Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Andrew K. Lindstrom"'
Autor:
Nahid Yazdani, Peter J. Rix, Sergio G. Duron, Celine Bonnefous, Xiaohong Chen, Kent T. Symons, Yan Zhang, Hui Zhang, Li Wang, Stewart A. Noble, Nicholas D. Smith, Christian A. Hassig, Andrew K. Shiau, Natasha Rozenkrants, Tadimeti S. Rao, Andrew K. Lindstrom, Marciano Sablad
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1237-1241
The overproduction of nitric oxide during the biological response to inflammation by the nitric oxide synthase (NOS) enzymes have been implicated in the pathology of many diseases. By removal of the amide core from uHTS-derived quinolone 4, a new ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448d2dd16ce9736e877543f4bd122ddb
https://doi.org/10.1016/j.bmcl.2011.11.073
https://doi.org/10.1016/j.bmcl.2011.11.073
Autor:
Philip J. Skinner, Tawfik Gharbaoui, Vu Hong, Ruoping Chen, Graeme Semple, Huong T. Dang, Martin C. Cherrier, Jeremy G. Richman, Young-Jun Shin, Cameron Pride, Peter J. Webb, Andrew K. Lindstrom, Daniel T. Connolly, Susan Y. Tamura
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5620-5623
A series of 5-alkyl pyrazole-3-carboxylic acids were prepared and found to act as potent and selective agonists of the human GPCR, GPR109a, the high affinity nicotinic acid receptor. No activity was observed at the highly homologous low affinity niac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcab39529ea123f4382bed76ef1b6068
https://doi.org/10.1016/j.bmcl.2007.07.101
https://doi.org/10.1016/j.bmcl.2007.07.101
Autor:
Marc Decaire, Uy Jane, James R. Tata, Jerry Xu, Daniel T. Connolly, P. Douglas Boatman, Philip J. Skinner, Martin C. Cherrier, Nathalie Rodriguez, Peter J. Webb, Jeremy G. Richman, Susan Y. Tamura, Carleton R. Sage, Tracy Duong, Claudia Averbuj, Andrew K. Lindstrom, Benjamin R. Johnson, Ning Zou, Brian M. Smith, Tawfik Gharbaoui, Young-Jun Shin, Ruoping Chen, Thomas O. Schrader, Graeme Semple, Steven L. Colletti, Jae-Kyu Jung
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(17)
A strategy for lead identification of new agonists of GPR109a, starting from known compounds shown to activate the receptor, is described. Early compound triage led to the formulation of a binding hypothesis and eventually to our focus on a series of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddcca5022a855e93279eb0b4fc114125
https://pubmed.ncbi.nlm.nih.gov/17588745
https://pubmed.ncbi.nlm.nih.gov/17588745