Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Andrew K Groves"'
Autor:
Daniel C Sutton, Jonathan C Andrews, Dylan M Dolezal, Ye Jin Park, Hongjie Li, Daniel F Eberl, Shinya Yamamoto, Andrew K Groves
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0297846 (2024)
Johnston's organ, the Drosophila auditory organ, is anatomically very different from the mammalian organ of Corti. However, recent evidence indicates significant cellular and molecular similarities exist between vertebrate and invertebrate hearing, s
Externí odkaz:
https://doaj.org/article/fba94050aa174f179ac9f784f3615d64
Autor:
Amrita A Iyer, Ishwar Hosamani, John D Nguyen, Tiantian Cai, Sunita Singh, Melissa M McGovern, Lisa Beyer, Hongyuan Zhang, Hsin-I Jen, Rizwan Yousaf, Onur Birol, Jenny J Sun, Russell S Ray, Yehoash Raphael, Neil Segil, Andrew K Groves
Publikováno v:
eLife, Vol 11 (2022)
Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1 has been proposed as a potential therapeutic strategy for hearing loss. ATOH1 expression in the developing cochlea can efficiently induce hair cell regeneration
Externí odkaz:
https://doaj.org/article/4cbcd933e07d46508ec37fe3ede0949c
Autor:
Hsin-I Jen, Matthew C Hill, Litao Tao, Kuanwei Sheng, Wenjian Cao, Hongyuan Zhang, Haoze V Yu, Juan Llamas, Chenghang Zong, James F Martin, Neil Segil, Andrew K Groves
Publikováno v:
eLife, Vol 8 (2019)
The mammalian cochlea loses its ability to regenerate new hair cells prior to the onset of hearing. In contrast, the adult vestibular system can produce new hair cells in response to damage, or by reprogramming of supporting cells with the hair cell
Externí odkaz:
https://doaj.org/article/627c72e39e6e4cba80400a301229c433
Autor:
Fatih Semerci, William Tin-Shing Choi, Aleksandar Bajic, Aarohi Thakkar, Juan Manuel Encinas, Frederic Depreux, Neil Segil, Andrew K Groves, Mirjana Maletic-Savatic
Publikováno v:
eLife, Vol 6 (2017)
Hippocampal neural stem cells (NSCs) integrate inputs from multiple sources to balance quiescence and activation. Notch signaling plays a key role during this process. Here, we report that Lunatic fringe (Lfng), a key modifier of the Notch receptor,
Externí odkaz:
https://doaj.org/article/37cf9c79636245ebb92a61c96e350631
Autor:
Martin L Basch, Rogers M Brown II, Hsin-I Jen, Fatih Semerci, Frederic Depreux, Renée K Edlund, Hongyuan Zhang, Christine R Norton, Thomas Gridley, Susan E Cole, Angelika Doetzlhofer, Mirjana Maletic-Savatic, Neil Segil, Andrew K Groves
Publikováno v:
eLife, Vol 5 (2016)
The signals that induce the organ of Corti and define its boundaries in the cochlea are poorly understood. We show that two Notch modifiers, Lfng and Mfng, are transiently expressed precisely at the neural boundary of the organ of Corti. Cre-Lox fate
Externí odkaz:
https://doaj.org/article/ef349eec4d0042e7ac246fa6ab85e782
Autor:
Tongchao Li, Nikolaos Giagtzoglou, Daniel F Eberl, Sonal Nagarkar Jaiswal, Tiantian Cai, Dorothea Godt, Andrew K Groves, Hugo J Bellen
Publikováno v:
eLife, Vol 5 (2016)
Myosins play essential roles in the development and function of auditory organs and multiple myosin genes are associated with hereditary forms of deafness. Using a forward genetic screen in Drosophila, we identified an E3 ligase, Ubr3, as an essentia
Externí odkaz:
https://doaj.org/article/395fa650cd994601891d59c455ddf682
Autor:
Tongchao Li, Junkai Fan, Bernardo Blanco-Sánchez, Nikolaos Giagtzoglou, Guang Lin, Shinya Yamamoto, Manish Jaiswal, Kuchuan Chen, Jie Zhang, Wei Wei, Michael T Lewis, Andrew K Groves, Monte Westerfield, Jianhang Jia, Hugo J Bellen
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006054 (2016)
Hedgehog (Hh) signaling regulates multiple aspects of metazoan development and tissue homeostasis, and is constitutively active in numerous cancers. We identified Ubr3, an E3 ubiquitin ligase, as a novel, positive regulator of Hh signaling in Drosoph
Externí odkaz:
https://doaj.org/article/4980a293e69a4e169d42d8dce10c8eec
Autor:
Juan C Maass, Rende Gu, Tiantian Cai, Ying-Wooi Wan, Silvia C Cantellano, Joanna S T Asprer, Hongyuan Zhang, Hsin-I Jen, Renée K Edlund, Zhandong Liu, Andrew K Groves
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167286 (2016)
Neonatal mouse cochlear supporting cells have a limited ability to divide and trans-differentiate into hair cells, but this ability declines rapidly in the two weeks after birth. This decline is concomitant with the morphological and functional matur
Externí odkaz:
https://doaj.org/article/ba681abddecc40ff923e417a0fa3bc6f
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005037 (2015)
Neurons of the statoacoustic ganglion (SAG) transmit auditory and vestibular information from the inner ear to the hindbrain. SAG neuroblasts originate in the floor of the otic vesicle. New neuroblasts soon delaminate and migrate towards the hindbrai
Externí odkaz:
https://doaj.org/article/694cd4a75bce4ff7bcb9255c67adf07c
Autor:
Yalda Moayedi, Martin L Basch, Natasha L Pacheco, Simon S Gao, Rosalie Wang, Wilbur Harrison, Ningna Xiao, John S Oghalai, Paul A Overbeek, Graeme Mardon, Andrew K Groves
Publikováno v:
PLoS Genetics, Vol 10, Iss 1, p e1004055 (2014)
The Notch signaling pathway is thought to regulate multiple stages of inner ear development. Mutations in the Notch signaling pathway cause disruptions in the number and arrangement of hair cells and supporting cells in sensory regions of the ear. In
Externí odkaz:
https://doaj.org/article/2280be277ac146019ba8888a9e473d2a