Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Andrew K L, Goey"'
Publikováno v:
Therapeutic Drug Monitoring. 45:327-336
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb2ff5f059a0fe0cf31d7a9ad94a876d
https://doi.org/10.1097/ftd.0000000000001063
https://doi.org/10.1097/ftd.0000000000001063
Autor:
Doreen Z. Mhandire, Andrew K. L. Goey
Publikováno v:
Mol Diagn Ther
Many anticancer drugs cause adverse drug reactions (ADRs) that negatively impact safety and reduce quality of life. The typical narrow therapeutic range and exposure-response relationships described for anticancer drugs make precision dosing critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20a0f236cbd9ae631e7efe9d20cb368
https://doi.org/10.1007/s40291-021-00575-x
https://doi.org/10.1007/s40291-021-00575-x
Autor:
Emily M. Harris, Jonathan D. Strope, Shaunna L. Beedie, Phoebe A. Huang, Andrew K. L. Goey, Kristina M. Cook, Christopher J. Schofield, Cindy H. Chau, Melissa M. Cadelis, Brent R. Copp, Kirk R. Gustafson, William D. Figg
Publikováno v:
Marine Drugs, Vol 16, Iss 7, p 241 (2018)
Elements of the hypoxia inducible factor (HIF) transcriptional system, a key regulator of the cellular hypoxic response, are up-regulated in a range of cancer cells. HIF is fundamentally involved in tumor angiogenesis, invasion, and energy metabolism
Externí odkaz:
https://doaj.org/article/d95ebade53c845c4a7d6092fce254125
Publikováno v:
Clinical Pharmacokinetics
Clinical Pharmacokinetics, 57(10), 1229-1254. Adis
Clinical Pharmacokinetics, 57(10), 1229-1254. Adis
Since its clinical introduction in 1998, the topoisomerase I inhibitor irinotecan has been widely used in the treatment of solid tumors, including colorectal, pancreatic, and lung cancer. Irinotecan therapy is characterized by several dose-limiting t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b02aeded2409546756d53c242b8c76
https://doi.org/10.1007/s40262-018-0644-7
https://doi.org/10.1007/s40262-018-0644-7
Autor:
Jung-Min Lee, Andrew K. L. Goey, Lori M. Minasian, Victoria L. Chiou, Bernard Parker, Nicolas Gordon, Cody J. Peer, Robert F. Murphy, Nicole D. Houston, Tristan M. Sissung, William D. Figg, Minshu Yu, Lauren Amable, Elise C. Kohn, Christina M. Annunziata, Brigitte C. Widemann
Publikováno v:
Clinical Cancer Research. 23:1397-1406
Purpose: Our preclinical studies showed that the PARP inhibitor, olaparib, prior to carboplatin attenuated carboplatin cytotoxicity. We evaluated sequence-specific pharmacokinetic and pharmacodynamic effects, safety, and activity of the combination.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e011272634c437c2b00bf1d605f66d
https://doi.org/10.1158/1078-0432.ccr-16-1546
https://doi.org/10.1158/1078-0432.ccr-16-1546
Autor:
Andrew K. L. Goey, Leo A. Joyce, Arvin Moser, Tawnya C. McKee, James B. McMahon, Kirk R. Gustafson, Josep Saurí, Scott A. MacDonald, Shabana I. Khan, Wes Schafer, R. Thomas Williamson, Roger R. Nani, Tanya T. Ransom, William D. Figg, Susanna T. S. Chan, Evan A. Schauer, Gary E. Martin, Alexei V. Buevich, Martin J. Schnermann, Curtis J. Henrich
Publikováno v:
The Journal of Organic Chemistry. 81:10631-10640
An extract of Eudistoma sp. provided eudistidine C (1), a heterocyclic alkaloid with a novel molecular framework. Eudistidine C (1) is a racemic natural product composed of a tetracyclic core structure further elaborated with a p-methoxyphenyl group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b5c6e21d8cfe3f10d851479c58413e
https://doi.org/10.1021/acs.joc.6b02380
https://doi.org/10.1021/acs.joc.6b02380
Publikováno v:
Pharmacogenomics. 17:1807-1815
The histone deacetylase inhibitor valproic acid (VPA) has been used for many decades in neurology and psychiatry. The more recent introduction of the histone deacetylase inhibitors (HDIs) belinostat, romidepsin and vorinostat for treatment of hematol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e992332936ddea415c5feeb8957b8c6
https://doi.org/10.2217/pgs-2016-0113
https://doi.org/10.2217/pgs-2016-0113
Autor:
Andrew K. L. Goey, William D. Figg
Publikováno v:
Pharmacological Research. 105:22-27
Certain genetic polymorphisms of UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) can reduce gene expression (*28, *60, *93) or activity (*6), thereby altering the pharmacokinetics, pharmacodynamics, and the risk of toxicities of UGT1A1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b708c368b5f30d91f4284e083624db21
https://doi.org/10.1016/j.phrs.2016.01.002
https://doi.org/10.1016/j.phrs.2016.01.002
Autor:
William D. Figg, Sheryl Erlich, Richard Piekarz, Min-Jung Lee, Andrew K. L. Goey, Jane B. Trepel, Yusuke Tomita, Cody J. Peer, Susan E. Bates, Tristan M. Sissung, Sanjeeve Balasubramaniam
Publikováno v:
The Journal of Clinical Pharmacology. 56:450-460
Belinostat is a second-generation zinc-binding histone deacetylase inhibitor that is approved for peripheral T-cell lymphoma and is currently being studied in small cell lung cancer and other advanced carcinomas as a 48-hour continuous intravenous in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228613f985591ec24dd603aa0a30812c
https://doi.org/10.1002/jcph.627
https://doi.org/10.1002/jcph.627
Autor:
Tanya R. Ransom, James B. McMahon, Melissa M. Cadelis, Kristina M. Cook, William D. Figg, Amaya Castro, Andrew K. L. Goey, Brent R. Copp, Tristan M. Sissung, Cindy H. Chau, Curtis J. Henrich, Tanja Grkovic, Kirk R. Gustafson, Tawnya C. McKee, David Venzon
Inhibition of the hypoxia-inducible factor 1α (HIF-1α) pathway by disrupting its association with the transcriptional coactivator p300 inhibits angiogenesis and tumor development. Development of HIF-1α/p300 inhibitors has been hampered by preclini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c34c7fe3a2bf3a4f265826b1fc22e41
https://europepmc.org/articles/PMC6323635/
https://europepmc.org/articles/PMC6323635/
