Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Andrew K. Evans"'
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Locus coeruleus (LC) noradrenergic (NE) neurons supply the main adrenergic input to the forebrain. NE is a dual modulator of cognition and neuroinflammation. NE neurons of the LC are particularly vulnerable to degeneration both with normal aging and
Externí odkaz:
https://doaj.org/article/9c9a8c39b20f4f6c9d32089f7fa7a1f2
Autor:
Andrew K. Evans, Pooneh M. Ardestani, Bitna Yi, Heui Hye Park, Rachel K. Lam, Mehrdad Shamloo
Publikováno v:
Neurobiology of Disease, Vol 146, Iss , Pp 105089- (2020)
Adrenergic systems regulate both cognitive function and immune function. The primary source of adrenergic signaling in the brain is norepinephrine (NE) neurons of the locus coeruleus (LC), which are vulnerable to age-related degeneration and are one
Externí odkaz:
https://doaj.org/article/aa54e9dbb4614cb9b0f954cfa4a041d1
Autor:
Gaku Ogawa, Mehrdad Shamloo, Ryan D. Leib, Nay Lui Saw, Andrew K. Evans, Kratika Singhal, Heui Hye Park
Publikováno v:
Neurobiol Aging
The locus coeruleus (LC) provides the primary noradrenergic input to the forebrain and hippocampus, and may be vulnerable to degeneration and contribute to age-related cognitive decline and neuroinflammation. Additionally, inhibition of noradrenergic
Autor:
I-Ping Lee, Andrew K Evans, Cissy Yang, Melissa G Works, Vineet Kumar, Zurine De Miguel, Nathan C Manley, Robert M Sapolsky
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109803 (2014)
The obligate intracellular parasite, Toxoplasma gondii, disseminates through its host inside infected immune cells. We hypothesize that parasite nutrient requirements lead to manipulation of migratory properties of the immune cell. We demonstrate tha
Externí odkaz:
https://doaj.org/article/1c2a339f064148bb980fce944795b8c2
Autor:
Pooneh Memar Ardestani, Rachel K. Lam, Mehrdad Shamloo, Bitna Yi, Andrew K. Evans, Heui Hye Park
Publikováno v:
Neurobiology of Disease, Vol 146, Iss, Pp 105089-(2020)
Neurobiol Dis
Neurobiol Dis
Adrenergic systems regulate both cognitive function and immune function. The primary source of adrenergic signaling in the brain is norepinephrine (NE) neurons of the locus coeruleus (LC), which are vulnerable to age-related degeneration and are one
Autor:
Jessica Z. Chan, Jonathan T. Pierce, Pooneh Memar Ardestani, Luisa L. Scott, Stephen F. Martin, Bitna Yi, Sangeetha Iyer, Ashley Crisp, Gabriella Zuniga, Andrew K. Evans, James J. Sahn, Mehrdad Shamloo
Publikováno v:
Journal of Neurochemistry. 140:561-575
Accumulating evidence suggests that modulating the sigma 2 receptor (Sig2R) can provide beneficial effects for neurodegenerative diseases. Herein, we report the identification of a novel class of Sig2R binding ligands and their cellular and in vivo a
Autor:
Vijay S. Pande, Bitna Yi, Mehrdad Shamloo, Michael F. Green, Jacqueline Ernest, Evan N. Feinberg, Andrew K. Evans, Denise I. Briggs, Kristine Ravina, Amir Barati Farimani, Wenchao Sun, Alam Jahangir, Jayakumar Rajadas
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0180319 (2017)
PLoS ONE, Vol 12, Iss 7, p e0180319 (2017)
The beta-1 adrenergic receptor (ADRB1) is a promising therapeutic target intrinsically involved in the cognitive deficits and pathological features associated with Alzheimer's disease (AD). Evidence indicates that ADRB1 plays an important role in reg
Publikováno v:
Brain, Behavior, and Immunity. 37:122-133
Toxoplasma gondii (T. gondii) is one of the world’s most successful brain parasites. T. gondii engages in parasite manipulation of host behavior and infection has been epidemiologically linked to numerous psychiatric disorders. Mechanisms by which
Autor:
Tiffany Nguyen, Pooneh Memar Ardestani, Laurence Coutellier, Bitna Yi, Andrew K. Evans, Mehrdad Shamloo
Publikováno v:
Neuropharmacology. 116
Degeneration of noradrenergic neurons occurs at an early stage of Alzheimer's Disease (AD). The noradrenergic system regulates arousal and learning and memory, and has been implicated in regulating neuroinflammation. Loss of noradrenergic tone may un
Autor:
Linda R. Watkins, Robert R. Rozeske, Steven F. Maier, Matthew G. Frank, Andrew K. Evans, Christopher A. Lowry
Publikováno v:
The Journal of Neuroscience. 31:14107-14115
Uncontrollable stressors produce behavioral changes that do not occur if the organism can exercise behavioral control over the stressor. Previous studies suggest that the behavioral consequences of uncontrollable stress depend on hypersensitivity of