Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Andrew K, Urick"'
Autor:
Alex Dickson, Hideki Aihara, Mohammed Kashani-Sabet, Junwei Shi, Jorden A. Johnson, Steven E. Kirberger, Ke Shi, Michael F. Ciccone, Peter D. Ycas, Andrew K. Urick, William C. K. Pomerantz, Rinette Woo, Camila O. dos Santos, Sean D. McAllister, Huda Zahid, Chen Chen
Publikováno v:
Organicbiomolecular chemistry. 17(7)
Bromodomain and PHD finger containing protein transcription factor (BPTF) is an epigenetic protein involved in chromatin remodelling and is a potential anticancer target. The BPTF bromodomain has one reported small molecule inhibitor (AU1, rac-1). He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c15fc8e76d4e955d7c055f91cdea57a
https://pubmed.ncbi.nlm.nih.gov/30706071
https://pubmed.ncbi.nlm.nih.gov/30706071
Publikováno v:
ACS Chem Biol
To evaluate its potential as a ligand discovery tool, we compare a newly developed 1D protein-observed fluorine NMR (PrOF NMR) screening method with the well-characterized ligand-observed (1)H CPMG NMR screen. We selected the first bromodomain of Brd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa11549cb0bbc6583fec694cb78a2a4e
https://doi.org/10.1021/acschembio.6b00730
https://doi.org/10.1021/acschembio.6b00730
Publikováno v:
Tetrahedron. 72:6052-6063
Exocyclic allene natural products and pharmaceutical agents are rare but interesting compounds: Fucoxanthin, grasshopper ketone, and analogues of prostacyclins, cephalosporins, antithrombic agents and sterol biosynthesis inhibitors are representative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fe3d59fc34a77f2da41828e362bd406
https://doi.org/10.1016/j.tet.2016.07.058
https://doi.org/10.1016/j.tet.2016.07.058
Protein-observed 19F-NMR for fragment screening, affinity quantification and druggability assessment
Autor:
Andrew K. Urick, Andrea J. Wisniewski, Neeraj K. Mishra, Laura M. L. Hawk, William C. K. Pomerantz, Keith E. Arntson, Clifford T. Gee
Publikováno v:
Nat Protoc
Labeling of proteins with fluorinated amino acids and using fluorine-19 NMR greatly simplifies the NMR spectrum. Changes in the spectrum on interaction with ligands makes protein-observed fragment-based drug screening possible. NMR spectroscopy can b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8b700b3e25a185ecdf0586a2193e07
https://doi.org/10.1038/nprot.2016.079
https://doi.org/10.1038/nprot.2016.079
Publikováno v:
RSC Advances. 6:95715-95721
Protein-observed 19F (PrOF) NMR is an emerging tool for ligand discovery. To optimize the efficiency of PrOF NMR experiments, paramagnetic relaxation enhancement through the addition of chelated Ni(II) was used to shorten longitudinal relaxation time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1cb3a2035c41c5ad295de39d7e143c6
https://doi.org/10.1039/c6ra21226c
https://doi.org/10.1039/c6ra21226c
Autor:
Laura M. L. Hawk, Melissa K. Cassel, Wei Zhang, Neeta Adhikari, Jennifer L. Hall, Shuai Liu, Andrew K. Urick, William C. K. Pomerantz, Neeraj K. Mishra, Camila O. dos Santos
Publikováno v:
ACS Chemical Biology. 10:2246-2256
Bromodomain-containing protein dysregulation is linked to cancer, diabetes, and inflammation. Selective inhibition of bromodomain function is a newly proposed therapeutic strategy. We describe a (19)F NMR dual screening method for small molecule disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a375d9035043fd5594ac1e633d94274b
https://doi.org/10.1021/acschembio.5b00483
https://doi.org/10.1021/acschembio.5b00483
Publikováno v:
RSC advances. 6(98)
Protein-observed 19F (PrOF) NMR is an emerging tool for ligand discovery. To optimize the efficiency of PrOF NMR experiments, paramagnetic relaxation enhancement through the addition of chelated Ni(II) was used to shorten longitudinal relaxation time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e3146d7cb2834936b2dcda4a7772966c
https://pubmed.ncbi.nlm.nih.gov/28496971
https://pubmed.ncbi.nlm.nih.gov/28496971
Publikováno v:
ACS Chemical Biology
We describe a 19F NMR method for detecting bromodomain–ligand interactions using fluorine-labeled aromatic amino acids due to the conservation of aromatic residues in the bromodomain binding site. We test the sensitivity, accuracy, and speed of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9c9c27cb9e2758801a9265b3c2a564
http://europepmc.org/articles/PMC4273984
http://europepmc.org/articles/PMC4273984
Publikováno v:
ACS Chemical Biology
This correction regards a typographical error found in Figure Figure33B of the recent letter in the December issue of ACS Chemical Biology (ACS Chem. Biol., 2014, 9, 2755–2760) by Pomerantz and co-workers. In this report, the authors use chemica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60fc8b16071164ce2fc4f8006601cf45
https://doi.org/10.1021/acschembio.6b00049
https://doi.org/10.1021/acschembio.6b00049