyclic natural product, is a potent and selective Kv1.3 channel blocker. Simplificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b217212f1114b7e5c9d40397d6232c7
https://doi.org/10.1016/j.bmcl.2004.10.058
https://doi.org/10.1016/j.bmcl.2004.10.058
Autor:
Maria L. Garcia, Frank Kayser, Peter J. Sinclair, Mary Jo Staruch, Andrew Kotliar, Nancy N. Tsou, William H. Parsons, Marty S. Springer, Gloria C. Koo, Kathleen M. Rupprecht, William A. Schmalhofer, Gregory J. Kaczorowski, Robert S. Slaughter, Joung L. Goulet, Kashmira Shah, Jianming Bao, Xingfang J. Hong, Frederick Wong, Shouwu Miao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1161-1164
The voltage-gated potassium channel, Kv1.3, is present in human T-lymphocytes. Blockade of Kv1.3 results in T-cell depolarization, inhibition of T-cell activation, and attenuation of immune responses in vivo. A class of benzamide Kv1.3 channel inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd33db6982167b726fc36794cabfa008
https://doi.org/10.1016/s0960-894x(03)00014-3
https://doi.org/10.1016/s0960-894x(03)00014-3
Autor:
Frank Kayser, Jianming Bao, William H. Parsons, Andrew Kotliar, Shouwu Miao, George A. Doss, Robert K. Baker, Kathleen M. Rupprecht
Publikováno v:
Organic Letters. 4:1871-1873
[reaction: see text] Pentacyclic triterpenoid natural product correolide (1) was converted to ketone 2 via ozonolysis. An unusual fragmentation reaction of ketone 2 with LiCl was discovered. This reaction is general among several similar substrates e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607d92d986d46735f3a34cdffdda07ba
https://doi.org/10.1021/ol020053g
https://doi.org/10.1021/ol020053g