Výsledky vyhledávání - "Andrew K. Coleman"

Calcium and Bicarbonate Signaling Pathways have Pivotal, Resonating Roles in Matching ATP Production to Demand

Autor: Maura Greiser, Mariusz Karbowski, Aaron D. Kaplan, Andrew K. Coleman, Carmen A. Mannella, W. J. Lederer, Liron Boyman

Mitochondrial ATP production in cardiac ventricular myocytes must be continually adjusted to rapidly replenish the ATP consumed by the working heart. Two systems are known to be critical in this regulation: mitochondrial matrix Ca2+([Ca2+]m) and bloo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d016d5312f13fc3f9d2cba9d1bc8dec
https://doi.org/10.1101/2022.10.31.514581

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Quantitative tests reveal that microtubules tune the healthy heart but underlie arrhythmias in pathology

Autor: Christopher W. Ward, Andrew K. Coleman, Humberto C. Joca, George S.B. Williams

Publikováno v: The Journal of physiology

Key points Our group previously discovered and characterized the microtubule mechanotransduction pathway linking diastolic stretch to NADPH oxidase 2-derived reactive oxygen species signals that regulate calcium sparks and calcium influx pathways. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e04b850720ea8e8e93f34015614b26
http://europepmc.org/articles/PMC7432954

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Tubulin acetylation increases cytoskeletal stiffness to regulate mechanotransduction in striated muscle

Autor: Humberto C. Joca, Christopher W. Ward, W. Jonathan Lederer, Andrew K. Coleman, Guoli Shi

Publikováno v: The Journal of General Physiology

Posttranslational modifications in microtubules affect cytoskeletal mechanics and mechanotransduction. In this study, Coleman et al. show that acetylated α-tubulin affects cytoskeletal stiffness and viscoelastic resistance, thus revealing another re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f556b72641ad488359049802911f2427
http://europepmc.org/articles/PMC7988512

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Deletion of obscurin immunoglobulin domains Ig58/59 leads to age-dependent cardiac remodeling and arrhythmia

Autor: Christopher W. Ward, Humberto C. Joca, Alyssa Grogan, Aikaterini Kontrogianni-Konstantopoulos, Andrew K. Coleman, Mark W. Russel, Henk Granzier

Publikováno v: Basic Res Cardiol

Obscurin comprises a family of giant modular proteins that play key structural and regulatory roles in striated muscles. Immunoglobulin domains 58/59 (Ig58/59) of obscurin mediate binding to essential modulators of muscle structure and function, incl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a086da81e3cd227b51c8d47098eca2
https://doi.org/10.1007/s00395-020-00818-8

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Dynamics of the Mitochondrial Permeability Transition Pore: Transient and Permanent Opening Events

Autor: Christopher W. Ward, Andrew K. Coleman, Andrew P. Wescott, Guiling Zhao, B. Maura Greiser, W. J. Lederer, Mariusz Karbowski, Liron Boyman, Humberto C. Joca

Publikováno v: Arch Biochem Biophys

A gentle optical examination of the mitochondrial permeability transition pore (mPTP) opening events was carried out in isolated quiescent ventricular myocytes by tracking the inner membrane potential (ΔΨ(M)) using TMRM (tetramethylrhodamine methyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db7fc6183b563c541967e9bf7f25698
https://europepmc.org/articles/PMC6538282/

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