Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Andrew Jonathan Harris"'
Autor:
James N.C. Kew, Peter R. Maycox, Ellen M. Soffin, Rosemary A. Melarange, Andrew Jonathan Harris, Melanie J. Robbins, Claire Rourke, Jay Strum, Fiona M. Kelly, Magalie Rocheville, Gareth A. Jones, Declan N.C. Jones, Paul R. Murdock, Tom Rupniak, Andy Honey, Kathryn R. Starr
Publikováno v:
Brain Research. 1152:215-227
Aberrant glutamatergic neurotransmission may underlie the pathogenesis of schizophrenia and metabotropic glutamate receptors (mGluRs) have been implicated in the disease. We have established the localization of the group III mGluR subtype, mGluR8, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1281b827d16319258572c1d22e0e1b25
https://doi.org/10.1016/j.brainres.2007.03.028
https://doi.org/10.1016/j.brainres.2007.03.028
Autor:
Elisa Ballini, Benjamin D. Bax, Beatrice Oliosi, Claudette Mookherjee, Daniel Marcus Bradley, Stuart P. Ballantine, Nigel E. Austin, Kevin M. Thewlis, Rosemary A. Melarange, Shahnaz P. Yusaf, Gianni Dal Negro, Andrew Jonathan Harris, J. Mosley, Kathrine J. Smith, Laura Aldegheri, Simon E. Ward, B. Clarke, Stephen A Harrison, Mark H Harries, Patrick M. Woollard
Publikováno v:
Journal of medicinal chemistry. 54(1)
A novel series of AMPAR positive modulators is described that were identified by high throughput screening. The molecules of the series have been optimized from a high quality starting point hit to afford excellent developability, tolerability, and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f968ae85bfba5e74967880d1ee4d863
https://pubmed.ncbi.nlm.nih.gov/21128618
https://pubmed.ncbi.nlm.nih.gov/21128618
Autor:
Kathrine J. Smith, Roberto Profeta, Simon E. Ward, Marta Neve, Simone Spada, Beatrice Oliosi, Jesper Lund, Andrew Jonathan Harris, Anna Mingardi, Claudette Mookherjee, Stuart P. Ballantine, Rosemary A. Melarange, Laura Aldegheri, Andy J. Harker, Benjamin D. Bax, Mark H Harries, Kevin M. Thewlis, Paul W. Smith, Daniele Andreotti, J. Mosley, Shahnaz P. Yusaf
Publikováno v:
Journal of medicinal chemistry. 53(15)
A series of AMPA receptor positive allosteric modulators has been optimized from poorly penetrant leads to identify molecules with excellent preclinical pharmacokinetics and CNS penetration. These discoveries led to 17i, a potent, efficacious CNS pen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154b627b7254de36c15c9e847ad6636c
https://pubmed.ncbi.nlm.nih.gov/20614889
https://pubmed.ncbi.nlm.nih.gov/20614889