Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Andrew K. Wise"'
Autor:
Elise A. Ajay, Alex C. Thompson, Ajmal A. Azees, Andrew K. Wise, David B. Grayden, James B. Fallon, Rachael T. Richardson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Novel stimulation methods are needed to overcome the limitations of contemporary cochlear implants. Optogenetics is a technique that confers light sensitivity to neurons via the genetic introduction of light-sensitive ion channels. By contro
Externí odkaz:
https://doaj.org/article/7106d198775f496fbdf6ef3d9fe60cd7
Autor:
Jeremy L. Pinyon, Georg vonJonquieres, Edward N. Crawford, Amr Al Abed, John M. Power, Matthias Klugmann, Cherylea J. Browne, David M. Housley, Andrew K. Wise, James B. Fallon, Robert K. Shepherd, John Y. Lin, Catherine McMahon, David McAlpine, Catherine S. Birman, Waikong Lai, Ya Lang Enke, Paul M. Carter, James F. Patrick, Robert D. Gay, Corinne Marie, Daniel Scherman, Nigel H. Lovell, Gary D. Housley
Publikováno v:
Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024)
Abstract Viral vectors and lipofection‐based gene therapies have dispersion‐dependent transduction/transfection profiles that thwart precise targeting. The study describes the development of focused close‐field gene electrotransfer (GET) techno
Externí odkaz:
https://doaj.org/article/1f120ece41dd42df991a8e5de27489c2
Autor:
Jerico V. Matarazzo, Elise A. Ajay, Sophie C. Payne, Ella P. Trang, Alex C. Thompson, Jason B. Marroquin, Andrew K. Wise, James B. Fallon, Rachael T. Richardson
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionElectrical stimulation offers a drug-free alternative for the treatment of many neurological conditions, such as chronic pain. However, it is not easy to selectively activate afferent or efferent fibers of mixed nerves, nor their function
Externí odkaz:
https://doaj.org/article/390b477cfe604745b341045cca1699a7
Autor:
Rachael T. Richardson, Alex C. Thompson, Andrew K. Wise, Elise A. Ajay, Niliksha Gunewardene, Stephen J. O’Leary, Paul R. Stoddart, James B. Fallon
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Optical stimulation is a paradigm-shifting approach to modulating neural activity that has the potential to overcome the issue of current spread that occurs with electrical stimulation by providing focused stimuli. But optical stimulation ei
Externí odkaz:
https://doaj.org/article/07f2283027834332ac810d3131bfc53f
Autor:
Rachael Theresa Richardson, Michael R. Ibbotson, Alexander C. Thompson, Andrew K. Wise, James B. Fallon
Publikováno v:
Healthcare Technology Letters (2020)
Electrical stimulation has been used for decades in devices such as pacemakers, cochlear implants and more recently for deep brain and retinal stimulation and electroceutical treatment of disease. However, current spread from the electrodes limits th
Externí odkaz:
https://doaj.org/article/8aa481fd20454544a3dc449b10ced27c
Autor:
Patrick Lam, Niliksha Gunewardene, Yutian Ma, Frank Caruso, Trung Nguyen, Brianna Flynn, Andrew K. Wise, Rachael T. Richardson
Publikováno v:
MethodsX, Vol 7, Iss , Pp 101078- (2020)
Hearing loss is the most common sensory deficit worldwide with no approved therapeutics for treatment. Local neurotrophin delivery into the cochlea has shown great potential in protecting and repairing the sensory cells important for hearing. However
Externí odkaz:
https://doaj.org/article/67d0740d7550479f92401b6179fd2dd4
Autor:
Niliksha Gunewardene, Patrick Lam, Yutian Ma, Frank Caruso, Sherryl Wagstaff, Rachael T. Richardson, Andrew K. Wise
Publikováno v:
Journal of Controlled Release. 342:295-307
Hearing loss is the most prevalent sensory disorder affecting nearly half a billion people worldwide. Aside from devices to assist hearing, such as hearing aids and cochlear implants, a drug treatment for hearing loss has yet to be developed. The neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e0f7fdae1a1a4c2b1b7e5829a1ceeb
https://doi.org/10.1016/j.jconrel.2021.12.037
https://doi.org/10.1016/j.jconrel.2021.12.037
Auditory nerve responses to combined optogenetic and electrical stimulation in chronically deaf mice
Autor:
Elise A Ajay, Ella P Trang, Alexander C Thompson, Andrew K Wise, David B Grayden, James B Fallon, Rachael T Richardson
Publikováno v:
Journal of Neural Engineering. 20:026035
Objective. Optogenetic stimulation of the auditory nerve offers the ability to overcome the limitations of cochlear implants through spatially precise stimulation, but cannot achieve the temporal precision nor temporal fidelity required for good hear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8f257f9c7ccffb6797caf4d9d864ef5
https://doi.org/10.1088/1741-2552/acc75f
https://doi.org/10.1088/1741-2552/acc75f
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164867 (2016)
Cochlear implants electrically stimulate spiral ganglion neurons (SGNs) in order to provide speech cues to severe-profoundly deaf patients. In normal hearing cochleae the SGNs depend on endogenous neurotrophins secreted by sensory cells in the organ
Externí odkaz:
https://doaj.org/article/df04790a54704996b5df19eaa701c61c
Publikováno v:
Hearing Research. 426:108635
There is an increasing trend to provide cochlear implants for people with useful residual hearing, typically in the low frequency range (2 kHz). These recipients typically use both electrical stimulation from their implant and acoustic stimulation th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83792e8c8210da58571de31e578dfd47
https://doi.org/10.1016/j.heares.2022.108635
https://doi.org/10.1016/j.heares.2022.108635