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Autor:
Andrew KL Goey, Mirjam de With, Bram C Agema, Esther Oomen-De Hoop, Rajbir K Singh, Astrid AM van der Veldt, Ron HJ Mathijssen, Ron HN van Schaik, Sander Bins
Publikováno v:
Pharmacogenomics, 20(18), 1283-1290. Future Medicine Ltd.
Aim: The pharmacokinetics and pharmacodynamics of vemurafenib are characterized by a wide interpatient variability. Since multiple polymorphic enzymes and drug transporters are involved in vemurafenib pharmacokinetics, we studied associations of poly