Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Andrew Kneynsberg"'
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-5 (2024)
Abstract Tau is a microtubule-associated protein that is regulated by post-translational modifications. The most studied of these modifications is phosphorylation, which affects Tau’s aggregation and loss- and gain-of-functions, including the inter
Externí odkaz:
https://doaj.org/article/5740702fac0f4501aea30acf98b8a9d9
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-5 (2023)
Abstract Synaptic degeneration is a precursor of synaptic and neuronal loss in neurodegenerative diseases such as Alzheimer’s disease (AD) and frontotemporal dementia with tau pathology (FTD-tau), a group of primary tauopathies. A critical role in
Externí odkaz:
https://doaj.org/article/373093bdf15547e2980ab7ec67eb4114
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-14 (2021)
Abstract The synthesis of new proteins is a fundamental aspect of cellular life and is required for many neurological processes, including the formation, updating and extinction of long-term memories. Protein synthesis is impaired in neurodegenerativ
Externí odkaz:
https://doaj.org/article/4127815f43ac4aa0bd01fb124c002f62
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
Tauopathies are a diverse group of diseases featuring progressive dying-back neurodegeneration of specific neuronal populations in association with accumulation of abnormal forms of the microtubule-associated protein tau. It is well-established that
Externí odkaz:
https://doaj.org/article/391733b04f894983bb7c900b47fd37ae
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120120 (2015)
In situ hybridization (ISH) is an extremely useful tool for localizing gene expression and changes in expression to specific cell populations in tissue samples across numerous research fields. Typically, a research group will put forth significant ef
Externí odkaz:
https://doaj.org/article/dc104955ad3a421280d603faa6aebcd2
Publikováno v:
Nature Reviews Neuroscience. 22:723-740
The synapse has emerged as a critical neuronal structure in the degenerative process of Alzheimer disease (AD), in which the pathogenic signals of two key players - amyloid-β (Aβ) and tau - converge, thereby causing synaptic dysfunction and cogniti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481791f0c534a270bb014c14e11308f5
https://doi.org/10.1038/s41583-021-00531-y
https://doi.org/10.1038/s41583-021-00531-y
Autor:
Pranesh Padmanabhan, Andrew Kneynsberg, Esteban Cruz, Rumelo Amor, Jean‐Baptiste Sibarita, Jürgen Götz
Publikováno v:
The EMBO journal. 41(19)
Accumulation of aggregates of the microtubule-binding protein Tau is a pathological hallmark of Alzheimer's disease. While Tau is thought to primarily associate with microtubules, it also interacts with and localizes to the plasma membrane. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3033d462461485cd2a2668e5766aab5
https://pubmed.ncbi.nlm.nih.gov/36004506
https://pubmed.ncbi.nlm.nih.gov/36004506
Autor:
Pranesh Padmanabhan, Andrew Kneynsberg, Esteban Cruz Gonzalez, Rumelo Amor, Jean-Baptiste Sibarita, Jürgen Götz
Accumulation of Tau aggregates is a pathological hallmark of Alzheimer’s disease, but little is known about where these aggregates assemble and how stable these assemblies are. Using quantitative, single-molecule imaging, we show that Tau exhibits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4ad80f0340e2eb26cce7eae4fe77891
https://doi.org/10.1101/2022.02.04.479198
https://doi.org/10.1101/2022.02.04.479198
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-14 (2021)
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-14 (2021)
The synthesis of new proteins is a fundamental aspect of cellular life and is required for many neurological processes, including the formation, updating and extinction of long-term memories. Protein synthesis is impaired in neurodegenerative disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c447bad1540bd05d9fd17ddbd685a9
http://europepmc.org/articles/PMC8214309
http://europepmc.org/articles/PMC8214309
Autor:
Scott T. Brady, Rebecca L. Mueller, Gerardo Morfini, Benjamin Combs, Andrew Kneynsberg, Sarah L. Morris, Nicholas M. Kanaan, Kyle Christensen, Collin Richards
Publikováno v:
The Journal of Neuroscience
Pathologic tau modifications are characteristic of Alzheimer's disease and related dementias, but mechanisms of tau toxicity continue to be debated. Inherited mutations in tau cause early onset frontotemporal lobar dementias (FTLD-tau) and are common
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c15e6627b47ebcaa800c80931b863b
https://pubmed.ncbi.nlm.nih.gov/34607969
https://pubmed.ncbi.nlm.nih.gov/34607969