Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Andrew K. Mlynarchik"'
Autor:
Farwah Iqbal, Florian Schlotter, Dakota Becker-Greene, Adrien Lupieri, Claudia Goettsch, Joshua D Hutcheson, Maximillian A Rogers, Shinsuke Itoh, Arda Halu, Lang Ho Lee, Mark C Blaser, Andrew K Mlynarchik, Sumihiko Hagita, Shiori Kuraoka, Hao Yu Chen, James C Engert, Livia S A Passos, Prabhash K Jha, Eric A Osborn, Farouc A Jaffer, Simon C Body, Simon C Robson, George Thanassoulis, Masanori Aikawa, Sasha A Singh, Abhijeet R Sonawane, Elena Aikawa
Publikováno v:
European Heart Journal. 44:885-898
AimsCalcific aortic valve disease (CAVD) is the most common valve disease, which consists of a chronic interplay of inflammation, fibrosis, and calcification. In this study, sortilin (SORT1) was identified as a novel key player in the pathophysiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17619affe70613293bf816312001402b
https://doi.org/10.1093/eurheartj/ehac818
https://doi.org/10.1093/eurheartj/ehac818
Autor:
Jianguo Wang, Sarvesh Chelvanambi, Andrew K. Mlynarchik, Lang H Lee, Peter Libby, Daniel G. Anderson, C. Keith Ozaki, Sasha A Singh, Shin Mukai, Arda Halu, Amitabh Sharma, Hengmin Zhang, Masanori Aikawa, Julius L. Decano, Joan T. Matamalas, Elena Aikawa, Jiao Qiao, Caue Gasparotto A Bueno
Publikováno v:
Circulation. 143:2454-2470
Background: Vein graft failure remains a common clinical challenge. We applied a systems approach in mouse experiments to discover therapeutic targets for vein graft failure. Methods: Global proteomics and high-dimensional clustering on multiple vein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79ee09e72079c6351db025b37fae9f37
https://doi.org/10.1161/circulationaha.119.043724
https://doi.org/10.1161/circulationaha.119.043724
Autor:
Bernard Delanghe, Andrew K. Mlynarchik, Yoshihiro Yanagihara, Shin Mukai, Sasha A Singh, Abhijeet R. Sonawane, Masanori Aikawa, Hideyuki Higashi, Michael O. Hottiger, Shiori Kuraoka, Mary C. Whelan, Waqas Nasir
Mass-spectrometry-enabled ADP-ribosylation workflows are developing rapidly, providing researchers a variety of ADP-ribosylome enrichment strategies and mass spectrometric acquisition options. Despite the growth spurt in upstream technologies, system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1a7b8a227786cc9a94e4959d8961b3
https://www.zora.uzh.ch/id/eprint/210700/
https://www.zora.uzh.ch/id/eprint/210700/
Autor:
Yusuke Sasaki, Masayuki Ohta, Dhruv Desai, Jose-Luiz Figueiredo, Mary C Whelan, Tomohiro Sugano, Masaki Yamabi, Wataru Yano, Tyler Faits, Katsumi Yabusaki, Hengmin Zhang, Andrew K Mlynarchik, Keisuke Inoue, Ken Mizuno, Masanori Aikawa
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131176 (2015)
Angiopoietin-like protein 2 (ANGPTL2), a recently identified pro-inflammatory cytokine, is mainly secreted from the adipose tissue. This study aimed to explore the role of ANGPTL2 in adipose tissue inflammation and macrophage activation in a mouse mo
Externí odkaz:
https://doaj.org/article/f61753fce6554b6da188e8616ca07920
Autor:
Andrew K. Mlynarchik, Elena Aikawa, Sumihiko Hagita, Maximillian A. Rogers, Masanori Aikawa, Tan Pham, Jennifer R. Wen
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
The sorting receptor Sortilin functions in the regulation of glucose and lipid metabolism. Dysfunctional lipid uptake, storage, and metabolism contribute to several major human diseases including atherosclerosis and obesity. Sortilin associates with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b10203592a29ebf10fb8f9326cce31
http://link.springer.com/article/10.1038/s41598-018-27416-y
http://link.springer.com/article/10.1038/s41598-018-27416-y
Autor:
Andrew K. Mlynarchik, Jose-Luiz Figueiredo, Hengmin Zhang, Ken Mizuno, Anna H. Ha, Arda Halu, Iwao Yamada, Masanori Aikawa, Lang H Lee, Yukiyoshi Yamazaki, Sasha A Singh, Naoaki Arima, Jiao Qiao, Hideyuki Higashi, Yusuke Sasaki
Publikováno v:
Journal of proteome research. 19(1)
Roux-en-Y gastric bypass (RYGB) surgery reduces weight in obese patients. A marked decrease in blood glucose levels occurs before weight loss; however, key molecules that improve the glycemic profile remain largely unknown. Using a murine RYGB surger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e012e1d2171e6c0ff6a3c1d19853da8
https://pubmed.ncbi.nlm.nih.gov/31661273
https://pubmed.ncbi.nlm.nih.gov/31661273
Autor:
Elena Aikawa, Andrew K. Mlynarchik, Sumihiko Hagita, Masanori Aikawa, Jennifer Wen, Maximillian A. Rogers, Tan Pham
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38
Objective: The sorting receptor Sortilin functions in the regulation of glucose and lipid metabolism. Dysfunctional lipid uptake, storage, and metabolism contribute to several major human diseases including atherosclerosis and obesity. Sortilin assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad3663db1650f6881cef545f8130f9fc
https://doi.org/10.1161/atvb.38.suppl_1.595
https://doi.org/10.1161/atvb.38.suppl_1.595
Autor:
Brett Pieper, Michael D. Creager, Maximillian A. Rogers, Mads Kjolby, Jung Choi, Elena Aikawa, Sumihiko Hagita, Tan Pham, Andrew K. Mlynarchik, Claudia Goettsch, Joshua D. Hutcheson, Masanori Aikawa
Publikováno v:
Goettsch, C, Hutscheson, JD, Hagita, S, Rogers, M, Creager, MD, Pham, T, Choi, J, Mlynarchik, AK, Pieper, B, Kjølby, M F, Aikawa, M & Aikawa, E 2016, ' A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification. ', Atherosclerosis, vol. 251 .
Studying atherosclerotic calcification in vivo requires mouse models with genetic modifications. Previous studies showed that injection of recombinant adeno-associated virus vector (AAV) encoding a gain-of-function mutant PCSK9 into mice promotes ath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae518726c8c700361acb7f1396fda23
https://pure.au.dk/portal/da/publications/a-single-injection-of-gainoffunction-mutant-pcsk9-adenoassociated-virus-vector-induces-cardiovascular-calcification-in-mice-with-no-genetic-modification(57d788b0-d47d-4582-830d-044cdc026b68).html
https://pure.au.dk/portal/da/publications/a-single-injection-of-gainoffunction-mutant-pcsk9-adenoassociated-virus-vector-induces-cardiovascular-calcification-in-mice-with-no-genetic-modification(57d788b0-d47d-4582-830d-044cdc026b68).html
Autor:
Maximillian A. Rogers, Elena Aikawa, Jung Choi, Tan Pham, Masanori Aikawa, Michael D. Creager, Claudia Goettsch, Sumihiko Hagita, Andrew K. Mlynarchik, Mads Fuglsang Kjølby, Joshua D. Hutcheson
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 36
Background: Studying atherosclerotic calcification in vivo requires mouse models with genetic deletion of low-density lipoprotein receptor (Ldlr) or apolipoprotein E. A previous study showed a rapid induction of atherosclerosis by proprotein converta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe12965e4eb5f5ed23b08a59160d8dfc
https://doi.org/10.1161/atvb.36.suppl_1.647
https://doi.org/10.1161/atvb.36.suppl_1.647
Autor:
Jung Choi, Joshua D. Hutcheson, Brett Pieper, Elena Aikawa, Claudia Goettsch, Andrew K. Mlynarchik, Tan Pham, Masanori Aikawa
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 36
Background: Clinical evidence links arterial calcification and cardiovascular risk. Fibrous cap microcalcifications can promote atherosclerotic plaque failure, and large calcifications can stabilize the plaque. Therefore, calcification morphology can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f06bae1b6fc75994a584f0fc2c317268
https://doi.org/10.1161/atvb.36.suppl_1.452
https://doi.org/10.1161/atvb.36.suppl_1.452