Výsledky vyhledávání - "Andrew Keith Forrest"

Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues

Autor: Sula Anne Armstrong, Pamela Brown, Darren Jason Mitchell, Stephen Rittenhouse, Dieter Hamprecht, Andrew Keith Forrest, Royston C. B. Copley, Peter J. O'Hanlon, John S. Elder, Richard L. Jarvest, Murray J. B. Brown, John M. Berge, David R. Witty

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 14:3937-3941

Potent inhibitors of bacterial methionyl tRNA synthetase (MRS) have previously been reported. Through SAR of the quinolone moiety, the right hand side pharmacophore for MRS inhibition has now been defined as an NH-C-NH functionality in the context of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a00b883541bfe1e20d22ba34c7e3b15
https://doi.org/10.1016/j.bmcl.2004.05.070

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Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens

Autor: Andrew Keith Forrest, Murray J. B. Brown, Martin Hibbs, Valerie Berry, Robert J. Sheppard, Deborah Dee Jaworski, John S. Elder, Courtney Slater-Radosti, Peter J. O'Hanlon, Helen F. Boyd, John M. Berge, Richard L. Jarvest, Andrew J. Pope, Angela Worby, Andrew P. Fosberry, Daniel R. Gentry, Stephen Rittenhouse

Publikováno v: Journal of Medicinal Chemistry. 45:1959-1962

Potent nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase have been derived from a file compound high throughput screening hit. Optimized compounds show excellent antibacterial activity against staphylococcal and enterococcal pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deacc8f2ad4bccc277d7925dedc661de
https://doi.org/10.1021/jm025502x

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Analogues of SB-203207 as inhibitors of tRNA synthetases

Autor: Weimin Yue, Curtis F. Crasto, Tomislav Karoli, Lucy Mensah, Peter J. O'Hanlon, Martin G. Banwell, Andrew Keith Forrest, Christopher J. Easton, Darren R. March, Mark D Oldham, Michael R. Nairn

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 10:2263-2266

SB-203207 and 10 analogues have been prepared, by elaboration of altemicidin, and evaluated as inhibitors of isoleucyl, leucyl and valyl tRNA synthetases (IRS, LRS, and VRS, respectively). Substituting the isoleucine residue of SB-203207 with leucine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fe42692b2c50e0abba9da248d7f574
https://doi.org/10.1016/s0960-894x(00)00456-x

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Rational Design of Femtomolar Inhibitors of Isoleucyl tRNA Synthetase from a Binding Model for Pseudomonic Acid-A

Autor: Michael L. Doyle, Peter J. O'Hanlon, Lucy Mensah, Andrew Keith Forrest, Christine M. Richardson, Murray J. B. Brown, Andrew J. Pope, Nigel J. P. Broom, Neal Osbourne

Publikováno v: Biochemistry. 39:6003-6011

This paper describes the design and characterization of novel inhibitors of IleRS, whose binding affinity approaches the tightest reported for noncovalent inhibition. Compounds were designed from a binding model for the natural product pseudomonic ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd6ce0b9973957635c392291f7c2812
https://doi.org/10.1021/bi000148v

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Chemistry of Pseudomonic Acid. Part 16. Aryl and Heteroaryl Ketone Derivatives of Monic Acid

Autor: J. M. Wilson, Andrew Keith Forrest, John Stephen Elder, Neil D. Pearson, Philippa A. Coates, Angela Abson, Nicky D. Masson, Peter J. O'Hanlon, Nigel J. P. Broom, Amanda J. Hicks, Peter Charles Thomas Hannan, J. E. Pons

Publikováno v: The Journal of Antibiotics. 49:390-394

The synthesis, antibacterial activities, murine pharmacokinetic and infection model data for a range of aryl and heteroaryl ketone derivatives of monic acid (2a) are reported. The best results were found for the 3-furyl and 2-methoxy thiazol-5-yl ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d863a8b406d31ac36f85500de969a4d
https://doi.org/10.7164/antibiotics.49.390

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The chemistry of pseudomonic acid part 13. Modifications at C-12 to C-14

Autor: Peter J. O'Hanlon, Andrew Keith Forrest, Graham Walker

Publikováno v: Tetrahedron. 50:10739-10748

The novel antibiotic, pseudomonic acid, binds tightly to its target enzyme, isoleucyl t-RNA synthetase. The C12 to C14 region of the molecule is thought to bind to the isoleucine binding site of the enzyme. Semisynthetic analogues in which functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8393914c1729c6f0178492231fdcf5a
https://doi.org/10.1016/s0040-4020(01)89266-8

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